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Pentacle IC
Last reviewed: 03.07.2025
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Five-fingered rhododendron IC has good analgesic, anti-inflammatory and antipyretic effects, i.e. it is a combined drug. The medicine is mainly used for pain of various origins. Five-fingered rhododendron IC is especially effective for pain in muscles, joints, radiculitis, damage to peripheral nerves, menstrual pain. Five-fingered rhododendron IC also helps to cope with headaches, toothaches and migraines.
The medicine is often prescribed for colds and feverish conditions, as it effectively relieves inflammation in the body.
Five-fir-tailed cinquefoil IC is a fairly popular drug that is widely used for various pain syndromes, in addition, the drug has a pronounced antipyretic and anti-inflammatory effect, it helps well to cope with a feverish state and high temperature during colds. However, such a remedy is not recommended to be used uncontrollably and in large quantities, since this can provoke a number of undesirable side effects, as well as cause addiction.
Indications Pentacle IC
Five-Fold IC is prescribed for severe pain of various types: muscle and joint pain, inflammation of the nerve roots in the intervertebral foramina (radiculitis), severe pain during menstruation, diseases of the peripheral nerves (neuralgia), migraines, toothaches or headaches. Five-Fold IC is also often used for colds, when the patient's condition is aggravated by fever, pain, and some inflammatory processes.
Release form
The medicine is available in the form of white or yellowish tablets. The tablets are flat-cylindrical, with a dividing strip. The trademark of the company that produces Pyatirchatka IC may be printed on one side.
Pharmacodynamics
When taken, Pentacle IC has a combined effect: it reduces temperature, relieves pain, and eliminates inflammatory processes.
Analgin (metamizole sodium), which is part of Pyatyrchatka IC, relieves pain and reduces fever, relaxes the smooth muscles of the urinary tract, biliary tract, and uterus. The therapeutic effect can be observed after 20-40 minutes, the maximum effect of Pyatyrchatka IC appears after two hours. Paracetamol has a slight analgesic effect and relieves fever well. Caffeine has a stimulating effect on some centers of the medulla oblongata, promotes the penetration of analgesics through the blood-brain barrier, prevents collapse, and reduces the sedative effect of other components of Pyatyrchatka IC.
Phenobarbital has a calming effect, relieves spasms, activates the action of analgesics included in the drug, and has a muscle relaxant effect (reduces muscle tone).
Codeine is a narcotic analgesic, reduces the excitability of the cough center, relieves pain. Pentacle IC in small doses does not depress the respiratory center, does not reduce bronchial secretion and does not disrupt the work of the ciliated epithelium. It enhances the effect of sedatives, sleeping pills and painkillers. With frequent unjustified use of drugs that include codeine, there is a disruption of the gastrointestinal tract.
Pharmacokinetics
Analgin is absorbed in the gastrointestinal tract, breakdown occurs in the intestine with the formation of an active metabolite, which binds to blood cells by 50-60%, followed by breakdown in the liver, and is finally excreted by the kidneys.
Also, Paracetamol is quickly absorbed in the gastrointestinal tract, then the component binds to blood cells. In the liver, it is broken down to form glucuronide and paracetamol sulfate. It is mainly excreted by the kidneys.
Caffeine is absorbed in the intestines, then the component is broken down in the liver and excreted from the body through the kidneys.
Phenobarbital is absorbed in the same way as other components in the gastrointestinal tract, but rather slowly. It is broken down in the liver. The half-life from the body is 3-4 days. It is excreted by the kidneys (25-50% unchanged), the substance easily overcomes the placental barrier.
Codeine, due to its similarity to fats, easily crosses the blood-brain barrier, accumulates mainly in adipose tissue, a small amount can be observed in some internal organs (lungs, spleen, kidneys, liver). It is mainly excreted through the kidneys in the form of metabolites, a small amount of the substance is excreted with bile.
Renal failure may result in accumulation of active metabolites, which will affect the duration of action of codeine in the body.
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Dosing and administration
Pentagram IC is taken orally. Adults and children over 12 years of age should take one tablet 1-2 times a day. No more than two tablets should be taken at a time, and no more than six tablets should be taken per day.
The duration of treatment is five days. The recommended treatment period can be extended only by appointment of a specialist and under his strict supervision.
Use Pentacle IC during pregnancy
Pentaerythritol IC is not recommended during pregnancy or breastfeeding. Due to the phenobarbital included in the composition, it is not recommended for pregnant women to take Pentaerythritol IC, since it easily penetrates the placenta and can disrupt blood clotting in a newborn baby, in addition, Pentaerythritol IC can provoke postpartum hemorrhage.
Contraindications
Five-fingered IC is contraindicated in case of hypersensitivity to any component included in the drug. The drug should not be taken with increased intraocular pressure, intracranial hypertension, liver or kidney dysfunction, bronchospasms, various blood disorders (anemia, leukopenia, etc.), glucose-6-phosphate dehydrogenase deficiency, peptic ulcer, children under 12 years of age, women during pregnancy or breastfeeding.
Side effects Pentacle IC
Usually occurring side effects after taking Pyatirchatka IC have a short-term effect and after stopping the intake they disappear on their own. In patients with a strong susceptibility to certain components of the drug, the likelihood of developing anaphylactic shock increases, which can occur regardless of the daily dose.
Pentacle IC may cause itching, skin rash, bronchospasm, dyspnea, Quincke's edema, severe erythema (vesicles on the oral mucosa). From the digestive system, nausea, vomiting, increased activity of liver enzymes, dry mouth, constipation (or diarrhea), complete or partial loss of appetite may occur.
Taking the drug may cause a malfunction of the nervous system: trembling of the limbs, increased irritability and rapid fatigue, impaired coordination, sleep, anxiety.
Taking the drug can cause a decrease in blood pressure, increased heart rate, and in some cases, anemia in various forms can develop.
Long-term and uncontrolled use of the drug in large doses can lead to addiction.
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Overdose
In case of overdose, Pentacle IC provokes nausea, vomiting, increased heart rate, depression, various allergic reactions, decreased pulse, and a feeling of weakness. In case of overdose, it is recommended to induce vomiting and take activated charcoal, as well as symptomatic treatment.
Interactions with other drugs
Pentacle IC when taken together with non-narcotic painkillers can provoke more pronounced toxic effects. Paracetamol can reduce the effect of drugs that are broken down in the liver. Rifampicin reduces the analgesic effect of paracetamol, cimetidine reduces the toxic effect and increases the analgesic effect.
Classical antidepressants, oral contraceptives, allopurinol increase the toxic effects of analgin, inducers of microsomal liver enzymes reduce the therapeutic effect of the drug. When taking analgin and cyclosporine, a significant decrease in the level of the latter in the blood is observed.
Sleeping pills, sedatives, barbiturates, benzodiazepines, alcohol act more actively when taken simultaneously with codeine (one of the components of the IC Five-Tyrant). Also, the simultaneous use of codeine and antidepressants and monoamine oxidase inhibitors can mutually increase the therapeutic effect of the components.
Caffeine reduces the effect of sleeping pills. Phenobarbital increases the rate of chemical reactions in the body of such substances as carbamazepine, estrogen, phenytoin, doxycycline, griseofulvin, quinidine. The depressant effect of phenobarbital is enhanced by taking alcohol, classic antidepressants, narcotic analgesics, phenothiazine.
Sedatives and tranquilizers enhance the analgesic effect of Pentaerythrocyte IC. When taken with alcohol, the likelihood of liver dysfunction increases, since the toxic effect on the organ increases. The chemical reaction in the body of phenobarbital will decrease with the parallel use of sodium valproate and valproic acid.
Storage conditions
The medicine must be stored in a place well protected from light and moisture, the optimal storage temperature is from 15 to 25 0 C. Pentaerythritol IC should be kept out of the reach of children.
Shelf life
Shelf life is three years from the date of manufacture. It is not recommended to use after the expiration date.
Attention!
To simplify the perception of information, this instruction for use of the drug "Pentacle IC" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.