Potassium orotate

A medicinal product belonging to the group of anabolics - potassium orotate - is produced by ZAO NPC Borshchagovsky Chemical and Pharmaceutical Plant, as well as at many other pharmaceutical plants.

[1], [2], [3], [4], [5], [6]

Indications Potassium orotate

In accordance with the instructions, the indication for the use of the drug is:

1. Myocardial infarction.
2. Anemia.
3. Heart failure, in chronic form (stages II and III).
4. Bacterial or drug intoxication.
5. Atrial fibrillation.
6. Progression of muscular dystrophy.
7. Toxic lesion of the liver and bile ducts (except ascitic syndrome with cirrhosis of the liver).
8. Dystrophic changes in the myocardium.
9. Exxtrosystole.
10. Dermatosis.
11. Dystrophy in children of alimentary and infectious-alimentary genesis.
12. The period of convalescence after infectious diseases, with high physical loads.
13. Therapy of edema during pregnancy, the normalization of the potassium balance.

[7]

Release form

Tablets are round-shaped, cylindrical, bounded by two planes with truncated edges. One of their planes has a dividing risk.
Packing - 10 pieces in one blister. Packing from cardboard can have 1, 2, 3 or 6 blisters.
The preparation is produced in quantities of 20 - 30 pieces and in vials of polymer.
The active active substance of the drug is potassium orotate, the concentration in one tablet is 500 mg.
Additional substances: stearic acid, potato starch, medical gelatin and lactose.

[8]

Pharmacodynamics

Orthoic acid is a drug with an anabolic, non-steroidal effect.
The drug normalizes the metabolism of lipids and proteins, being a precursor of ribonucleotides of thymine, uracil and cytosine. His involvement in carbohydrate metabolism is due to the effect on galactose metabolism. Activates the synthesis of nucleic acids.
Potassium orotate has a regenerating and reparative effect. Has a diuretic effect.
Potassium orotate promotes better tolerability of cardiac glycosides and activates the synthesis of albumin in the liver.

 

[9], [10], [11]

Pharmacokinetics

The level of absorption of the preparation of the mucosa of the digestive tract is rather low and amounts to no more than a tenth of the total volume of the drug taken.
In the liver, the drug is metabolized into one of its metabolites, orotidin-5-phosphate.
The organism displays Kalia orotate through the kidneys together with the urine.

[12], [13], [14], [15],

Dosing and administration

The drug is recommended to be used orally one hour before meals or four hours after eating. Dosage - 250 to 500 mg twice - three times a day. Duration of treatment is from 20 to 40 days.
If necessary, the daily intake of potassium orotate can be increased to 3 g, which corresponds to 6 tablets.
If therapeutic efficacy is not achieved and re-treatment is required, it can be started no earlier than one month after the end of the first course.
Children daily dose of the drug is calculated by the formula: 10 - 20 mg per kilogram of the child's weight. The received quantity is divided into 2 - 3 admission.
It is recommended to take 1 tablet twice - three times a day. It is necessary to monitor the volume of the kidney fluid.
Cardiac patients are advised to administer potassium orotate against magnesium intake. Potassium orotate is not prescribed as a potassium-containing drug for potassium replacement therapy.

[18], [19], [20]

Use Potassium orotate during pregnancy

The drug can be used during pregnancy. It is prescribed to the pregnant woman as a remedy replenishing the deficit of potassium in the body.

Contraindications

There are also contraindications to the use of Potassium orotate:

1. High physical activity.
2. Ascites in liver cirrhosis.
3. Nephrourolithiasis.
4. Renal dysfunction in the chronic stage.
5. Individual intolerance of the component composition of the drug, including orotic acid.

Side effects Potassium orotate

The drug is well tolerated by the body, but potassium orotate can still cause various side effects:

1. Allergic dermatosis: rash, peeling, flushing, itching, burning and swelling.
2. Dyspepsia.

These symptoms are short-lived and after the drug is withdrawn independently.

[16], [17]

Overdose

No data on drug overdose. Potassium orotate not registered.

[21], [22], [23], [24], [25]

Interactions with other drugs

With the joint intake of potassium orotate and preparations of the tetracycline group, the level of absorption of the latter worsens.
The toxicity of cardiac glycosides decreases. But the mutual influence of potassium orotate and folic acid, magnesium or cyanocobalamin preparations increase the effectiveness of both.
At simultaneous reception with oral contraceptives, preparations of the group of glucocorticosteroids, with insulin, diuretics or muscle relaxants, the pharmacological characteristics of Potassium orotate deteriorate.
Preparations of sodium fluoride and iron are less absorbed by the mucous membrane of the gastrointestinal tract when combined with potassium orotate.

[26], [27]

Storage conditions

The storage conditions for the preparation of potassium orotate consist of a number of items:

1. The medicine should be kept in a dry place and protected from direct sunlight.
2. The temperature in the room should not exceed + 25 degrees above zero.
3. Keep the medicine in places that are not available for adolescents and young children.

[28], [29]

Shelf life

Shelf life of anabolic potassium iodide is four years (48 months).

[30], [31],