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Nadoxin
Last reviewed: 23.04.2024
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Nadoxin refers to topical medications. The code is based on the ATC classifier D10AF.
[1]
Indications Nadoxin
Nadoxin is intended for external treatment of such diseases:
- infectious-inflammatory dermatological pathologies;
- acne eruptions;
- inflammation of the follicles (including the superficial form of the disease - sycosis);
- furuncles;
- otitis media.
Also, the drug can be prescribed as an additional symptomatic treatment for gonorrheal prostatitis.
In dermatological practice, Nadoxin is used to treat many infectious skin diseases that are caused by bacteria that are sensitive to the drug.
Release form
Nadoxin is a cream for applying to the surface of the skin. The product has a uniform consistency and a light, almost white, color. The cream is placed in a tube and cardboard package, 10 grams each in one tube.
In 1 g of the drug contains active ingredient Nadifloxacin 10 mg.
Auxiliary ingredients are represented by vaseline oil, alcohol (cetostearyl), alpha-tocopherol, propylene glycol, etc.
Pharmacodynamics
Antimicrobial range of the drug Nadoxin affects aerobic and anaerobic microorganisms, gram (+) and gram (-) bacteria. Nadoxin not only depresses the vital activity of microbes, but also causes their death.
The active component of the drug suppresses the DNA-gyrase, which participates in the production and renewal of bacterial cell DNA. This helps to block the function of multiplication of microorganisms.
Nadoxin is active against staphylococcal strains that exhibit resistance to fluoroquinolone derivatives. Does not detect cross-resistance with other representatives of the quinolone series.
[5]
Pharmacokinetics
The penetration of the active component into the systemic circulation through the surface layers of the skin is minimal. After a single application, serum levels may be approximately 1.7 ng / ml. With repeated applications, a stable content of the drug is observed, which on the fifth day of therapy can be 4.1 ng / ml.
The half-life is slightly longer than 23 hours.
The removal of the active ingredient from the body is carried out through the urinary system.
Dosing and administration
Nadoxin is distributed by a thin layer on the necessary skin areas in the morning and at night.
In the treatment of acne eruptions the drug is applied immediately after cleansing the face, on dry skin.
With average otitis Nadoxin is applied to cotton turuns, which are put into the ear.
The duration of the treatment course can be from 7 to 10 days. If the doctor considers it appropriate, the treatment can be extended for another week.
Nadoxin is used only as an external agent. If the cream gets into the eyes or mucous membranes, then it is recommended to rinse them immediately with warm water.
If the effect of the drug is not obtained within five days, it should be replaced with another one.
Use Nadoxin during pregnancy
Specific and controlled studies regarding the safety of use of the drug Nadoxin during pregnancy and breastfeeding were not conducted.
Experimental experiments that were performed on animals did not reveal a teratogenic or embryotoxic effect of the active component of the drug. Nevertheless, experts recommend refraining from the use of the drug in the period of gestation and breastfeeding.
Contraindications
Side effects Nadoxin
Side effects are relatively rare and may reveal themselves as follows:
- an allergic reaction (allergic dermatitis, urticaria);
- visible irritation, burning of the skin on the site of application, as well as temporary dysfunction of the sebaceous glands;
- redness of the skin, hyperhidrosis.
Side effects can appear at the beginning of treatment and usually go on independently even without withdrawal of the drug. If such symptoms continue to bother, then the drug is canceled.
[8]
Overdose
No cases of drug overdose Nadoxin were observed, since the degree of ingestion of the active ingredient in the circulatory system is minimal. Sometimes it is possible to increase the side effects of an overdose. In this case, symptomatic treatment is carried out along with the withdrawal of the drug.
Interactions with other drugs
Storage conditions
Nadoxin is recommended to be stored at room temperature, in a dark place, away from children's access.
Special instructions
Medication Nadoxin is preferable to prescribe after the study for the sensitivity of pathogens.
Shelf life
Shelf life - up to 2 years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Nadoxin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.