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Nadoxin
Last reviewed: 03.07.2025
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Nadoxin is a medical preparation for local use. ATC code D10AF.
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Indications Nadoxin
Nadoxin is intended for external treatment of the following diseases:
- infectious and inflammatory dermatological pathologies;
- acne;
- inflammation of the follicles (including the superficial form of the disease – sycosis);
- boils;
- otitis media.
The drug can also be prescribed as an additional symptomatic treatment for gonorrheal prostatitis.
In dermatological practice, Nadoxin is used to treat many infectious skin diseases caused by bacteria sensitive to this drug.
Release form
Nadoxin is a cream for application to the skin surface. The product has a uniform consistency and a light, almost white, color. The cream is placed in a tube and cardboard packaging, 10 g in one tube.
1 g of the drug contains the active ingredient Nadifloxacin 10 mg.
Auxiliary ingredients include vaseline oil, alcohol (cetostearyl), alpha-tocopherol, propylene glycol, etc.
Pharmacodynamics
The antimicrobial range of action of the drug Nadoxin affects aerobic and anaerobic microorganisms, gram (+) and gram (-) bacteria. Nadoxin not only inhibits the vital activity of microbes, but also causes their death.
The active component of the drug suppresses DNA gyrase, which is involved in the production and renewal of bacterial cell DNA. This helps block the reproduction function of microorganisms.
Nadoxin is active against staphylococcal strains that exhibit resistance to fluoroquinolone derivatives. It does not exhibit cross-resistance with other representatives of the quinolone series.
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Pharmacokinetics
The penetration of the active component into the systemic bloodstream through the superficial layers of the skin is minimal. After a single application, the level in the blood serum can be approximately 1.7 ng/ml. With repeated applications, a stable content of the drug is observed, which on the fifth day of therapy can be 4.1 ng/ml.
The half-life is just over 23 hours.
The active ingredient is eliminated from the body through the urinary system.
Dosing and administration
The external agent Nadoxin is spread in a thin layer on the necessary areas of the skin in the morning and at night.
When treating acne, the drug is applied immediately after cleansing the face, to dry skin.
For otitis media, Nadoxin is applied to cotton swabs, which are inserted into the ear.
The duration of the treatment course can be from 7 to 10 days. If the doctor deems it appropriate, the treatment can be extended for another week.
Nadoxin is used only as an external agent. If the cream gets into your eyes or on your mucous membranes, it is recommended to immediately rinse them with warm water.
If the drug does not produce any effect within five days, it should be replaced with another one.
Use Nadoxin during pregnancy
Specific and controlled studies on the safety of using Nadoxin during pregnancy and breastfeeding have not been conducted.
Experimental tests conducted on animals did not reveal any teratogenic or embryotoxic effects of the active component of the drug. However, experts recommend refraining from using the drug during pregnancy and breastfeeding.
Contraindications
Side effects Nadoxin
Side effects are relatively rare and may manifest themselves in the following signs:
- allergic reaction (allergic dermatitis, urticaria);
- visible irritation, burning of the skin at the site of application, as well as temporary dysfunction of the sebaceous glands;
- redness of the skin, hyperhidrosis.
Side effects may appear at the beginning of treatment and usually disappear on their own even without discontinuing the drug. If such symptoms continue to bother, the drug is discontinued.
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Overdose
There have been no cases of overdose with Nadoxin, as the degree of penetration of the active ingredient into the circulatory system is minimal. Sometimes, an increase in side effects is allowed in case of overdose. In such cases, symptomatic treatment is carried out along with the drug withdrawal.
Interactions with other drugs
There is no information on drug interactions between Nadoxin and other drugs.
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Storage conditions
It is recommended to store Nadoxin at room temperature, in a dark place, out of reach of children.
Special instructions
It is preferable to prescribe the drug Nadoxin after conducting a study on the sensitivity of pathogenic microorganisms.
Shelf life
Shelf life: up to 2 years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Nadoxin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.