Penzital

Penzital prevents incomplete digestion of food, which allows you to remove the load on the pancreas, and at the same time relieves of disease-causing gas formation, improving the activity of the gastrointestinal tract.

The active element of the drug is the substance pancreatin. This component is released inside the body under the influence of an alkaline environment that forms inside the small intestine, and then turns into a substitute for secretions produced by the pancreas. [1]

Indications Penzital

It is used for such disorders:

• having exocrine pancreatic insufficiency associated with pancreaectomy or chronic pancreatitis;
• conditions after gastroenterological resection procedures;
• achilia;
• gastritis, which has an antacid or hypoacid nature;
• improper diet;
• preparation for performing fluoroscopy;
• dyspepsia associated with hepatic disease ;
• preparation of the gastrointestinal tract for ultrasound.

Release form

The release of the medication is made in tablets, 20, 30 or 100 pieces inside the box.

Pharmacodynamics

Under the influence exerted by pancreatin in relation to food entering the intestine, a full-fledged process of decomposition of fats with complex carbohydrates, as well as proteins to simple elements that are easily absorbed, is realized. [2]

Dosing and administration

The medication should be taken immediately before a meal, but it is also allowed to use it after it. It is forbidden to drink Penzital with liquids that have an alkaline form.

The serving size is selected by the gastroenterologist, taking into account the intensity of the enzyme deficiency, as well as the dietary characteristics of the patient. An adult is usually prescribed 1-2 tablets 3 times a day. It is allowed to increase the daily portion up to 16 tablets.

For children, portions need to be selected only personally. On average, in pediatrics, they are prescribed:

• age 6-9 years - 1 tablet 2 times a day;
• age 10-14 years - 2 tablets 2 times a day.

In the case of overeating of an alimentary nature, an ultra-short treatment cycle can be prescribed - for 1-2 days in the form of a substitute substance. In case of insufficiency associated with the work of the pancreas, Penzital can be used continuously for several years.

• Application for children

Studies affecting the safety and drug efficacy of drugs in pediatrics have not been conducted, which is why it is recommended not to prescribe it to this group.

Use Penzital during pregnancy

Penzital can be administered during pregnancy only if there are strict indications, when the benefits to the woman are more likely than the risks to the fetus.

Contraindications

The main contraindications:

• active phase of pancreatitis or exacerbation of its chronic form;
• strong sensitivity associated with the elements of the drug and pancreatin.

Side effects Penzital

When using the medication, negative symptoms such as hyperuricosuria or -uricemia, irritation in the perianal region, diarrhea, irritation of the oral mucosa, the formation of strictures in some areas of the colon, as well as discomfort in the epigastric zone and nausea, can be observed.

Overdose

In case of pancreatin poisoning, hyperuricemia or -uricosuria develops, and in addition to this, constipation (in pediatrics).

The medication must be canceled, and then the gastrointestinal tract should be flushed and symptomatic actions should be taken taking into account the signs of an overdose.

Interactions with other drugs

Antacids containing Mg, Al or Ca ions weaken the effectiveness of the drug.

The use together with iron substances reduces the absorption of this component.

The combination with antithrombotic drugs weakens the therapeutic effect of these drugs.

The use in combination with aspirin leads to a decrease in its drug effect.

Non-selective substances that slow down the reverse monoamine uptake, when administered together with Penzital, cause dangerous lethargy.

The use simultaneously with m-anticholinergics leads to the potentiation of anticholinergic activity.

Alkaline liquids cause a violation of the pharmacodynamic parameters of the drug.

Storage conditions

Penzital must be stored at temperatures not exceeding 25 ° C.

Shelf life

Penzital can be used within 36 months from the date of manufacture of the therapeutic product.

Analogs

The analogs of the medication are Panzinorm, Panzim Forte, Biozyme, Pancreoflat with Pancreatin, and in addition Gastenorm, Micrasim and Linkreaz with Pancrenorm and Pancreon. In addition, the list includes Mezim, Vestal and Pangrol, Hermital, Zimet and Panzitrat with Neo-Panpur, as well as Creon, PanziKam, Enzistal and Creazim.

Reviews

Penzital is considered a very effective medication that works well for flatulence, stomach severity, as well as any discomfort in the gastrointestinal tract. Based on the reviews, its cost is cheaper than its more popular counterparts, but at the same time it works no worse than them.