Papazole

Papazol is a vasodilator antispasmodic drug.

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Indications Papazole

It is used for the following disorders:

• unstable increase in blood pressure values;
• spasms developing in the area of the abdominal organs;
• paralysis in the peripheral facial nerve;
• spasms affecting the cerebral vessels and arteries.

The drug can also be prescribed in the presence of residual symptoms after a disease such as poliomyelitis.

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Release form

The drug is released in tablets, in quantities of 10, 20, 25, 30, as well as 40, 50 and 60 pieces inside blisters.

The drug Papazol UBF is produced in packs of 10, 20, as well as 30 and 50 pieces.

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Pharmacodynamics

The drug acts on the body with the help of 2 active elements - papaverine with bendazole. The first weakens vascular resistance and reduces blood pressure values - by blocking the enzymes PDE and CPK inside the vessels. The number of Ca inside the cells decreases, and cyclic AMP accumulates, due to which the vasodilator effect of the drug develops. Papaverine also has an antispasmodic effect on the gastrointestinal tract, biliary tract and urinary tract.

Bendazole has a direct effect on the imidazole endings of the smooth muscles of the vascular walls. This allows you to remove spasms, reduce blood pressure and reduce the intracellular amount of Ca. In addition, this element stimulates spinal cord activity and, in the case of prolonged use, plays the role of an immunomodulator. There is also activation of the processes of binding nucleic acids and protein, and the production of antibodies with phagocytosis.

The drug has antispasmodic, vasodilatory and vasodilatory properties. When used in large doses, it has a weak sedative effect.

Papazol reduces blood pressure by reducing the resistance of vascular walls.

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Dosing and administration

The tablets are taken orally. Often the daily dose is 2-6 tablets, which should be taken in 2-3 doses.

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Use Papazole during pregnancy

At the moment, there is too little data regarding the possibility of using the drug during pregnancy. Therefore, it is prescribed with caution and only under the supervision of a doctor.

It should be noted that pregnant women who used Papazol to reduce blood pressure were satisfied with the results obtained.

Contraindications

Among the contraindications:

• presence of an allergic reaction to the medication;
• epilepsy and respiratory depression;
• AV conduction disorders;
• renal and hepatic pathologies;
• presence of TBI or hypothyroidism;
• weakening of intestinal peristalsis processes, and in addition, certain prostate diseases.

Caution is required when using the drug during lactation.

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Side effects Papazole

The use of the drug can lead to hyperhidrosis, nausea, allergy symptoms, and also constipation and heart muscle dysfunction.

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Overdose

In case of poisoning, symptoms of dyspepsia may appear, and the severity of side effects may also increase.

Symptomatic measures are taken to eliminate the disorders.

Interactions with other drugs

Combination with adsorbents is prohibited, as well as with drugs that have astringent and enveloping properties in relation to the gastrointestinal tract.

The effect of the drug is potentiated when combined with tricyclics, reserpine, antispasmodics, sedatives, as well as diuretics and novocainamide.

Papazol reduces the effectiveness of proserin, levodopa and anticholinesterase drugs.

The toxic effect of the drug on the liver is potentiated when used together with nitrofurantoin.

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Storage conditions

Papazol should be kept in a place protected from sunlight. The temperature should not exceed 30°C.

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Shelf life

Papazol can be used for 5 years from the date of release of the drug.

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Application for children

It is prohibited to prescribe the drug to children under 12 years of age.

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Analogues

The analogues of the drug are the drugs Duzofarm, Papazol-LHFZ and Papazol-Darnitsa, as well as Dibazol, Vinoxim MV and Enelbin 100 retard.

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Reviews

Papazol receives many positive reviews regarding its medicinal effect. It is usually used for problems with blood pressure. At high blood pressure, if taken for a long time (1-5 years) and according to medical indications, the medicine acts very effectively.

However, when used by elderly patients with rapid and severe blood pressure surges, the drug may not always have an effective effect.