Pancreatin

Pancreatin, a drug belonging to a group of enzymes, contains a group of enzymes, such as protease, amylase and lipase, which can compensate for the insufficiency of pancreatic excretion, which occurs in diseases that are accompanied by a disruption in the process of digestive pancreatic juice, and also improves digestive function.

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Indications of the pancreatin

Enzyme means Pancreatin is used in such violations:

• VNPZH - exocrine insufficiency of the pancreas (a pathological syndrome that occurs in the chronic form of pancreatitis or cystic fibrosis);
• Chronic sluggish inflammatory-dystrophic processes in the stomach, gallbladder, liver, intestine; conditions resulting from the irradiation or removal of the above organs, which are also accompanied by problems with digestion of food, bloating, diarrhea (with combined treatment);
• Improving the process of digestion of food in patients with normal functioning of the gastrointestinal tract if there are errors in the diet, and in addition, if there are disorders of masticatory function, the patient leads a sedentary lifestyle, with forced long-term immobilization;
• In the process of preparing for the procedure of ultrasound or X-ray examination of the abdominal cavity.

[6], [7], [8]

Release form

Gelatin capsules containing mini-tablets. They contain lipase in a volume of 10/20/25 thousand units; amylase in the volume of 9/18 / 22.5 thousand units; protease in the volume of 500/1000 / 1,250 thousand units.

[9], [10], [11]

Pharmacodynamics

Pancreatin is an enzyme preparation, it contains excretory pancreatic enzymes: trypsin, lipase, chymotrypsin, alpha-amylase. The drug cleaves fats, turning them into fatty acids and glycerin; proteins, turning them into amino acids; starch, turning it into dextrins and monosaccharides. In addition, it stabilizes the digestive process. Affects the body as an anesthetic due to trypsin, which suppresses the stimulated release of pancreatic juice from the pancreas. Up to the maximum value, the enzymatic activity of the drug reaches 30-45 minutes. After oral administration of the tablet.

[12], [13], [14], [15], [16],

Dosing and administration

The medicine must be taken inside 3-6 r. / Day. Before or during meals. Capsules do not need to be chewed, they are washed down with liquid (fruit juice or water). Dosage is prescribed individually, this depends on the severity of the disease, as well as the age of the patient.

For adults, as a single dose, 2-4 capsules are usually prescribed. (50-100 units); a day you need to drink 8-16 caps. (200-400 IU).

Children on average are prescribed a one-time dose of 1 caps. (25 U); age 8-9 years - 1-2 caps. (25-50 units); age 10-14 years - 2 caps. (50 units).

The duration of the treatment course can be several days (if digestive problems have arisen as a result of improper diet) or several months and sometimes even years (if the patient needs regular substitution treatment).

[17], [18]

Use of the pancreatin during pregnancy

There is no definite conclusion regarding the safety of the use of the drug during pregnancy. Therefore, it is recommended to apply it only when the possible benefit of the drug for a woman exceeds the possible risk for her child.

Contraindications

The drug is not recommended for use if the patient has a high sensitivity to the substance pancreatin. It is also contraindicated in the acute form of pancreatitis.

Side effects of the pancreatin

At the use of average medical doses of the drug, side effects occur in less than 1% of cases.

Allergies: sometimes there may be rashes on the skin.

The process of metabolism: if you take Pancreatin in large doses for a long time, you can develop hyperuricosuria. At excessively high dosages, serum uric acid levels may increase.

Other: Drug use in large doses in children can cause perianal irritation.

Interactions with other drugs

In combination with antacids, which contain magnesium hydroxide and / or calcium carbonate, the effectiveness of pancreatin may decrease.

Admission simultaneously with acarbose in theory can reduce its therapeutic effect.

Simultaneous use of Pancreatin together with drugs that improve the iron in the body can lead to a decrease in the absorption of iron.

[19], [20], [21]

Storage conditions

The medicine should be stored in a dry place, closed from the sun, and also inaccessible to small children. The air temperature should not exceed 25 ° C.

[22]

Shelf life

Pancreatin is allowed to be used within 3 years from the date of manufacture.

[23], [24]