Panavir

Panavir refers to the pharmacological group of antiviral immunomodulating agents acting by increasing the synthesis of endogenous interferon in response to infection of the body.

[1], [2], [3], [4], [5]

Indications Panavir

Panavir is intended for use in diseases caused by the herpes simplex virus HSV-1 and HSV-2 of any localization (oral, genital, herpes Zoster); papillomatosis; cytomegalovirus infection; tick-borne encephalitis; infectious mononucleosis caused by the Epstein-Barr virus.

Also, the drug can be used in the complex treatment of various inflammatory diseases of viral, bacterial and fungal etiology.

[6]

Release form

Panavir is available in the form of 0.004% solution for injection (in ampoules or vials of 5 ml), rectal and vaginal suppositories, gel for external use (in aluminum tubes of 3, 5, 10 or 30 g) and a spray for the oral cavity and intimate areas .

[7], [8], [9]

Pharmacodynamics

The active substance of the drug Panavir refers to monoglycosides and is an extract of shoots of the nightshade tuberous (Solanum tuberosum) - potatoes. The extract is a compound of nitrogen-containing steroidal alkaloids - saponins, which protect plants, providing fungicidal, antimicrobial, cytolytic action. The derivatives of coumarin of the benzopyron group contained in the extract are inhibitors of poly (ADP) -ribose) -polymerase, which inhibit the replication of virus genes in the affected tissues. In addition, saponins have immunomodulating properties due to the presence in them of physiologically active polysaccharides (D-galactose, D-xylose, L-rhamnose, L-arabinose).

Pharmacokinetics

After the injection of the injectable solution of Panavir intravenously after a few minutes, significant concentrations of the active substance in the form of high-molecular carbohydrates (polysaccharides) are noted in the blood plasma.

Elimination of Panavir begins approximately 25 minutes after intravenous injection - kidney, with urine.

[10]

Dosing and administration

Suppositories Panavir are applied rectally or vaginally: with herpes - 2 suppositories in 24 or 48 hours. The second course is after 30; with papillomas and cytomegalovirus - the first three suppositories are administered one at a time every 48 hours, 4 and 5 should be administered at intervals of 72 hours.

The solution of Panavir is administered intravenously: for herpes, 5 ml twice (the second injection is given a day or two after the first one); with papillomas and cytomegalovirus, the first three injections of 5 ml are done at intervals of 48 hours, 4 and 5 injections should be done at intervals of 72 hours.

The gel is applied to the affected skin or mucous membrane with a thin layer - five times a day; the standard duration of treatment is 5-10 days.

[13]

Use Panavir during pregnancy

The use of Panavir during pregnancy is only possible according to the doctor's prescription and provided that the expected benefit for the mother is compared with the possible risk to the fetus. In the lactation period, the use of Panavir requires a temporary cessation of breastfeeding.

Contraindications

Panavir is contraindicated to use in the presence of hypersensitivity to the components of the drug, as well as for the treatment of patients of childhood.

[11]

Side effects Panavir

According to the manufacturer, Panavir, as a rule, is tolerated normally, cases of allergic reactions to the drug are of a single nature.

[12]

Overdose

Overdose of Panavir was not noted.

Interactions with other drugs

There were no specific features of Panavir interaction with other drugs.

[14], [15], [16]

Storage conditions

Storage conditions Panavir: Suppositories Panavir should be stored at a temperature of + 2-8 ° C; solution for injection, spray and gel - at + 2-25 ° C;

[17],

Shelf life

Shelf life of suppositories Panavir - 3 years; solution for injection Panavir and gel Panavir - 3 years; spray - 5 years.