Panavir

Panavir belongs to the pharmacological group of antiviral immunomodulatory agents that act by increasing the synthesis of endogenous interferon in response to infection of the body.

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Indications Panavir

Panavir is intended for use in diseases caused by the herpes simplex virus HSV-1 and HSV-2 of any localization (oral, genital, herpes zoster); papillomatosis; cytomegalovirus infection; tick-borne encephalitis; infectious mononucleosis caused by the Epstein-Barr virus.

The drug can also be used in the complex treatment of various inflammatory diseases of viral, bacterial and fungal etiology.

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Release form

Panavir is available in the form of a 0.004% injection solution (in ampoules or vials of 5 ml), rectal and vaginal suppositories, gel for external use (in aluminum tubes of 3, 5, 10 or 30 g) and a spray for the oral cavity and intimate areas.

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Pharmacodynamics

The active substance of Panavir is a monoglycoside and is an extract of Solanum tuberosum shoots - potatoes. The extract is a compound of nitrogen-containing steroid alkaloids - saponins, which protect plants by providing fungicidal, antimicrobial, cytolytic action. The coumarin derivatives of the benzopyrone group contained in the extract are inhibitors of poly(ADP)-ribose) polymerase, which inhibit the replication of viral genes in affected tissues. In addition, saponins have immunomodulatory properties due to the presence of physiologically active polysaccharides (D-galactose, D-xylose, L-rhamnose, L-arabinose).

Pharmacokinetics

After intravenous administration of Panavir injection solution, significant concentrations of the active substance in the form of high-molecular carbohydrates (polysaccharides) are observed in the blood plasma within a few minutes.

Elimination of Panavir begins approximately 25 minutes after intravenous injection – through the kidneys, with urine.

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Dosing and administration

Panavir suppositories are used rectally or vaginally: for herpes - 2 suppositories after 24 or 48 hours. Repeated course - after 30 days; for papillomas and cytomegalovirus - the first three suppositories are administered one at a time every 48 hours, 4 and 5 should be administered at intervals of 72 hours.

Panavir solution is administered intravenously: for herpes - 5 ml twice (the second injection is given one or two days after the first); for papillomas and cytomegalovirus, the first three injections of 5 ml are given at intervals of 48 hours, the 4th and 5th injections should be given at intervals of 72 hours.

The gel is applied to the affected areas of the skin or mucous membrane in a thin layer - five times a day; the standard duration of treatment is 5-10 days.

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Use Panavir during pregnancy

The use of Panavir during pregnancy is possible only upon doctor's prescription and subject to the comparison of the expected benefit to the mother with the possible risk to the fetus. During lactation, the use of Panavir requires temporary cessation of breastfeeding.

Contraindications

Panavir is contraindicated for use in the presence of hypersensitivity to the components of the drug, as well as for the treatment of pediatric patients.

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Side effects Panavir

According to the manufacturer, Panavir is generally well tolerated, and cases of allergic reactions to the drug are isolated.

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Overdose

Overdose of the drug Panavir has not been observed.

Interactions with other drugs

No specific interactions between Panavir and other drugs have been identified.

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Storage conditions

Storage conditions for Panavir: Panavir suppositories should be stored at a temperature of +2-8°C; injection solution, spray and gel – at +2-25°C;

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Shelf life

The shelf life of Panavir suppositories is 3 years; Panavir injection solution and Panavir gel is 3 years; spray is 5 years.