Abipim

Abipim is a broad-spectrum medicinal product. Helps to cure respiratory tract infections, as well as bronchitis and pneumonia. Indispensable in diseases associated with the genitourinary system, infections of the urinary tract, such as pyelonephritis. Helps to cure infections of soft tissues and skin, gynecological infections and bacterial meningitis.

Abipim has several analog preparations, which have similar characteristics and therapeutic properties, among the analogues they use - cefepime, quartzsef, etipim and maxitsef. Analogues of abipim are prescribed only by the attending physician, it is forbidden to choose the drug independently.

[1]

Indications Abipim

Under the indications of the use of abipim means prevention of complications in the postoperative period, empiric therapy of neutropenic fever and sensitive to the preparation of microflora.

Indication for the use of abipim:

• Septicemia.
• Respiratory tract infections, bronchitis and pneumonia.
• Intraabdominal infections.
• Diseases of the skin and subcutaneous tissue.
• Diseases of a gynecological nature.
• Infections of the biliary tract.

Abipim is suitable for both children and adults. Doctors give such indications to the use of abipim for children:

• Bacterial meningitis
• Septicemia
• Pneumonia
• Neurophenic fever
• Skin Infections
• Urinary tract infections

If a patient has a risk of developing severe infections, then in addition to monotherapy with abipim, a full-fledged antimicrobial therapy is prescribed.

[2], [3],

Release form

The form of release of abipim is a powder, which is used for the preparation of injections. Injection capacity: 100 mg, 500 mg, 1000 mg and 2000 mg in bottles 1 and 5.

For injections, two component and three component syringes are used, both small and large. The syringe is selected depending on the injection capacity.

Pharmacodynamics

Pharmacodynamics abipim has a wide spectrum of action, due to the fact that suppression of the synthesis of enzymes of the walls of bacterial cells. Abipim is highly resistant to the process of hydrolysis, has a weak relationship with chromosomal genes and very rapidly penetrates bacterial gram-negative cells.

There is activity of abymers with respect to the following microorganisms:

Gram-positive aerobes:

• streptococci
• hemolytic streptococci
• staphylococci

Anaerobes:

• oral microorganisms

Gram-negative aerobes:

• stamps producing beta-lactamase
• strains producing β-lactamases

Pharmacodynamics abipim is a mechanism that is responsible for the localization of the drug and the effect of drugs that are contained in abipim.

[4], [5]

Pharmacokinetics

The pharmacokinetics of abipim is the process of distribution and assimilation of the drug. Formokokinetics is responsible for the metabolism of abipim in the body, as well as its withdrawal from the body.

Abipim begins to be excreted from the body within two hours. Cumulation of the drug in the body is not observed. Abipim is excreted from the body by the kidneys, which are responsible for the mechanism of regulation of glomerular filtration.

During the research on the pharmacokinetics of abymipoma in patients with renal insufficiency, a prolonged period of excretion of the drug from the body was detected. With kidney damage, the elimination period is 13 to 19 hours. The pharmacokinetics of abipim in patients with liver disease is not treason. The dose of the drug is from 50 mg per 1 kg of body weight, when applied every 8 hours.

[6], [7]

Dosing and administration

Before using abipim, it is very important to make an analysis for the tolerance of the drug, that is, a skin test.

Dosage of the drug for adults - 1 g intramuscularly or intravenously with an interval of 12 hours. Duration of treatment is from 7 to 10 days, with severe infections, a prolonged course of treatment is possible. The dosage of abipim and the method of application depend on the complexity of the infection, the state of the kidneys, and the sensitivity of the microorganisms-pathogens of the infection.

Dosage of abipim for adults:

• Heavy infections - 2 g intravenously, taking the drug every 12 hours.
• Urinary tract infection - 1 g - 500 mg intramuscularly or intravenously, taking the drug every 12 hours.
• Infections that threaten life - 2 g intravenously, taking the drug every 8 hours.
• Infections of medium and light weight - 1 g intramuscularly or intravenously, taking the drug every 12 hours.
• For prophylaxis during surgical operations - 2 g intravenously for 30 minutes an hour before surgery.
• In case of kidney damage, the dose of abipim is selected individually.

Children abipim appointed at the age of 1 to 2 months, from 30 mg per 1 kg of body weight, after 8 or 12 hours, depending on the severity of the disease and infection. Children with a body weight of more than 40 kg abipim, appoint the same parameters as adults. Duration of treatment is from 7 to 10 days.

Use Abipim during pregnancy

Studies on the use of abimine during pregnancy have not been conducted. Therefore, accurately predict the result of treatment and the effect of the drug on the course of pregnancy and fetus is not possible.

Abipim during pregnancy is prescribed only in those cases when the risk to the fetus is not considered, since the benefit of treatment for the mother is important. As for taking abimima by nursing mothers, the drug enters breast milk, although not in large quantities. Therefore, when taking abipim in the postpartum period, you should stop breastfeeding. Babies abipim appoint at the age of one month.

Contraindications

Contraindications to the use of abipim are similar with similar drugs.

• Hypersensitivity to abipim
• Sensitivity to antibiotics of cephalosporin class
• Hypersensitivity to penicillins

Allergic reactions take a special place in contraindications to the use of abipin. The drug can cause serious complications and hypersensitive reactions.

When applying abipim, special attention should be given to the development of pathology and diarrhea throughout the time of taking the drug. The use of abipim can lead to irritation of sensitive microflora, as in the case of other potent antibiotics.

Side effects Abipim

The side effects that are caused by admission are:

• Nausea
• Vomiting
• Colitis
• Diarrhea
• Candidiasis of the oral cavity
• Hypersensitivity
• Hives
• Itching
• Fever
• Headache
• Erythema

In severe cases, possible side effects such as:

• BREAST DISORDER
• Abdominal pain
• Genital itching
• Dizziness
• Constipation
• Candidiasis
• Anaphylaxis
• Paresthesia
• Epileptiform seizures

Studies abibim showed that when the drug is possible to develop phlebitis and inflammation.

Take abipim follows after the appointment of a doctor and under his supervision, accurately observing the dosage, time and rules for using abipim. This will avoid a number of the above-described side effects on abipim.

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Overdose

Abdominal overdose can occur in case of non-compliance with the prescribed dosage of the drug and the time of admission.

Symptoms of an abdominal overdose:

• Hallucinations
• Neuromuscular excitability
• Encephalopathy
• Stupor
• Myoclonia
• Disorders of consciousness
• Cases of coma

To remove symptoms of an overdose of the drug, it is necessary to conduct sympathetic therapy and stop the drug administration. In cases of severe allergic reactions it is necessary to carry out intensive therapy, possibly with the use of adrenaline.

Interactions with other drugs

The interaction of abipim with other drugs is possible, but only under the supervision of the attending physician. If a high dose of aminoglycosides is used simultaneously with abipim, special attention should be paid to the work of the kidneys, since there is a possibility of ototoxicity and nephrotoxicity of aminoglycoside preparations. A similar effect was seen after the interaction of abipim with drugs diuretics.

Abim with a concentration of up to 40 mg / ml interacts with such parenteral solutions:

• 5% glucose solution
• 10% glucose injection solution
• 0.9% solution of nitrile chloride
• A solution of sodium lactate
• Ringer's solution with lactate and glucose.

In order to avoid irreversible reactions and adverse infections, abipim is administered separately from solutions of netilmicin sulfate, metronidazole, gentamicin, or vancomycin. When appointing abipim and any of the above drugs, injections are carried out separately to prevent drug interactions.

[9], [10]

Storage conditions

Store abipim in the original packaging, in an unacceptable place for children, at a temperature of no higher than 25 ° C.

If the conditions for storing abipim are not met, the drug may deteriorate, change its color and properties. It is very important not to mix abipim with other drugs in one container, as this will lead to side reactions of irreversible nature.

Shelf life

Shelf life of abipim is 24 months from the date of manufacture, which is indicated on the vial with the drug. Please note that abipim is a powder from a white to yellowish color, any other color changes indicate a failure to comply with the rules of storage or expiration of the drug. Abim is released only on prescription of the attending physician. Packing the drug - 500 mg powder or 1 g bottle per pack.