Palin

Palin is a member of the pharmacological group of antimicrobial agents – uroseptics, and belongs to the first generation of quinolones, derivatives of naphthyridine. Other trade names of synonymous drugs: Pipemidine, Pipem, Pimadel, Pimidel, Pilamin, Pipelim, Urodipin, Uromidine, Uropimid, Septidron, etc.

Indications Palin

Palin is used in the treatment of acute and chronic inflammatory diseases of the urinary tract, such as cystitis, urethritis, urethral syndrome, chronic pyelonephritis, inflammation of the prostate gland (prostatitis).

Palin can be used to prevent infection during instrumental urological and gynecological examinations, during the installation of catheters after surgery, etc.

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Release form

Release form: capsules of 0.2 g.

Pharmacodynamics

Pharmacological action of Palin - bactericidal and bacteriostatic - is provided by the active substance pipemidic acid (in the form of pipemidine trihydrate). When pipemidic acid gets into the infected area of tissue, due to condensed pyridine rings and cleavage of the nitrile group, it penetrates the cell membrane of bacteria and blocks their enzyme complex.

Inhibition of enzymes that regulate the replication process of pathogenic microorganisms leads to the impossibility of RNA synthesis and the transfer of genetic information from the matrix of the parental DNA molecule of the bacterium. As a result, the process of bacterial division ceases and they die.

Palin is effective against gram-negative bacteria Proteus mirabilis, Escherichia coli, Enterobacter cloacae, Serratia marcescensi, Haemophilus influenzae, Morganella morganii, Klebsiella spр., Citrobacter spр., Alcaligenes spр., Acinetobacter spр.

Pseudomonas, Chlamydia, Mycobacterium bacteria, as well as gram-positive bacteria are resistant to this drug.

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Pharmacokinetics

Palin is absorbed in the gastrointestinal tract and after 1-1.5 hours after administration reaches its maximum concentration in the body, and after 4-5 hours - in the urine. Up to 30% of the active substance binds to plasma proteins, the level of bioavailability of the drug does not exceed 60%.

Palin does not undergo transformation, up to 85% is excreted by the kidneys unchanged - with urine, the rest is excreted by the intestines.

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Dosing and administration

The drug is taken orally, the tablets should be swallowed whole and washed down with a glass of water. The dosage and duration of the course of treatment are determined by the attending physician. The standard dose is 0.4 g (two capsules) twice a day (with equal intervals between doses). The duration of Palin use is 10 days.

During treatment with this drug, it is recommended to increase the amount of fluid consumed.

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Use Palin during pregnancy

The use of Palin during pregnancy and lactation is contraindicated.

Contraindications

Contraindications to the use of the drug are pathologies of the central nervous system, accompanied by involuntary muscle contractions (epilepsy, etc.); porphyria; severe dysfunction of the kidneys and liver; children under 14 years of age.

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Side effects Palin

The use of Palin may be accompanied by side effects in the form of decreased appetite, nausea, vomiting, diarrhea, constipation, abdominal pain, skin rashes, increased skin sensitivity to ultraviolet light, joint and headaches, anemia, thrombocytopenia, tremor, sleep disorders. Quincke's edema and anaphylactic shock are possible.

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Overdose

Palin causes headache, dizziness, nausea and vomiting, tremors, convulsions. In case of overdose, gastric lavage should be performed and activated carbon or another enterosorbent should be taken. If convulsions occur, it is advisable to use anticonvulsants (diazepam).

Interactions with other drugs

Palin should not be combined with nitrofuran antibacterial agents (furazolidone, furazidine, nitrofuran, etc.); the use of Palin with other naphthyridine derivatives may increase the likelihood of seizures.

Antacids, bismuth, iron and zinc preparations should be taken 4-6 hours before taking Palin, or 2 hours after taking it.

When Palin is taken in parallel with such drugs as cimetidine, warfarin and rifampicin, the effect of the latter on the body is enhanced.

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Storage conditions

Storage conditions for Palin: in a place protected from light, at room temperature.

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Shelf life

The shelf life of the drug is 5 years.