Overspan for cough: what kind of cough to take, analogues

The herbal preparation Prospan for cough belongs to the group of expectorants and mucolytics, that is, it is an expectorant. 

Indications Sleepy with cough

What kind of cough is Prospan used for? Like many other expectorant and mucolytic drugs, doctors prescribe Prospan for wet cough (productive) - in the symptomatic treatment of various infectious diseases of the upper respiratory tract, as well as acute and chronic bronchitis, which are accompanied by coughing with the formation of viscous bronchial exudate (sputum).

Release form

The manufacturer (Engelhard Arzneimittel GmbH & Co, Germany) produces:

• cough syrup Prospan (in bottles of 100 ml and 200 ml);
• effervescent tablets Prospan forte (65 mg each);
• cough drops Prospan (20 ml in a bottle);
• cough lozenges Prospan (26 mg each);
• cough solution Prospan (for oral administration) in sticks of 5 ml.

Pharmacodynamics

Dry extract of common ivy leaves (Hedera helix L.) of the Araliaceae family is the active substance of all forms of the Prospan cough remedy.

Its pharmacological action - secretolytic (thinning sputum) and expectorant (improving mucociliary clearance and facilitating expectoration of sputum) - is due to such organic compounds as the pentacyclic triterpenoid hederagenin (systematic name - (3β) -3,23-dihydroxyolean-12-en-28- oic acid), which is a triterpene saponin, as well as the glycoside α-hederin (also related to terpene saponins). [1].  [2].  [3]. [4]

According to studies, hederagenin has hydroxyl, hydroxymethyl and carboxyl groups in its structure, which reduce the viscosity of bronchial secretions by increasing its hydrophilicity; is rapidly absorbed in the gastrointestinal tract, can cross the blood-brain barrier and has a short half-life. 

Pharmacokinetics

In the instructions for all forms of this drug, pharmacokinetics is not described, since it, due to the complexity of the structure of biologically active substances, has not been fully studied. However, the researchers suggest that hederagenin is metabolized mainly by intestinal microflora.

Dosing and administration

Dosage of syrup for adults: three times a day, 5-7.5 ml; for children 6-12 years old - 5 ml; children under six years old - 2.5 ml.

Dosage of Prospan solution for adults and children over 12 years old: one stick (undiluted with water) - three times a day; children 6-11 years old - twice a day, one stick.

Drops Prospan adult children over 12 years of age take 20 drops (three to four times a day); children two to three years old - 10 drops per reception; children under 12 - 15 drops.

Effervescent tablets (to be dissolved in 200 m of water) for adults and children over 12 years old are recommended to take one tablet twice a day; children 7-12 years old - half a tablet three times a day.

• Application for children

See -  Prospan cough syrup for children

Children under one year do not use Prospan drops, and children under six years of age do not use effervescent tablets and Prospan solution.

Use Sleepy with cough during pregnancy

During pregnancy and lactation, the use of Prospan in any form of release is not recommended.

Contraindications

Prospan syrup is contraindicated in the presence of congenital fructose malabsorption, glucose-galactose malabsorption and sucrose deficiency.

The drug is not prescribed for bronchial asthma.

Side effects Sleepy with cough

The most likely side effects of ivy leaf extract products are nausea, vomiting and diarrhea, as well as allergic reactions (skin flushing, angioedema and shortness of breath).

Overdose

Exceeding the dosage leads to gastrointestinal disorders with nausea, vomiting and diarrhea.

Interactions with other drugs

Prospan cough should not be taken with drugs that suppress the cough reflex.

Storage conditions

Prospan should be stored at a temperature not exceeding + 25 ° C, avoiding sunlight.

Shelf life

The shelf life is three years, but an opened bottle of syrup reduces the shelf life to three months.

Analogues

Prospan's analogues are: syrups Gederal ivy, Gerbion ivy, Ritosse ivy, Bronchipret; Pectolvan ivy (syrup and capsules); syrup and drops Gedelix; syrups Lazolvan (Ambroxol), Fludex, etc.