Omez

Omez is an effective antiulcer drug from the proton pump inhibitor group. The main component of the drug is omeprazole.

[1], [2]

Indications of the omez

Among the main indications for prescribing:

• Erosive-ulcerative form of esophagitis;
• Peptic ulcers in the area of the duodenum or stomach;
• Ulcers of the above-mentioned organs that arose as a result of taking non-steroidal anti-inflammatory drugs;
• Stress caused by ulcers;
• Pancreatitis in acute and chronic form;
• Repeated, recurrent peptic ulcer having duodenal or gastric placement; the patient is prone to complications (the treatment is aimed at preventing relapse);
• Zollinger-Ellison syndrome;
• In the process of complex treatment for the eradication of Helicobacter pylori;
• GERD (treatment to prevent relapse);
• Acute mast cell leukemia.

[3], [4], [5]

Release form

Omez is released in capsules (in each of 20 mg of the main component (omeprazole)). In one packet 10 or 30 capsules.

Omez 40 is a dried powder from which a solution for injections is prepared. One bottle contains 40 mg of the basic substance.

[6], [7]

Pharmacodynamics

Omeprazole is a substance in the group of inhibitors of the proton pump, it slows the activity of the enzyme H + - K + - ATPase in the gastric lining cells. Thus, it blocks the final stage of hydrochloric acid evolution. As a result, the basal and stimulated release of pepsinogen and gastric juice, both day and night, is inhibited. Omeprazole after a one-time procedure begins to work in the first hour, and its effect lasts for a day. The maximal efficiency reaches 2 hours. In patients with duodenal ulcer, 20 mg of substance allow for maintaining the level of intragastric pH at the level of 3.0. With the termination of taking the drug, the release of hydrochloric acid by parietal cells is restored to the normal level after 3-5 days. 

[8]

Pharmacokinetics

Omeprazole is a substance in the group of inhibitors of the proton pump, it slows the activity of the enzyme H + - K + - ATPase in the gastric lining cells. Thus, it blocks the final stage of hydrochloric acid evolution. As a result, the basal and stimulated release of pepsinogen and gastric juice, both day and night, is inhibited. Omeprazole after a one-time procedure begins to work in the first hour, and its effect lasts for a day. The maximal efficiency reaches 2 hours. In patients with duodenal ulcer, 20 mg of substance allow for maintaining the level of intragastric pH at the level of 3.0. With the termination of taking the drug, the release of hydrochloric acid by parietal cells is restored to the normal level after 3-5 days. 

[9], [10], [11], [12], [13]

Dosing and administration

Intravenous injection of the drug with GERD or development of peptic ulcer having a duodenal or gastric location is administered in an amount of 40 mg / day. For an adult.

The initial dose of the drug in the syndrome of Zollinger-Ellison is 60 mg / d, but this index may increase. If the daily dose of omeprazole is more than 60 mg, it is recommended to divide it into 2 doses.

The initial dose of the drug in peptic ulcers, accompanied by bleeding in the GI tract, will be 80 mg / day intravenously. Further, starting from the 3rd day of the treatment course and until the 21st day, the drug is taken orally - 20 mg / d.

For treatment of hepatic insufficiency it is possible to prescribe the drug in a dosage of a maximum of 10-20 mg. Intravenous injection should be administered for 20-30 minutes. To make a batch, the powder contained in 1 bottle is added to a 5% injection of dextrose or 0.9% sodium chloride solution (100 ml). Such a solution can be used for 1 day, no more.

Oral administration of Omez capsules. They are consumed whole, not chewing. To treat peptic ulcers with duodenal or gastric localization, as well as reflux esophagitis, a dosage of 20 mg / day before breakfast is prescribed. Therapeutic course lasts 14 days. If the two-week treatment was ineffective (the peptic ulcer did not heal), the course is prolonged for another 2 weeks (until the final scarring occurs). Often, peptic ulcers in the area of the duodenum after the application of Omez (40 mg / day) are cured for 1 month, and reflux esophagitis in erosive form or gastric ulcers - for 2 months.

For effective treatment of Zollinger-Ellison syndrome, the drug for internal use is administered at a dosage of 60 mg / d. The duration of the treatment course will depend on what the clinical picture of the disease is. The maintenance dose can fluctuate within the limits of 20-120 mg / day - exact figures individually for the patient are determined by the attending physician. If the required daily dose of Omez is more than 80 mg, the medication is divided by 2 times.

[19], [20]

Use of the omez during pregnancy

It is forbidden to prescribe Omez to pregnant or lactating mothers.

Contraindications

Medication is contraindicated if the patient is allergic to omeprazole or other active ingredients of the medication.

[14], [15], [16], [17]

Side effects of the omez

Among the side effects of medication:

Nervous system: intense sweating, dizziness and severe headaches, frequent drowsiness or insomnia, increased excitability, paresthesia, vision problems, depressive state and the occurrence of hallucinations in patients with a predisposition to them.

Gastrointestinal tract: diarrhea, stomatitis, pain in the abdomen, discomfort in the work of taste buds, dry mouth, constipation, temporary increase of transaminases in blood serum, as well as liver samples.

Musculoskeletal: muscle pains and weakness in muscles, joint pain.

Skin: the appearance of skin rashes or hives, the development of polymorphic erythema.

Other: the occurrence of peripheral edema, fever.

[18]

Overdose

As a result of an overdose, symptoms such as arrhythmia, nausea, confusion, as well as an increase in the above side effects can occur.

Interactions with other drugs

Since the enzyme cytochrome P450 is involved in the metabolism of the drug in hepatocytes, it must be used with caution when taking warfarin and phenytoin, as well as diazepam. In such combinations, omeprazole will reduce the rate of excretion of metabolites of these drugs, because of which it is necessary to reduce their dose.

When omeprazole is combined with clarithromycin, an increase in the concentration of both substances in the plasma is observed.

[21]

Storage conditions

The drug should be stored in a temperature of no more than 25 ° C, in a dry place, protected from sunlight.

[22], [23]

Shelf life

Omez is usable for 36 months from the date of release.

[24], [25],