Neuromultivit

Neuromultivit is a medicinal subgroup of combined vitamin substances. It acts by stimulating metabolic processes in the CNS and helps restore nerve tissue.

The medicinal product contains neurotropic active elements from the B-vitamin subcategory, which are coenzymes and participate in the development of intermediate metabolic processes occurring within the PNS, as well as the CNS.

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Indications Neuromultivita

It is used for disorders of a neurological nature - as part of a combination treatment. Among these:

• neuralgia affecting the area of the trigeminal nerve;
• polyneuritis of various etiologies (including alcoholic or diabetic polyneuropathy);
• neuritis (inflammatory pathologies affecting peripheral nerves);
• intercostal neuralgia;
• lumbago, sciatica or lumbosciatica;
• plexitis affecting the cervical, as well as the shoulder or lumbosacral region;
• radiculopathy, which appears as a result of degenerative vertebral pathologies;
• neuropathy affecting the facial nerve (this includes prosoplegia and Bell's palsy).

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Release form

The pharmaceutical element is produced in tablets - 20 pieces are packed in a cellular package. There is 1 such package in a box.

Pharmacodynamics

The active ingredients of the drug (cyanocobalamin with thiamine and pyridoxine) have an analgesic effect, due to which they can be used not only in conditions with vitamin deficiency, but also for the treatment of diseases that are not related to such disorders or metabolic disorders (among them are psychosis, mononeuropathy, pain, polyneuritis, carpal tunnel syndrome, etc.).

B-vitamins are very important nutritional components that cannot be formed independently within the body.

When consuming thiamine with cyanocobalamin, and in addition pyridoxine, the deficiency of these vitamins caused by their deficiency in the food products consumed is replenished, and the presence of the required volume of coenzymes in the body is also ensured.

Medicinal use of B-vitamins for various lesions of the nervous system is required, firstly, to compensate for the existing vitamin deficiency (which may be associated with the increased need of the body due to illness), and, secondly, to stimulate natural recovery processes.

The active components of the drug have low toxicity, which is why it is considered safe for humans.

Exogenous thiamine, when phosphorylated, is converted inside the human body into the component cocarboxylase, which is a coenzyme of most enzymatic reactions and also catalyzes decarboxylation together with carboxylation of α-keto acids.

Thiamine is very important in regulating the metabolism of lipids and carbohydrates with proteins. At the same time, it participates in the conduction of neuronal impulses within synapses.

Pyridoxine helps maintain stable functioning of the PNS and CNS. The phosphorylated form of the substance is involved in the exchange processes of coenzyme amino acids (for example, it is a participant in transamination reactions, as well as decarboxylation).

Pyridoxine is a coenzyme of enzymes that are essential for the human body and act within the nervous tissues, and at the same time it participates in the biosynthesis of biogenic amines from neurotransmitters. It also helps bind with GABA, norepinephrine, histamine, and also adrenaline and dopamine.

Cyanocobalamin is required to support hematopoietic activity – for example, it is needed for stable maturation of red blood cells. In addition, the substance participates in individual biochemical processes, stimulating the overall vital activity of the body: methylation (movement of methyl categories from SAM to the area of specific DNA zones), metabolism of lipids, amino acids and carbohydrates, as well as binding of proteins to nucleic acids.

At the same time, it affects the processes occurring within the NS (including DNA binding, as well as RNA) and the lipid structure of cerebrosides together with phospholipids. The components methylcobalamin with adenosylcobalamin, which are coenzyme forms of cyanocobalamin, actively participate in cellular replication and growth.

Pharmacokinetics

Pyridoxine, together with thiamine and cyanocobalamin, are water-soluble substances, which is why they do not accumulate in the body. The absorption of the first two elements occurs in the upper intestine, and its severity is determined by the size of the drug dosage.

The absorption and distribution of cyanocobalamin is mainly dependent on the presence of endogenous factors within the gastrointestinal tract.

The metabolic processes of all active elements of the drug are carried out inside the liver.

Excretion of pyridoxine with thiamine is carried out through the kidneys (8-10% of these components are excreted unchanged). In case of poisoning, intestinal excretion of these vitamins increases significantly.

Cyanocobalamin is mainly excreted in bile, and the intensity of its excretion through the kidneys can vary, ranging from 6-30%.

Dosing and administration

The medication is taken orally. It is forbidden to chew or otherwise crush the tablet taken orally - so as not to disrupt its pharmacokinetic parameters.

To achieve maximum medicinal effect, the tablets should be taken immediately after eating. They should be washed down with plain water.

The duration of the treatment cycle and the size of the dosage portions are selected by a medical specialist.

Taking into account the patient’s condition, the intensity of the symptoms of the disease and concomitant treatment, take 1 tablet of the drug 1-3 times a day.

In increased doses, the medication is allowed to be used for a maximum of 1 month in a row.

Children should take 3 tablets of Neuromultivit per day - 1 tablet 3 times per day, after meals. The drug is washed down with a small amount of plain water.

When administered to an infant under 1 year of age, the 1-time dose is reduced to a quarter of a tablet; it should be taken 2 times a day. If the infant is not yet able to swallow the tablet, it can be crushed and then mixed in a spoon with formula or breast milk.

Children can also take the medicine for a maximum of 1 month; otherwise, there is a risk that the child will develop complications of a neurological nature.

The drug should not be given to a child before bedtime, because it increases the excitability of the central nervous system, as a result of which he may develop insomnia.

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Use Neuromultivita during pregnancy

Neuromultvit should not be used during pregnancy or lactation.

Contraindications

Main contraindications:

• severe sensitivity associated with drug elements;
• diseases of allergic etiology (for thiamine);
• an ulcer in the gastrointestinal tract that is in the acute phase (for pyridoxine, because its use in this pathology can cause an increase in gastric pH values);
• erythrocytosis or erythremia, and in addition thromboembolism in the area of the blood vessel bed (for cyanocobalamin).

Side effects Neuromultivita

Neuromultivit is generally tolerated without complications. Although sometimes patients have reported nausea, tachycardia or signs of allergy (such as itching and epidermal rash).

If any negative symptoms occur, you should immediately stop using the medication and consult your doctor.

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Overdose

Using the medication in excessively high doses may increase the likelihood of adverse symptoms.

Neuromultivit has no antidote. If symptoms of poisoning occur, the drug should be discontinued. Symptomatic procedures are performed if necessary.

Interactions with other drugs

The effect of thiamine is inactivated by 5-fluorouracil. This is due to the fact that the latter can competitively slow down the phosphorylation of the vitamin in cocarboxylase.

Combination with antacids leads to deterioration of thiamine absorption.

With prolonged use of loop diuretics (including furosemide), which have a slowing effect on tubular reabsorption, the elimination of thiamine may increase, causing its levels to decrease.

Combined administration of the drug with substances that have an antagonistic effect relative to pyridoxine (for example, anti-tuberculosis drugs - cycloserine or isoniazid, as well as the vasodilator hydralazine and the detoxifying drug penicillamine), and also with oral contraception, increases the need for pyridoxine.

The use of pyridoxine together with levodopa may weaken the medicinal activity of the latter.

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Storage conditions

Neuromultivit should be stored in a dark and dry place, out of the reach of children. Temperature marks - within 25°C.

Shelf life

Neuromultivit can be used for a 3-year period from the date of sale of the medicinal substance.

Application for children

It is prohibited to administer the medicine to children under 12 years of age, because there is no information regarding medicinal efficacy and safety. However, Neuromultivit is used quite often in pediatrics.

According to medical reviews, it can be determined that the drug is prescribed to children over at least 1 year of age, because the amount of vitamins in its composition significantly exceeds the daily requirement of an infant (approximately ten times). When using the drug in newborns or infants up to 12 months, hypervitaminosis may develop.

If there is no alternative to treatment with this drug, a decision about its use can only be made after a full examination of the child, as well as collecting anamnesis.

Neuromultivit actively participates in the metabolic processes occurring inside cells, restoring their activity and having a positive effect on the state of the nervous system.

Pyridoxine is very important for the child's psyche, because it is considered an irreplaceable source of energy: it promotes amino acid metabolism, neurotransmitter binding and transmission of neural impulses. Cyanocobalamin helps saturate various organs and tissues with oxygen.

The drug is used in children with increased physical and, at the same time, neuropsychic stress, in cases of neuralgia of various origins and with improper or inadequate nutrition.

Analogues

The analogs of the drug are the drugs Pentavit and Medivitan with Angiovit, as well as Multi-tabs B-complex, Multi-tabs Intensive and Beviplex.