Nazol

Intranasal spray Nazol is a topical agent prescribed for the treatment of rhinitis. According to the ATX classification, according to the active substance, Nazol is assigned the code R01A A05.

Indications Nazol

Nazol is prescribed to relieve symptoms of acute rhinitis:

• for nasal discharge (mucous, mucopurulent);
• for the treatment of vasomotor rhinitis;
• for the treatment of allergic rhinitis;
• for swelling of the mucous membranes of the nasal cavity and sinuses, for sinusitis.

In addition to treatment, Nazol can be used to prepare the patient for therapeutic and prophylactic manipulations in the nasal cavity.

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Release form

The intranasal drug Nazol is available in aerosol plastic bottles with a dispenser, 15 or 30 ml, packed in a cardboard box.

1 ml of the preparation contains:

• oxymetazoline hydrochloride – 500 mcg;
• Additional ingredients include benzalkonium chloride, benzyl alcohol, macrogol, povidone, propylene glycol, etc.

Nazol is listed as an over-the-counter drug.

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Pharmacodynamics

Nazol is a drug from the category of external vasoconstrictor drugs. The active ingredient oxymetazoline has an α-adrenomimetic property, as it is a synthetic adrenomimetic.

Nazol successfully blocks rhinorrhea - nasal discharge of any etiology, including allergic. Active oxymetazoline instantly constricts superficial vessels, reduces signs of tissue swelling, facilitates breathing through the nose and restores the perception of odors. At the same time, blocked nasal sinuses open, and free breathing is resumed.

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Pharmacokinetics

Oxymetazoline acts 10-15 minutes after application of the drug to the mucous membranes. The duration of the vasoconstrictive effect is approximately 12 hours.

Systemic distribution of the active component is insignificant. Excretion occurs through the urinary and digestive systems. The half-life is from 5 to 8 days.

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Dosing and administration

Nazol is applied by intranasal administration. The spray tip is inserted shallowly into each nasal passage and the spray is pressed with a finger while inhaling deeply through the nose.

It is not necessary to tilt your head back when using the spray.

For children over 6 years of age and adults, 1-3 injections are administered into each nostril.

The frequency of application of the drug is twice a day, in the morning and at night. The duration of the treatment course is a maximum of 3 days.

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Use Nazol during pregnancy

The use of the drug Nazol by pregnant women is not recommended. If it is necessary to use this drug, the recommended doses of the drug should be followed, carefully assessing the possible risks to the developing fetus.

During breastfeeding, oxymetazoline-based products should be used with great caution, and it is better to avoid them altogether.

Contraindications

• Individual hypersensitivity to oxymetazoline, tendency to allergy to other components of Nazol.
• Atrophy of the nasal mucosa.
• Treatment with MAO inhibitors or other drugs that increase blood pressure.
• Glaucoma, increased intraocular pressure.
• Acute myocardial infarction, stroke, hypertensive crisis.
• Pregnancy and lactation period.
• Heart rhythm disorders.
• Pheochromocytoma.
• Metabolic disorders (thyroid disease, diabetes).
• Prostatic hyperplasia.
• Children under 6 years old.

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Side effects Nazol

With frequent and prolonged use of Nazol spray, the following effects may develop:

• itching and burning sensation in the nasal cavity;
• dryness of the nasal mucosa;
• habitual nasal congestion;
• increased heart rate, increased blood pressure;
• conjunctivitis;
• dyspepsia;
• allergic reactions (rash, urticaria, angioedema);
• atrophic changes in the mucous membrane, frequent nosebleeds;
• sleep disorders, irritability;
• increased fatigue, headaches.

After completion of treatment, side effects usually disappear on their own.

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Overdose

When using Nazol spray for more than four days, as well as in case of accidental ingestion of the medicinal solution, the following signs of overdose may be observed:

• peripheral vascular spasms;
• attacks of nausea and vomiting;
• CNS depression;
• heart rhythm disturbances;
• cardiac insufficiency;
• collapse;
• increased sweating;
• pulmonary edema, respiratory dysfunction;
• paleness of the skin;
• convulsions, nervous disorders, strong emotional arousal.

Often, an overdose is characterized by depression of the central nervous system, which manifests itself as fatigue, drowsiness, a drop in blood pressure, and the development of a comatose state.

If the drug is swallowed, it is recommended to wash out the stomach and take sorbent preparations (activated carbon, sorbex, etc.).

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Interactions with other drugs

When used in combination with other drugs that can constrict blood vessels, increased side effects may occur, in particular, increased blood pressure.

Oxymetazoline worsens the effect of other nasal solutions and prolongs their absorption period, and also enhances the effect of MAO inhibitors on the nervous system.

Long-term use of Nazol is undesirable, as it can provoke the development of atrophic changes in the mucous epithelial tissue. For the same reasons, several vasoconstrictors should not be used simultaneously.

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Storage conditions

Nazol should be stored in a dark place, away from children's reach. The optimal temperature for preserving the medicine is from +2 to +25°C.

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Shelf life

The shelf life of Nazol spray is up to 3 years.

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