Nasoline

Medicinal external medicine Nazolinum is intended for intranasal topical use, in the treatment of the common cold and exudation from the nose of various etiologies. According to the ATX classifier, Nazolin is assigned code R01A A08. 

[1]

Indications of the nasoline

Nasoline can be prescribed for the treatment of the following diseases and conditions:

• runny nose, accompanying ARVI or ARI;
• vasomotor runny nose;
• an allergic rhinitis;
• salpingoitis;
• nose bleed;
• edema of the nasal cavity, sinusitis or sinusitis.

In addition, Nazolinum can be used to prepare for conducting diagnostic procedures or operations in the nasal cavity.

[2]

Release form

Intranasal drops of Nazoline are available in polymer bottles with a dosing cap, 10 ml of 0.05% of the drug. Drops have the appearance of a clear solution, without any specific flavor. Each flacon is packed in a separate cardboard box.

 In 1 ml of drops contains:

• naphazoline nitrate - 1 mg or 0.5 mg;
• Additional components are represented by boric acid and purified water.

Pharmacodynamics

Nasoline drops have an external vasoconstrictor effect. The active ingredient naphazoline is synthetic α-adrenomimetic, which activates adrenoreceptors located in the smooth muscles of the vessels of the nasal cavity.

Nasoline stops nasal secretions of any origin. The active substance nafazolin rapidly narrows the surface vessels, reduces the signs of swelling of the mucous membranes, ensures the outflow of blood from inflamed tissues.

[3]

Pharmacokinetics

Nafazolin begins to act immediately after application of the drug on the mucous membranes. The maximum effect is detected after 15 minutes. The duration of the vasoconstrictive effect is up to 6 hours.

Systemic absorption of the active component is insignificant and does not adversely affect the healthy organism. The total period of systemic action may be less than 10 minutes. With prolonged treatment with Nazolin, a cumulative effect of the drug is found.

Dosing and administration

Drops Nazolinum apply as follows:

• adults and children from six years drip 1-2 drops of 0.05% Nazoline up to 3 times a day;
• children 1-6 years drip 1-2 drops of 0,05% Nazoline up to 3 times a day.

The duration of the treatment course is 5 days. If necessary, the course can be repeated after 2-3 days.

When bleeding from the nose, apply a tamponade using 0.05% of the drug.

When carrying out procedures and manipulations in the nasal cavity, apply up to 4 drops of 0.1% of the drug in combination with anesthetic drops.

Immediately before instillation of the drug flacon should be warmed in the hands, so that the solution acquired body temperature.

[5]

Use of the nasoline during pregnancy

Use Nazolin in women during childbirth is not recommended. Sometimes the drug can be prescribed only after a thorough assessment of the likely danger for the course of pregnancy and fetal development. In this case, you should especially carefully follow the recommended doses of medication.

In the period of lactation, Nazolinum can not be used, since its active substances enter the breast milk.

Contraindications

• Hypersensitivity to naphazoline, a tendency to allergic reactions to other components of Nazolin.
• Diseases associated with metabolic disorders (thyroid disease, diabetes mellitus).
• Increased intraocular pressure.
• Chronic inflammation of the mucous membranes of the upper respiratory tract.
• Myocardial ischemia, hypertension, cardiac insufficiency.
• Pronounced atherosclerotic vascular changes.
• Children under one year of age.

[4]

Side effects of the nasoline

With prolonged use of Nazolinum, the following side effects may develop:

• soreness, itching and burning in the nasal cavity;
• redness and swelling of the nasal mucosa;
• tachycardia, increased blood pressure, heart pain;
• allergic manifestations (rash, hives, angioedema);
• nausea;
• headache.

To avoid side effects it is not recommended to use Nazolinum for a long time, and also to exceed recommended doses. After the end of treatment, the mucosal structure is restored in most cases.

Overdose

When using Nasoline over recommended doses, there may be signs of overdose:

• spasms of peripheral vessels;
• heart rhythm disorders;
• hypothermia;
• increase in blood pressure.

In severe cases, symptomatic treatment with adrenolytics and sympatholytic drugs is carried out, but only after Nazolin's complete withdrawal.

Interactions with other drugs

In complex treatment with other means that can narrow the blood vessels, there may be an increase in side effects.

Nazonol blocks the absorption of other nasal drops and prolongs the period of their action, and also increases the effect on the CNS of MAO inhibitor drugs.

It is not recommended to use several external vasoconstrictors simultaneously.

[6]

Storage conditions

Nasolin is recommended to be stored in dark places, away from children's access places. The optimum temperature regime for the preservation of the solution is from + 20 ° C to + 25 ° C.

Shelf life

The shelf life of packaged drops of Nazolinum is up to 1 year. The opened bottle is to be stored for no longer than 28 days.