Nazo Spray

Intranasal Naso-spray is intended for topical use, for the treatment of all kinds of colds. According to the ATX-classifier, the medication is assigned code R01A A05. 

Indications Nazo Spray

Nazo-spray is prescribed in the complex treatment of rhinitis of different origin:

• with discharge from the nose of an infectious nature;
• for treatment of a vasomotor runny nose;
• for the treatment of an allergic rhinitis;
• with swelling of the nasal cavity and nasal sinuses, sinusitis or sinusitis;
• with average otitis;
• with hay fever.

In addition to these indications, Nazo-Spray can be used to prepare for a rhinoscopy or surgical manipulation in the nasal cavity.

[1], [2]

Release form

Intranasal drug Nazo-Spray is available in aerosol plastic or glass bottles with a dispenser, 15 ml each, packed in a cardboard box.

 In 1 ml of the drug contains:

• oxymetazoline g / x - 0.5 mg;
• additional ingredients are represented by benzalkonium chloride, camphor, menthol, eucalyptol, trilon B, etc.

Means Nazo-Spray refers to the category of OTC medicines.

[3], [4], [5]

Pharmacodynamics

Nazo-Spray is a remedy from a group of external vasoconstrictor drugs. The active ingredient oxymetazoline has an α-adrenergic property, being a synthetic adrenomimetic.

Naso-spray stops the discharge from the nose of almost any etiology. Active oxymetazoline rapidly narrows the vessels at the local level, reduces the signs of swelling of the tissues, facilitates breathing through the nose and restores the olfactory function.

The use of the drug does not violate mucociliary clearance, and the functional properties of the mucosal upper respiratory tract are soon resumed.

[6], [7], [8]

Pharmacokinetics

Oxymetazoline shows its effect immediately after application of the drug to the mucous membranes. The duration of the vasoconstrictive effect is approximately 12 hours.

The systemic distribution of the active component is negligible. Excretion is carried out through the urinary and digestive system. The half-life is from 5 to 8 days.

[9], [10], [11]

Dosing and administration

The naso spray is applied by intranasal administration, which is carried out as follows:

• remove the protective cap from the bottle;
• inject the spray tip shallowly into the nasal passage and press the spray pad with the finger pad while simultaneously taking a deep breath through the nose;
• tilt head when using a spray is optional;
• after use, close the spray tip with a protective cap.

Children after 6 years and adults are given one injection in each nostril opening. It is not recommended to carry out more than one injection at a time.

The frequency of application of the drug is 1 time per 10-12 hours. The duration of the treatment course is 5-7 days as much as possible.

[16], [17]

Use Nazo Spray during pregnancy

Use of Nazo-Spray by pregnant women is not recommended, but is allowed. In this case, the recommended doses of the drug should be adhered to, carefully assessing the likely risks to the developing fetus.

In the period of breastfeeding, use of oxymetazoline is necessary with great care.

Contraindications

• Individual sensitivity to oxymetazoline, a tendency to allergic to other components Nazo-Spray.
• Atrophic changes in the mucous membranes of the upper respiratory tract.
• Acceptance of agents-inhibitors MAO, or other drugs that increase blood pressure.
• Glaucoma, increased intraocular pressure.
• Myocardial ischemia, hypertension, acute pathology of cardiac activity.
• Significant atherosclerotic changes in the vessels.
• Heart rhythm disorders.
• Pheochromocytoma.
• Disturbed metabolism (thyroid disease, diabetes mellitus).
• Hyperplasia of the prostate.
• Children under 6 years.

[12], [13]

Side effects Nazo Spray

With frequent and prolonged use of Naso Spray, the following effects are possible:

• feeling of discomfort, itching and burning in the nasal cavity;
• excessive dryness of the nasal mucosa;
• stuffiness in the nose, medicated rhinitis;
• increased heart rate, increased blood pressure, coronary pain;
• conjunctivitis;
• bouts of nausea;
• allergic manifestations (rash, hives, angioedema);
• atrophic changes in the mucosa, repeated bleeding from the nose;
• sleep disorders, irritability;
• increased fatigue, headaches.

After the end of treatment, the structure of the mucosa has the property of recovering. In this case, the function of respiration is resumed.

[14], [15]

Overdose

When using Medication Nazo-Spray for more than one week in a row, as well as accidental ingestion of the medication, there may be signs of overdose:

• spasms of peripheral vessels;
• enlargement or narrowing of the pupil;
• attacks of nausea and vomiting;
• heart rhythm disorders;
• insufficiency of cardiac activity;
• a collaptoid state;
• hyperhidrosis;
• pulmonary edema, respiratory function disorders;
• blanching of the skin;
• convulsions, nervous disorders, strong emotional arousal.

Sometimes an overdose is characterized by a violation of the central nervous system, which is manifested by fatigue, drowsiness, a drop in blood pressure, the development of a coma.

If the product is swallowed, it is recommended to wash the stomach, take sorbent preparations (activated charcoal, sorbex, etc.).

[18], [19], [20]

Interactions with other drugs

With the combined use of other drugs that can narrow the blood vessels, there may be an increase in side effects.

The active ingredient worsens the absorption of other nasal solutions and lengthens the period of their action, and also enhances the effect on the nervous system of MAO inhibitory agents.

It is not recommended to use Nazo-Spray for a long time, since this can provoke the development of atrophic changes in the mucosal epithelial tissue. For the same reasons, several vasoconstrictors should not be used simultaneously.

Treatment of chronic forms of rhinitis should be conducted alternately, in conjunction with other means.

Storage conditions

Nazo-spray should be stored in dark places (for example, in a closet), away from children's access places. The optimum temperature regime for the preservation of the drug is up to + 25 ° C.

[21], [22],

Shelf life

Shelf life Naso spray - up to 2 years.

[23], [24]