Nasivin

The medicinal drug Nazivin is intended for intranasal external use, for the treatment of rhinitis and rhinorrhea of various etiologies. According to the ATX classifier, Nazivin is assigned the code R01AA05.

Indications Nasivin

Nazivin can be prescribed for the treatment of rhinorrhea of various origins:

• nasal discharge accompanying acute respiratory viral infection or acute respiratory disease;
• vasomotor rhinitis;
• allergic rhinitis;
• swelling of the nasal cavity, sinusitis or sinusitis.

In addition, Nazivin can be used to prepare for diagnostic procedures or operations in the nasal cavity.

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Release form

Intranasal drops Nazivin are available in glass bottles with a dosing pipette, 10 ml of 0.025% and 0.05% of the drug, or 5 ml of 0.01% of the drug. The drops look like a transparent, sometimes slightly yellowish solution. Each bottle is packed in a separate cardboard box.

A more convenient version of the drug Nazivin Sensitive is also available in the form of a metered-dose spray containing 0.250 mg of oxymetazoline.

10 g of drops contain:

• oxymetazoline hydrochloride – 0.1 mg, 0.25 mg or 0.5 mg;
• additional components (benzalkonium chloride, sodium dihydrogen phosphate, sodium hydroxide, etc.).

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Pharmacodynamics

Nazivin spray has an external vasoconstrictor effect. The active ingredient oxymetazoline is a synthetic adrenergic agonist that activates adrenergic receptors located in the smooth muscles of the vascular network of the nasal cavity.

Nazivin stops rhinorrhea of any origin. The active substance oxymetazoline quickly narrows superficial vessels, reduces signs of swelling of mucous tissues, facilitates breathing through the nose and restores the sense of smell.

Pharmacokinetics

Oxymetazoline begins to act immediately after application of the drug to the mucous membranes. The duration of the vasoconstrictive effect is up to 10 - 12 hours.

Systemic absorption of the active component is insignificant. Excretion occurs through the kidneys (more than 2%) and intestines (more than 1%). Half-life is about 35 hours.

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Dosing and administration

Nazivin drops are used according to the following schemes:

• adults and children over six years of age administer 1-2 drops of 0.05% Nazivin up to 3 times a day;
• children aged 1-6 years are given 1-2 drops of 0.025% Nazivin up to 3 times a day;
• Children under 12 months of age are given 1 drop of 0.01% preparation up to 3 times a day.

Nazivin Sensitive spray is intended for intranasal administration, which is carried out as follows:

• children from 1 to 6 years old use one injection of the drug 11.25 mcg/dose up to 3 times a day;
• Children over 6 years of age use one injection of the drug 22.5 mcg/dose up to 3 times a day.

The frequency of use of the drug is once every 8-12 hours. The duration of the treatment course is 4-7 days.

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Use Nasivin during pregnancy

The use of Nazivin during pregnancy is not recommended. Sometimes the drug can be prescribed only after a thorough assessment of the probable risks to the course of pregnancy and fetal development. In this case, you should especially carefully adhere to the recommended doses of the drug.

During lactation, it is forbidden to use products based on oxymetazoline.

Contraindications

• Hypersensitivity to oxymetazoline, tendency to allergic reactions to other components of Nazivin.
• Pathologies associated with metabolic disorders (thyroid disease, diabetes mellitus).
• Increased intraocular pressure.
• Atrophy of the mucous membranes of the upper respiratory tract.
• Concomitant treatment with MAO inhibitors or other drugs that increase blood pressure.
• Myocardial ischemia, hypertension, cardiac failure.
• Pronounced atherosclerotic vascular changes.
• Heart rhythm disturbances.
• Pheochromocytoma.
• Prostatic hyperplasia.

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Side effects Nasivin

With prolonged use of Nazivin, the following side effects may develop:

• pain, itching and burning in the nasal cavity;
• drying of the nasal mucosa;
• nasal congestion, drug-induced rhinitis;
• tachycardia, increased blood pressure, heart pain;
• allergic reactions (rash, urticaria, angioedema);
• allergic conjunctivitis;
• nausea not associated with food intake;
• atrophic changes in the mucous membrane, frequent nosebleeds;
• poor sleep, irritability;
• feeling tired, headache.

To avoid side effects, it is not recommended to use oxymetazoline for a long time, or to exceed the recommended doses. After the end of treatment, the damaged structure of the mucous membrane is restored in most cases.

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Overdose

When using Nazivin for more than one week in a row, as well as in case of accidental ingestion of the drug, the following signs of overdose may be observed:

• dilation of pupils;
• dyspeptic disorders;
• deterioration of blood supply to the extremities;
• peripheral vascular spasms;
• heart rhythm disorders;
• cardiac insufficiency;
• collapse;
• increased sweating;
• pulmonary edema, respiratory dysfunction;
• paleness of the skin;
• convulsions, nervous disorders.

Often, an overdose is accompanied by a disruption of the central nervous system, which manifests itself as fatigue, drowsiness, a drop in blood pressure, and a comatose state.

If the drug is swallowed, it is recommended to wash the stomach and take sorbent drugs. In severe cases, symptomatic treatment is carried out.

Interactions with other drugs

When combined with other drugs that can constrict blood vessels, increased side effects may be observed.

Oxymetazoline blocks the absorption of other nasal drops and prolongs their period of action, and also enhances the effect of MAO inhibitor drugs on the central nervous system.

Long-term use of Nazivin is not recommended, as it may provoke the development of atrophic changes in the mucous epithelium. For the same reasons, several vasoconstrictors of local action should not be used simultaneously.

For the treatment of chronic forms of rhinitis, Nazivin is prescribed in combination with other drugs, depending on the cause of the runny nose.

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Storage conditions

Nazivin should preferably be stored in dark places, away from children's reach. The optimal temperature range for preserving the medicine is from +20°C to +25°C.

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Shelf life

The shelf life of Nazivin drops and Nazivin Sensitive nasal spray is up to 3 years.

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