Nase gel

Nayz-gel is used for local symptomatic therapy of diseases of the musculoskeletal system of an inflammatory and degenerative nature.

Indications Nase gel

Nayz-gel is used for local symptomatic therapy of diseases of the musculoskeletal system of an inflammatory and degenerative nature. These diseases include articular syndromes with exacerbations of gout, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteochondrosis with radicular syndrome, radiculitis, inflammatory lesions of ligaments and tendons, bursitis, sciatica and lumbago. Also, the drug is indicated for muscle pains that are caused by rheumatic or non-rheumatic causes. The use of medication is indicated in post-traumatic inflammations of soft tissues and the musculoskeletal system - with injuries and ruptures of ligaments, as well as bruises.

[1]

Release form

Naise gel is produced in the form of a transparent gel that does not contain foreign particles, which has a light yellow or yellowish color. The drug is packaged in tubes of laminated aluminum for twenty or fifty grams each. Tubes protect the membrane that controls the first autopsy. Each tube is packed in cardboard packaging and is supplied with an insert-instruction.

One gram of the gel contains ten milligrams of nimesulide, and there are also auxiliary substances: N-methyl-2-pyrrolidone, propylene glycol, macrogol, isopropanol, purified water, carbomer 940, butylhydroxyanisole, thiomersal, potassium dihydrogen phosphate, flavor.

[2]

Pharmacodynamics

Nyz-gel has a local anesthetic and anti-inflammatory effect. The active component of the drug, nimesulide, is a selective competitive reversible cyclooxygenase 2 inhibitor. The substance is able to reduce the content of certain prostaglandins that are present in the foci of inflammatory processes, as well as in the pathways of pain impulses in the spinal cord. All this leads to the appearance of analgesic and anti-inflammatory effects.

[3], [4], [5], [6], [7], [8]

Pharmacokinetics

Local application of Nase gel causes a low absorption of active substances, which leads to very low concentrations of the components of the drug in the circulatory system. The maximum amount of active substance after one-time use of the gel is observed after about twenty-four hours. The concentration of nimesulide in this form of its use is three hundred times lower than when using its oral forms. In the blood, the main metabolite of the active substance, 4-hydroxynimidesulide, is not found.

[9], [10], [11]

Dosing and administration

Naise gel is used externally. The drug is applied to the washed and dried surface of the skin. It is necessary to distribute evenly and thinly over the affected surface the amount of medicine in three centimeters, which do not need to be rubbed into the skin. This procedure should be done three or four times a day. The course of treatment can not be more than ten days.

[14], [15], [16], [17], [18], [19]

Use Nase gel during pregnancy

The drug Nayz-gel is contraindicated to use during pregnancy and lactation period.

Contraindications

• Presence of hypersensitivity to the active substance and auxiliary components of the drug.
• There are erosions or ulcers of the gastrointestinal tract, which are in an aggravated stage.
• The presence of bleeding from the gastrointestinal tract.
• The presence of dermatoses, damage to the epidermis and infections of the skin in the place where it is necessary to use the drug.
• Presence in the anamnesis of the patient expressed renal or hepatic insufficiency.
• A history of bronchospasm, which is caused by the use of acetylsalicylic acid or other nonsteroidal anti-inflammatory drugs.
• The patient's age is up to seven years.
• Cautiously used for severe heart failure, hypertension, diabetes mellitus type 2, as well as in the elderly and childhood to twelve.

[12]

Side effects Nase gel

• Allergic reactions - the appearance of itching, hives, skin flaking and transient changes in its color.
• With prolonged use of the drug and when it is applied to large areas of the skin, systemic side reactions are sometimes observed. These include symptoms of heartburn, nausea, vomiting, diarrhea, gastralgia, ulceration of the gastrointestinal tract, increased activity of liver enzymes. There are also signs of headaches, dizziness, fluid retention, hematuria, allergic reactions - skin rash, anaphylactic shock, thrombocytopenia, leukopenia, anemia, agranulocytosis, increased bleeding time.

[13],

Overdose

There are no described cases of drug overdose Naise-gel. Although if the surface of the skin is applied more than fifty grams of medicament, there may be signs of an overdose. At present, there is no specific antidote, therefore in such cases it is necessary to urgently contact specialists.

Interactions with other drugs

Possible interaction of pharmacokinetic character with drugs that compete for binding to serum proteins. It is necessary to use with caution the Nase-gel and simultaneously digoxin, phenytoin, lithium preparations, diuretics, cyclosporins, methotrexate, and other non-steroidal anti-inflammatory drugs. The same applies to antihypertensive and antidiabetic medications.

[20], [21], [22], [23], [24], [25]

Storage conditions

Naize-gel - the drug should not be frozen; Keep in a dark place, which is not accessible to children of children at an ambient temperature of up to 25 ° C.

[26]

Shelf life

Naize-gel is stored for 2 years from the date of issue.

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