Nyz-gel

Nise gel is used for local symptomatic therapy of inflammatory and degenerative diseases of the musculoskeletal system.

Indications Nyz-gel

Nise-gel is used for local symptomatic therapy of inflammatory and degenerative diseases of the musculoskeletal system. These diseases include joint syndromes during exacerbations of gout, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthrosis, osteochondrosis with radicular syndrome, radiculitis, inflammatory lesions of ligaments and tendons, bursitis, sciatica and lumbago. The drug is also indicated for muscle pain caused by rheumatic or non-rheumatic reasons. The use of the drug is indicated for post-traumatic inflammation of soft tissues and the musculoskeletal system - with damage and ruptures of ligaments, as well as bruises.

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Release form

Nise-gel is produced as a transparent gel, free of foreign particles, which has a light yellow or yellowish color. The medicine is packaged in laminated aluminum tubes of twenty or fifty grams each. The tubes are protected by a membrane that controls the first opening. Each tube is packed in a cardboard package and supplied with an instruction leaflet.

One gram of gel contains ten milligrams of nimesulide, and also contains excipients: N-methyl-2-pyrrolidone, propylene glycol, macrogol, isopropanol, purified water, carbomer 940, butylhydroxyanisole, thiomersal, potassium dihydrogen phosphate, flavoring agent.

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Pharmacodynamics

The drug Nise-gel has a local anesthetic and anti-inflammatory effect. The active component of the drug - nimesulide - is a selective competitive reversible inhibitor of cyclooxygenase 2. The substance is able to reduce the content of some prostaglandins, which are present in the foci of inflammatory processes, as well as in the pathways that conduct pain impulses in the spinal cord. All this leads to the appearance of analgesic and anti-inflammatory effects.

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Pharmacokinetics

Local application of Nise-gel causes low absorption of active substances, which leads to very low concentrations of the components of the drug in the circulatory system. The maximum amount of the active substance after a single use of the gel is observed approximately twenty-four hours later. The concentration of nimesulide in this form of its application is three hundred times lower than when using its oral forms. The main metabolite of the active substance, 4-hydroxynimesulide, is not detected in the blood.

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Dosing and administration

Nise gel is used externally. The medicine is applied to the washed and dried skin surface. It is necessary to evenly and thinly distribute the amount of medicine over the affected surface in three centimeters, which do not need to be rubbed into the skin. This procedure should be done three or four times a day. The course of treatment cannot be more than ten days.

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Use Nyz-gel during pregnancy

The drug Nise-gel is contraindicated for use during pregnancy and lactation.

Contraindications

• The presence of hypersensitivity to the active substance and auxiliary components of the drug.
• Existing erosions or ulcers of the gastrointestinal tract that are in an acute stage.
• Presence of bleeding from the gastrointestinal tract.
• The presence of dermatoses, damage to the epidermis and skin infections in the area where the drug should be used.
• The patient has a history of severe renal or hepatic insufficiency.
• History of bronchospasm caused by use of aspirin or other nonsteroidal anti-inflammatory drugs.
• The patient's age is under seven years.
• Use with caution in cases of severe heart failure, arterial hypertension, type 2 diabetes, as well as in the elderly and children under twelve years of age.

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Side effects Nyz-gel

• Allergic reactions – the appearance of itching, hives, peeling of the skin and transient changes in its color.
• With prolonged use of the drug and when applied to large areas of the skin, systemic side effects are sometimes observed. These include symptoms of heartburn, nausea, vomiting, diarrhea, gastralgia, ulceration of the gastrointestinal tract, increased activity of liver enzymes. Signs of headaches, dizziness, fluid retention, hematuria, allergic reactions - skin rash, anaphylactic shock, thrombocytopenia, leukopenia, anemia, agranulocytosis, increased bleeding time also occur.

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Overdose

There are no described cases of overdose with Nise-gel. Although if more than fifty grams of the drug is applied to the skin surface, signs of overdose may appear. Currently, there is no specific antidote, so in such cases it is necessary to urgently contact specialists.

Interactions with other drugs

Pharmacokinetic interactions with medications that compete for binding to serum proteins are possible. It is necessary to use Nise-gel with caution and simultaneously digoxin, phenytoin, lithium preparations, diuretics, cyclosporines, methotrexate, and other non-steroidal anti-inflammatory drugs. The same applies to antihypertensive and antidiabetic medications.

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Storage conditions

Nise-gel - the drug must not be frozen; store in a dark place, out of reach of children, at an ambient temperature of up to 25C°.

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Shelf life

Nise gel has a shelf life of 2 years from the date of manufacture.

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