Mexicor

Mexicor is a member of the cardiologic medication subgroup.

[1], [2], [3]

Indications Mexicor

It is used for the combined treatment:

• acute degree of myocardial infarction (starting from the 1st day);
• ischemic stroke ;
• DCE (this includes disorders with atherosclerotic etiology);
• moderate and light stages of cognitive impairment of diverse origin.

[4], [5],

Release form

The release of the pharmaceutical substance is implemented in the injection fluid, 2 ml inside the ampoule. The plate contains 5 ampoules, in a box - 2 such plates.

Pharmacodynamics

The mexicor helps to improve the activity of ischemic myocardium in the event of a heart attack, and at the same time improves the contractile activity of the heart and alleviates the symptoms of diastolic and systolic left ventricular dysfunction.

The influence of the drug is based on its antioxidant effect and the ability to slow down the activity of free radicals (they are intensified in case of necrosis or myocardial ischemia, especially during reperfusion), and also to reduce the damaging effect of free radicals on cardiomyocytes.

With a critical weakening of the coronary blood flow, the drug helps to maintain the functioning and structure of the walls of cardiomyocytes and stimulates the activity of membrane enzymes - AC, PDE and AChE.

The drug potentiates the activation of glycolysis of aerobes, which occurs in the case of the acute stage of ischemia, and also helps restore the processes of oxidation-reduction within the mitochondria and potentiates the binding of phosphocreatine and ATP. These mechanisms help to ensure the integrity of the morphological ligaments and the physiological activity of myocardial ischemia.

The substance stabilizes the metabolic processes within the myocardium affected by ischemia, reduces the area of necrosis, improves or restores contractility and electrical effect of the myocardium, and at the same time potentiates the coronary circulation in the ischemic area and increases the antianginal effect of nitrosodermal drugs. In addition, it improves the rheological blood parameters and weakens the effects of the reperfusion syndrome developing under the influence of coronary insufficiency (acute nature).

The drug has neuroprotective properties, stabilizes cerebral blood flow during hyperperfusion and improves cerebral blood flow during the reperfusion phase after ischemia.

The drug helps to adapt to the damaging ischemic effects, slows post-ischemic weakening of glucose and oxygen utilization through the brain and prevents the progressive cumulation of lactate.

The substance improves and normalizes the metabolic processes inside the brain, as well as the cerebral blood supply, and with it contributes to the support of the brain during ischemia and during the post-ischemic phase.

The drug has anxiolytic selective activity in which no muscle relaxation and sedation are observed; The Mexicor relieves fear, anxiety, anxiety and mental stress.

The drug has nootropic properties, prevents and reduces problems with the ability to memorize and learn, which appear with lesions of the cerebral vessels or cognitive disorders with a moderate or mild degree. It also has an antihypoxic effect and increases efficiency with concentration.

When using the medication in the combined treatment of people with acute stages of cerebral blood flow disorders, the severity of clinical signs weakens and the course of rehabilitation improves.

[6], [7], [8], [9], [10], [11]

Pharmacokinetics

After intravenous injection of the drug, it penetrates into tissues with organs at high speed (within a 30-90 minute period), due to which its blood indices in an unchanged state decrease rapidly. After the use of therapeutic portions of drugs, plasma level Cmax is noted after 30-40 minutes and is equal to 2.5-3 mg / ml; metabolic elements are recorded inside the blood plasma after 7-9 hours. Intrahepatic metabolic processes are developed by glucuronidation.

Excretion is carried out together with the urine (glucuronidine state). In an unchanged state, only a small part of the substance is removed.

[12], [13], [14], [15], [16], [17]

Dosing and administration

The Mexicor is administered over a 2-week period in a / m or intravenous route, in combination with standard treatment of myocardial infarction.

During the first 5 days, to obtain the maximum therapeutic effect, it is recommended to use the drug intravenously, and then (9-day period) it is used intramuscularly.

The substance is administered intravenously via an IV drip - using an infusion, at low speed (to prevent the development of side effects), with the addition of 0.1-0.15 liters of 0.9% NaCl or 5% glucose fluid (procedure 0, lasts 5-1.5 hours). If required, low speed jetting may be used, lasting at least 5 minutes.

The drug is used in / in or in the / m way, 3 times a day, with 8-hour intervals between procedures.

During the day, it is required to administer 6–9 mg / kg of the drug, and for 1 injection, 2–3 mg / kg. During the day, no more than 0.8 g of the drug can be administered, and a maximum of 0.25 g at a time.

In the case of acute intracerebral blood flow disorder (in the ischemic form of a stroke), the drug is used in combination with other drugs — in the first 2-4 days it is administered via an IV drip (2-3 times a day, at 0.2-0.3 g) and later intramuscularly (0.1 g 3 times a day). The duration of this cycle is 10-14 days. Later, the medication is used in capsules - 0.1 g 2 times a day for a 14-day cycle, and then 0.1 g 3 times daily for a 7-day course. The duration and frequency of repeated cycles is selected by the doctor, taking into account the course of the disease.

With decompensated DCE, the drug is administered through an intravenous drip, intravenously in a dose of 0.1 g, 2-3 times per day within a 14-day cycle, and then it is taken in capsules, 2-4 times a day, at 0.1 g The prophylactic course consists of intramuscular injections of 0.1 g of the drug 2 times a day for a period of 10-14 days.

During the treatment of cognitive impairment with a mild or moderate stage, Mexicor is used in the i / m method, in a dose of 0.1-0.3 g per day, over a 2-week term; then, if necessary, take capsules - 0.1 g of drug 2-4 times per day. The duration and mode of use of the drug is selected by the doctor, taking into account the course of the pathology.

[24], [25], [26], [27]

Use Mexicor during pregnancy

Do not use the Mexicor during pregnancy or breastfeeding.

Contraindications

It is contraindicated for people with kidney or liver failure, as well as with intolerance associated with the elements of drugs.

[18], [19], [20], [21], [22]

Side effects Mexicor

After the IV injection, especially the jet, there may be a metallic taste or dry oral mucosa, an unpleasant smell and a feeling of heat throughout the body. It is also possible a feeling of discomfort in the sternum, tickling inside the throat, as well as palpitations, dyspnea, a short increase or decrease in blood pressure, tremor, tachycardia with headaches, distal form of hyperhidrosis and facial hyperemia. Typically, these symptoms occur because of a too high rate of drug administration and short-lived.

With prolonged use of the medication, the following side effects may develop:

• lesions affecting the gastrointestinal tract: diarrhea, bloating, nausea and dyspeptic disorders;
• Disorders associated with the work of the central nervous system: sleep problems (sleep disorders or severe drowsiness), anxiety or weakness, dizziness, coordination disorder, emotional reactivity and peripheral edema.

With personal intolerance to medication, there may be signs of allergies, including itching, rash, bronchial spasm and angioedema.

[23]

Overdose

Intoxication can lead to insomnia, and sometimes vice versa - feelings of drowsiness. Intravenous injections can provoke a weak and short-term increase in blood pressure.

When signs of poisoning appear, they usually use a stopping drug. The described sleep disorders pass by themselves throughout the day. In extremely difficult situations, you should take a sleeping pill and anxiolytic (10 mg of oxazepam with nitrazepam and 5 mg of diazepam).

With a significant increase in blood pressure indicators, antihypertensive drugs are used, controlling these indicators, or supplement treatment with nitro-containing substances.

Interactions with other drugs

The drug potentiates the effects of anxiolytics from the benzodiazepine group, anti-parkinsonian elements (levodopa) and anticonvulsants (carbamazepine). Mexicor also enhances the effects of antihypertensive drugs and nitro-containing components.

Weakens the toxic properties of ethyl alcohol.

[28], [29], [30]

Storage conditions

The mexicor should be kept out of the reach of small children, in a dark place. Temperature marks - not higher than 25 ° C.

[31], [32], [33]

Shelf life

A mexicor can be applied for a 36-month term from the time the drug was manufactured.

[34], [35], [36], [37]

Application for children

The drug is not prescribed in pediatrics (up to the 18th anniversary), because there is no data on the possibility of its safe and effective use in this age group.

Analogs

Analogues of the drug are the drugs Nuxlex, Neocardil, Thiotriazolin with T-Triomax, and Metapril with Tivortin Aspartate.

[38], [39]