Memozam

Memozam belongs to the subgroup of nootropic substances and psychostimulants. It is a complex medicine. Its active elements are piracetam (a cyclic derivative of γ-aminobutyric acid), as well as cinnarizine (a selective antagonist of Ca channels).

The drug improves the conductivity within the synapses of the neocortical structures, as well as the connection between the cerebral hemispheres. With prolonged administration of drugs, people with weakened brain activity improve attention and cognitive abilities. [1]

Indications Memozam

It is used as a supportive agent for disorders of a cerebrovascular nature, including disorders of mental function and memory, mood disorders (a feeling of irritability) and deterioration in concentration.

It is prescribed as a supportive agent for manifestations of labyrinthine disorders, including ear noise, vomiting, dizziness, nausea and nystagmus.

It is also used in the case of Meniere's syndrome , and in addition to prevent the development of migraines and kinetosis.

Release form

The release of the substance is realized in capsules - 10 pieces inside a cell package; in a box - 3 or 6 such packages.

Pharmacodynamics

It is likely that Memozam has several mechanisms of drug action:

• correction of the speed of movement of excitation impulses inside the brain;
• potentiation of metabolic processes inside neuronal cells;
• improving the processes of microcirculation by influencing the rheological blood properties, without the development of a vasodilating effect.

Piracetam is a brain-targeting nootropic. Helps improve cognitive performance (memory, learning, attention) and intellectual performance. [2]

Cinnarizine inhibits the contraction of vascular smooth muscle cells by blocking the activity of Ca channels. In addition to direct antagonism with respect to Ca, cinnarizine reduces the contractile function of vasoactive elements (serotonin with norepinephrine) by blocking the endings of Ca channels that they control. The severity of the blockade of cellular Ca uptake is determined by the type of tissue. As a result, an anti-vasoconstrictor effect develops without affecting the level of heart rate and blood pressure. [3]

Further, cinnarizine is able to improve weak microcirculation by increasing the elasticity of the erythrocyte wall and decreasing blood viscosity. There is also an increase in the resistance of cells to hypoxia.

Cinnarizine inhibits the processes of stimulating the activity of the vestibular system, which suppresses the development of nystagmus and other autonomous disorders. Along with this, cinnarizine prevents the development of severe dizziness.

Dosing and administration

Capsules must be taken orally, after a meal - washed down with plain water and swallowed without chewing.

In case of disorders of intracerebral blood flow and balance disorders, take 3 times a day for the 1st capsule of the drug.

In case of kinetosis, take 1 capsule 30 minutes before the walk. Reception must be repeated at 6-hour intervals.

• Application for children

It is forbidden to prescribe medicine in pediatrics.

Use Memozam during pregnancy

You can not use Memozam with hepatitis B or pregnancy.

Piracetam can be excreted in breast milk, which is why, if you need to use drugs, you need to stop breastfeeding.

Contraindications

The main contraindications:

• severe intolerance to cinnarizine with piracetam, as well as other auxiliary elements of the medication;
• failure of the kidneys in a severe stage;
• active phase of cerebral blood flow disorder (hemorrhagic stroke);
• Huntington's syndrome;
• parkinsonism;
• an increase in IOP indicators;
• excitement of a psychomotor nature.

Side effects Memozam

Among the side effects:

• disturbances in the activity of the NS: insomnia, hyperkinesia, headaches and ataxia; in addition, the likelihood of worsening epilepsy, tremor, dyskinesia, vestibular disturbances, hypersomnia, fatigue, balance disorder, lethargy, parkinsonism and an increase in the frequency of epileptic seizures may be noted. Prolonged administration to the elderly can provoke extrapyramidal symptoms;
• immune lesions: severe intolerance, including anaphylaxis;
• disorders associated with the digestive system: dyspepsia, diarrhea, xerostomia, vomiting, abdominal pain, nausea, cholestatic jaundice and hypersalivation;
• epidermal disorders: rashes, hyperhidrosis, LP and SLE, Quincke's edema, pruritus, photosensitivity, urticaria, dermatitis and lichen-like keratosis;
• mental problems: anxiety, increased excitability, confusion, drowsiness, hallucinations and depression;
• lesions of the musculoskeletal structure: muscular rigidity;
• symptoms associated with the labyrinth and auditory organs: dizziness appears singly;
• violations of reproductive function and work of the mammary glands: libido increases singly;
• others: thrombophlebitis, asthenia, hyperthermia and increased blood pressure values. Prolonged administration of the medication can occasionally lead to weight gain.

Overdose

Poisoning causes a potentiation of the side symptoms of the drug. Occasionally, with acute intoxication, signs of dyspepsia develop (pain in the abdomen and bloody diarrhea), vomiting, changes in consciousness (from drowsiness to stupor and coma), extrapyramidal signs and a decrease in blood pressure. In a child, an overdose usually causes symptoms of agitation - anxiety, tremors, euphoria, insomnia, and irritability; occasionally there are seizures, nightmares and hallucinations.

Memozam has no antidote. In the period of the first 60 minutes from the moment of using the drug, gastric lavage should be performed. If necessary, the intake of activated carbon is prescribed. Symptomatic actions are also performed. Hemodialysis can be performed.

Interactions with other drugs

The introduction of the drug with alcoholic beverages, tricyclics or substances that suppress the function of the central nervous system, causes a potentiation of the sedative effect.

The medication enhances the therapeutic activity of antihypertensive drugs and vasodilators, as well as nootropic substances.

The effect of Memozam is potentiated when used together with vasodilating agents; cinnarizine weakens the effects of antihypertensive drugs.

The drug potentiates the effect of thyroid hormones, which can cause the development of anxiety and tremors.

The drug potentiates the effect of oral anticoagulants.

Due to the antihistaminic activity of the drug, a positive reaction to the factors of epidermal reactivity may be masked during the skin test. Because of this, it is necessary to cancel the drug intake 4 days before the test.

Storage conditions

Memoses should be kept out of the reach of small children. Temperature indicators are not higher than the 30 ° C mark.

Shelf life

Memozam can be used within 24 months from the date of sale of the medicinal product.

Analogs

The analogs of the drug are the substances Olatropil, Evrizam with Neuro-norm, Phezam and Noozam, and in addition, Thiocetam with Cinatropil and Omaron.