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M-kam
Last reviewed: 23.04.2024
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Indications M-kam
Indications for use M-kam include painful pathology and inflammation of the joints:
- arthritis,
- rheumatoid arthritis,
- osteoarthritis,
- polyarthritis,
- arthrosis,
- osteoarthritis,
- ankylosing spondylitis (Bechterew's disease),
- as well as pain caused by trauma.
[3]
Release form
The form of this medication is oral tablets in a dosage of 7.5 and 15 mg.
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Pharmacodynamics
Pharmacodynamics M-kam does not differ from the mechanism of action of most non-steroidal anti-inflammatory drugs. The therapeutic effect is the selective inhibition of the enzyme cyclooxygenase (COX) involved in the formation of prostaglandins - mediators of the inflammatory reaction. It is the accumulation of excess prostaglandins that causes local symptoms of inflammatory processes.
The active substance of this preparation (4-hydroxy-2-methyl-N- (5-methyl-2-thiazolyl) -2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide or meloxicam) promotes a decrease in oxidation activity and other biochemical reactions in cells affected by inflammation. As a result, the permeability of cell membranes is reduced, which prevents the spread of the pathological process. In parallel, there is a significant slowdown in the release of histamine and serotonin, which play an important role in the development of any inflammatory processes in the body.
In addition, meloxicam in the M-cap inhibits the adhesion (aggregation) of platelets, which prevents blood clotting in the capillaries and worsening of microcirculation in the area of inflammation.
[5]
Pharmacokinetics
M-kam, getting into the stomach, is well absorbed into the blood from the gastrointestinal tract. The maximum concentration in blood plasma is reached in 5-6 hours, the degree of bioavailability of M-kam is 89%.
99.4% of the active substance binds to plasma albumin. The drug penetrates the blood-brain barrier and enters the synovial fluid filling the joint cavity, the content of the synovial fluid 2.5 times higher than in the blood plasma.
M-kam, like all NSAIDs of the group of oxycomas, is a long-acting drug. The drug is metabolized in the liver, where it splits and the formation of metabolites. The cleavage products from the body are excreted by the kidneys and in an insignificant measure by the intestine; half of the metabolites are excreted after about 15-20 hours.
Use M-kam during pregnancy
The use of M-kam during pregnancy is considered inadmissible due to the increased threat of teratogenic effects of this drug on the embryo and fetus (the occurrence of defects in the cardiac septum).
Contraindications
The following contraindications for the use of M-kam are noted: hypersensitivity to NSAIDs, non-perception of acetylsalicylic acid (which is expressed in an allergic reaction called the "aspirin triad"), gastric and duodenal ulcers (in the acute phase), bleeding of any etiology and localization, severe form cardiac, renal and hepatic insufficiency, pregnancy, lactation, children's age (up to 14 years).
Side effects M-kam
The most common side effects of M-kam are: urticaria, drowsiness, headache, tinnitus, swelling of the soft tissues of the extremities, increased blood pressure and heart rate, changes in blood composition (leukopenia or thrombocytopenia), nausea, vomiting, pain in the abdominal area, stool disorders. Reception of M-kama is often accompanied by inflammation of the oral mucosa (stomatitis) or eyes (conjunctivitis), disruption of the kidneys (up to the nephrotic syndrome and glomerulonephritis) and an increase in urea in the urine.
Severe adverse side effects of this drug may manifest as angioedema and anaphylactic shock.
Overdose
Overdosing of the drug leads to a significant increase in the manifestation of its side effects. In case of overdose, it is necessary to take activated charcoal.
[14]
Interactions with other drugs
Interactions of M-kam with other drugs consist in reducing the therapeutic effect of drugs for the treatment of arterial hypertension and cardiovascular insufficiency, beta-blockers and ACE inhibitors, as well as blocking the action of diuretics and some antibacterial drugs (a group of fluoroquinolones).
You can not prescribe M-kam along with anticoagulant drugs, salicylates and other non-steroidal anti-inflammatory drugs.
Shelf life
Shelf life of the drug is 3 years from the date of release.
[21]
Attention!
To simplify the perception of information, this instruction for use of the drug "M-kam" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.