Indovenol

Indovenol is a capillary stabilizing drug from the category of angioprotectors.

Indications Indovenol

It is used locally for the following disorders:

• trophic disorders arising against the background of chronic venous insufficiency;
• varicose veins, which cause swelling and pain;
• diseases affecting joints and muscles (tendonitis with bursitis, as well as synovitis and myositis);
• hematomas of traumatic origin.

Release form

The drug is released in the form of a gel, in tubes of 40 g.

Pharmacodynamics

The therapeutic effect of the drug is due to the activity exerted by the active ingredients that are part of its composition - venorutinol with indomethacin.

Venorutinol is a bioflavonoid and has a P-vitamin effect. It has a strong venotonic, anti-edematous, angioprotective, as well as antioxidant and anti-inflammatory effect, strengthens capillaries, increasing their strength and preventing fragility, promotes their elasticity and flexibility, as well as resistance to injury. At the same time, the element weakens exudative inflammation inside membranes. All this allows to stabilize microcirculation, improve tissue trophism, and reduce congestive reactions inside veins and perivenous tissues.

Indomethacin belongs to the category of NSAIDs, with local treatment providing a strong analgesic, anti-inflammatory, antiplatelet and anti-edematous effect, which are caused by the suppression of the processes of binding of PG and other inflammatory mediators.

Because the medicine is made on a gel base, it is released at high speed and completely inside the body, creating the required medicinal concentrations inside the synovium and inflamed tissues.

Pharmacokinetics

Indomethacin undergoes protein synthesis in the blood plasma; this figure is 90%. Metabolic processes occur in the liver – O-demethylation and N-deacetylation of the substance to inactive components occur.

Excretion of 60% of the drug occurs with urine, and another 30% is excreted with feces. The drug enters breast milk.

Dosing and administration

Indovenol should be used externally only. 500-1000 mg of the substance (a gel strip about 2.5-5 cm long) should be applied evenly to the epidermis, rubbing in a little for 1-2 minutes. After applying, wash your hands thoroughly (except for situations where applications are performed on the hands). This process should be repeated 2-3 times a day. In general, no more than 5000 mg of the drug can be used per day.

The duration of the therapy cycle is selected by the doctor, taking into account the nature of the pathology. In general, the course can last no more than 10 days.

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Use Indovenol during pregnancy

Indovenol should not be administered to nursing mothers or pregnant women.

Contraindications

Among the contraindications:

• the presence of strong sensitivity to indomethacin, other NSAIDs, as well as venorutinol or other components of the drug;
• the presence of intolerance to aspirin or other NSAIDs, which manifests itself in the form of an asthma attack, allergic rhinitis or urticaria.

Side effects Indovenol

Sometimes after using the gel, local symptoms of intolerance (allergy signs) develop, including itching, Quincke's edema, hyperemia, skin irritation, local swelling and eczema, as well as urticaria, dermatitis (including the contact form) and rashes (also vesicular). In addition, a burning sensation or heat in the treatment area, peeling and dry skin. Small blisters and pustules or blisters may also appear on the skin.

Occasionally, with prolonged use on large areas of the epidermis, systemic side effects occur:

• digestive disorders: stomach pain, nausea, ulcers, diarrhea, bleeding, vomiting, loss of appetite and increased liver enzyme levels;
• problems with urinary activity: urinary disorder, swelling, change in the smell or color of urine and hematuria;
• CNS disorders: headaches, confusion, memory problems, dizziness, depression, speech disorders, and problems with vision or hearing;
• immune system disorders: angioedema, allergic rhinitis, anaphylaxis, asthma attack and suffocation;
• Others: myalgia, redness of the eyes or dryness of the ocular mucosa, weakness in the muscle area, increased blood pressure, jaundice and changes in laboratory data regarding the composition of peripheral blood.

The drug contains propylene glycol and dimethyl sulfoxide, which can cause skin irritation. Such manifestations disappear on their own after stopping the use of the drug.

If any negative symptoms appear, you should consult your doctor regarding the advisability of further use of the gel.

Overdose

There have been no cases of overdose. However, given the probable prolonged use in doses exceeding the optimal ones, the possibility of treating large areas of the epidermis and the combined use of indomethacin with other drugs, there is a risk of negative symptoms. If they appear, it is necessary to wash off or remove the remaining gel from the epidermis. Also, if necessary, symptomatic measures are carried out.

Long-term use (longer than 10 days) requires patient monitoring to determine possible systemic reactions: severe headaches, hepatotoxicity, hemorrhages and laboratory blood tests (monitoring platelet levels and white blood cell count).

After unintentional oral administration of the drug, a burning sensation in the oral mucosa, nausea, salivation and vomiting are observed. In such cases, it is necessary to rinse the oral cavity and stomach, and also carry out symptomatic procedures, if necessary.

If the gel gets on open wounds, mucous membranes or in the eyes, local irritation develops - redness, pain and a burning sensation, as well as lacrimation. In such situations, the affected areas are washed with a 0.9% NaCl solution or distilled water - until the irritation stops or decreases.

Interactions with other drugs

When using the drug, the likelihood of interaction with other medications is extremely low. NSAIDs can affect drugs that lower blood pressure, but with local application of the substance, such a possibility is very unlikely. At the same time, the risk of developing an effect in the future cannot be ruled out if the drug is used for a long time in excessively high doses. Among the possible reactions:

• use together with anticoagulants increases the likelihood of bleeding;
• weakening of the effectiveness of the hypotensive effect due to a decrease in the effect of ACE inhibitors, β-blockers, and in addition, thiazide, loop or potassium-sparing diuretics;
• combination with GCS, other NSAIDs (including selective agents that inhibit the action of COX-2) and alcoholic beverages can increase the likelihood of negative symptoms and potentiate the ulcerogenic effect;
• combination with lithium drugs or digoxin may lead to an increase in their plasma levels;
• the drug weakens the excretion of methotrexate through the tubules, which increases its toxic effect;
• when used simultaneously with probenecid, the uricosuric effect of the latter may be weakened. In addition, the excretion of indomethacin is also slowed;
• the substance sulfinpyrazone can also inhibit the excretion of indomethacin;
• It is prohibited to combine Indovenol with antitumor or hypoglycemic drugs, as well as myelosuppressants, valproic acid agents and cephalosporins;
• when combined with aliskiren, hyperglycemia may develop;
• the drug potentiates the effect of ascorbic acid on the strength and structure of vascular membranes;
• combination with sulindac may cause polyneuropathy.

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Storage conditions

Indovenol must be kept out of reach of children. Freezing the gel is prohibited. Temperature – within 25°C.

Shelf life

Indovenol is allowed to be used within 36 months from the date of release of the drug.

Application for children

The medication is prohibited for use by children under 14 years of age.

Analogues

The analogs of the drug are Ginkor Fort, Venorin, Phleboton and Indovazin with Ascorutin, as well as Ginkor gel, Vazoket, Venoruton, Troxevenol with Venosmin, as well as Troxerutin with Detralex.

Reviews

Indovenol receives quite different reviews regarding the medicinal effect it provides. Many people say that using the gel led to the appearance of allergy symptoms on the epidermis. But there are also patients who noted the high effectiveness of the drug, especially in the early stages of the disease.