Indocollir 0.1%

Indocollyre 0.1% has anti-inflammatory and analgesic properties.

Indications Indocollira 0.1%

It is used as a means of slowing down miosis before surgical procedures in the anterior chamber of the eye (for example, in the case of cataracts), and also to prevent the occurrence of Irvine-Gass syndrome after surgery.

The drug is also used in other operations in the area of the eyeball - as a therapy and prevention of the development of inflammations of various origins.

In addition, it is prescribed for the treatment of conjunctivitis of a non-infectious nature and for pain that develops after PRK sessions.

The drops are used in combination with local antimicrobial therapy – in the treatment or prevention of inflammation caused by injuries (due to wounds in the area of the eyeball, including penetrating ones).

Release form

The substance is released in the form of eye drops (0.1% liquid), inside special dropper bottles with a capacity of 5 ml. There is 1 such bottle in the box.

Pharmacodynamics

Indocollyre affects the body by slowing down the processes of PG synthesis, which are the main phase of inflammatory and pain pathogenesis. This occurs by reducing the activity of the COX enzyme under the influence of indomethacin.

The component indomethacin is an NSAID, capable of reducing the intensity of inflammation and the severity of pain when used locally. The effect develops by suppressing the development and transmission of pain impulses within neural structures. At the same time, the drug weakens the binding of thromboxane class A, which increases the bleeding period.

Pharmacokinetics

After instillation of the medication into the conjunctival sac, weak systemic absorption of the active element occurs.

Dosing and administration

To slow down miosis during surgery, it is necessary to instill 1 drop of the medicine into the conjunctival sac before the procedure. It should be repeated four times during the 2 hours before the surgery, so the intervals between instillations should be at least 30 minutes.

To prevent the occurrence of Irvine-Gass syndrome, it is necessary to instill 1 drop of the drug 3-4 times a day for 30 days after the operation.

For other disorders, the medication is administered in portions of 1 drop 3-4 times per day, over a period of 1-4 weeks. The duration of treatment and the size of the portions are selected taking into account the nature of the course of the disease and the severity of the patient's condition.

Use Indocollira 0.1% during pregnancy

No in-depth clinical tests of the drug have been conducted to determine its safety in pregnant or lactating mothers.

In this case, the use of the drug is allowed during the first 5 months of pregnancy - under the supervision of the attending physician and with the condition that the possible help for the woman is much more likely than the risk of consequences for the fetus. Then, starting from the 6th month, the drug is prohibited to use, because its use can cause a disorder in the respiratory system, cardiovascular system and kidneys of the fetus.

The active ingredient of Indocollyre, indomethacin, is excreted in breast milk, which is why breastfeeding should be avoided during therapy.

Contraindications

Main contraindications:

• severe sensitivity to the components of the drug, as well as to aspirin and other NSAIDs. Use in such people may provoke acute rhinitis, urticaria or asthma attacks;
• use in people with peptic ulcers or liver/kidney disorders.

Caution is required in the following situations:

• diagnosed or existing history of herpetic epithelial keratitis;
• hemophilia, because it leads to prolongation of bleeding;
• other diagnosed diseases associated with blood clotting disorders.

Side effects Indocollira 0.1%

The use of drops may result in the following side effects:

• visual dysfunction: mild or moderate burning, transient loss of visual acuity, hyperemia and photophobia were occasionally observed during instillation. With prolonged use of the drug, conjunctivitis or corneal opacity could develop, as well as other negative manifestations provoked by the action of indomethacin;
• signs of allergy: mainly itching or skin redness occurred.

Interactions with other drugs

Indocollyre can be used in combination with other eye drops, including those containing GCS. In this case, to prevent the drug from being washed out by further doses of other drugs, it is necessary to maintain an interval of at least 5 minutes between procedures. Among other interactions of the drug and other drugs:

• combination with lithium agents or anticoagulants leads to an increase in their indirect effect;
• combination with diflunisal may provoke the appearance of bleeding inside the gastrointestinal tract;
• Concomitant use with saluretics and β-blockers reduces the severity of their effects.

Storage conditions

Indocollyre should be kept in a dry and dark place, out of the reach of small children. Temperature values should not exceed 20°C.

Shelf life

Indocollyre can be used within 24 months from the date of manufacture of the medicine. The shelf life of the medicine with an opened bottle is 1.5 months.

Application for children

The drug is not prescribed in pediatrics.

Analogues

The analogs of the drug are Indomethacin with Metindol and Indomethacin-Zdorovye. The following eye drops also have a similar effect - Nevanak with Akuvail and Uniclofen.

Reviews

Indocollyre 0.1% can only be purchased if the patient has a prescription from a doctor, but there are quite a few reviews about it on the Internet. It should be noted that these comments differ quite significantly. Some patients note that the drug causes redness and burning in the eyes, while others talk about its high effectiveness - inflammation and pain caused by various diseases and injuries in the eye area are quickly relieved after its use.