Indocollir 0.1%

Indocollir 0.1% has anti-inflammatory and analgesic properties.

Indications Involve 0.1%

It is used as a means to slow the miosis before surgical procedures in the area of the anterior ocular chamber (for example, in the case of cataracts), and also to prevent the appearance of Irvine-Gass syndrome after surgical intervention.

The drug is used in other operations in the field of the eyeball - as therapy and prevention of the development of inflammations of various origins.

In addition, he is appointed to treat conjunctivitis, which are non-infectious in nature, and with pain developing after PRK sessions.

Drops are used in combination with local antimicrobial therapy - in the treatment or prevention of injuries caused by trauma (due to wounds in the eyeball, among which penetrating).

Release form

The release of the substance is carried out in the form of eye drops (0.1% liquid), inside special bottles with a capacity of 5 ml. In the box - 1 such a bottle.

Pharmacodynamics

Indocollar affects the body by slowing down the synthesis of PG, which is the main phase of inflammatory and painful pathogenesis. This occurs by lowering the activity of the COX enzyme under the influence of indomethacin.

The component indomethacin is an NSAID, which, when used locally, can reduce the intensity of inflammation and the degree of pain. Influence develops by suppressing the development and transmission of pain impulses within neural structures. Along with this, the drug weakens the binding of thromboxane in class A, which increases the duration of bleeding.

Pharmacokinetics

After instillation of the medication inside the conjunctival sac, a weak systemic absorption of the active element occurs.

Dosing and administration

To slow the miosis during the operation, it is required to instill a drop of 1 medicine into the conjunctival sac before carrying out the procedure. For a period of 2 hours before the operation, it must be repeated four times, so the intervals between instillations should be at least 30 minutes.

For the prevention of the appearance of Irvine-Gass syndrome it is required 3-4 times a day to instill on the 1st drop of drugs for 30 days after the performed operation.

With other disorders, the medication is administered in a dose of 1 drop 3-4 times a day, in the period 1-4 weeks. Duration of treatment and the sizes of portions are selected taking into account the nature of the course of the disease and the severity of the patient's condition.

Use Involve 0.1% during pregnancy

In-depth clinical trials of the drug regarding the safety of its use in pregnant or lactating mothers were not conducted.

It is allowed to use drugs during the first 5 months of pregnancy - under the supervision of the attending doctor and with the condition that possible help for a woman is much more likely than the risk of consequences for the fetus. Further, starting from the 6th month, the drug is prohibited, because its use can cause a disorder in the respiratory system, CCC and kidneys in the fetus.

The active element Indocollir, indomethacin, is excreted with the mother's milk, because of what it is necessary to refuse breastfeeding for the duration of therapy.

Contraindications

The main contraindications:

• strong sensitivity to the constituent elements of the drug, and in addition to aspirin and other NSAIDs. The use of such people can provoke an acute cold, urticaria or asthma attacks;
• use in people with peptic ulcers or disorders in the work of the liver / kidneys.

Caution is required in such situations:

• diagnosed or available in an anamnesis epithelial keratitis herpetic character;
• hemophilia, because this leads to an extension of the bleeding period;
• diagnosed other diseases associated with disorders of blood uptake.

Side effects Involve 0.1%

The use of drops may lead to the appearance of such side effects:

• disorders of the function of the visual organs: when instilled, there was occasionally a mild or moderate burning sensation, a transient loss of visual clarity, hyperemia and photophobia. With prolonged use of drugs, conjunctivitis or corneal opacity could develop, and in addition, other negative manifestations provoked by indomethacin;
• signs of allergy: mainly there was itching or skin reddening.

Interactions with other drugs

Indocollir can be used in combination with other eye drops, including those containing GCS. In order to prevent the leaching of the drug by the following dosages of other drugs, it is necessary to adhere to the interval between the procedures, which is at least 5 minutes. Among other drug interactions and other medications:

• combination with lithium agents or anticoagulants leads to an increase in their indirect influence;
• combination with diflunizalom can provoke the appearance of bleeding inside the gastrointestinal tract;
• simultaneous use with saluretics, β-adrenoblockers reduces the severity of their effects.

Storage conditions

Indocollar is required to be kept in a dry and dark place, closed from penetration of small children. Temperature values should not exceed 20 ° C.

Shelf life

Indocollir is allowed to be applied within 24 months from the date of release of the drug. Shelf life of the drug when the bottle is opened is 1.5 months.

Application for children

The medicine is not prescribed in pediatrics.

Analogues

Analogues of the medication are drugs Indomethacin with Metindol and Indomethacin-Health. A similar effect has also the following eye drops - Nevanak with Akuwail and Uniklofen.

Reviews

Indocollar 0.1% can be purchased only if the patient has a prescription from a doctor, but there are quite a few reviews about him on the Internet. It should be noted that these comments vary considerably among themselves. Some patients note that the medicine causes redness and burning in the eyes, while others talk about its high effectiveness - inflammation and pain caused by a variety of diseases and wounds in the eye area, are quickly weakened after its application.