Chophytol

Hofitol is a phytopreparation, has a diuretic and choleretic effect. Its effects also include reducing azotemia.

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Indications Chophytol

The medicinal product Hofitol is used in the complex treatment of the following diseases:

• Atherosclerosis;
• Chronic hepatitis (including alcoholic hepatopathy);
• Chronic acalculous cholecystitis;
• Non-alcoholic fatty liver disease (fatty hepatosis);
• Obesity;
• Dyskinesia of the bile ducts in hypokinetic form;
• Chronic intoxications (this includes poisoning with alkaloids, various hepatotoxic materials, heavy metal salts, and nitro compounds);
• Cirrhosis;
• Acetonemia;
• Oliguria occurring in heart failure syndrome or liver cirrhosis;
• Chronic renal failure;
• Chronic form of nephritis.

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Release form

1. Tablets, dosage of one 200 mg. In one package 1 tube with tablets in the amount of 60/180 pieces. Tablets are lentil-shaped, the shell is brown, at the place of fracture you can see a brown mass.
2. Solution for internal use – 1 bottle (dark glass) contains 200 ml of solution (1 ml – 200 mg).
3. Solution for parenteral use – 1 box contains 5 ampoules of medicine, 1 ampoule contains 5 ml of solution (1 ml contains 200 mg).

Pharmacodynamics

Hofitol is of plant origin and has a hepatoprotective, choleretic, and diuretic effect on the body. In addition, the drug reduces the amount of urea in the blood. The drug contains artichoke extract, which contains carotene, as well as ascorbic acid with inulin, and in addition, vitamins of groups B1 and B2. All these substances stabilize metabolism. Hofitol also increases the production of coenzymes by hepatocytes and at the same time affects the metabolism of substances such as cholesterol, lipids, and ketone bodies. During antibiotic treatment, the drug has a detoxifying effect on the renal or hepatic parenchyma. The drug removes various toxic substances from the body.

Pharmacokinetics

Artichoke extract contains a whole complex of bioactive components, such as polyphenolic elements (luteolin and cynarin, as well as various acids (including caffeic, ferulic and chlorogenic acids)), inulin, bioflavonoids, various vitamins with minerals, as well as microelements and sesquiterpene lactones. Thus, the effect of the drug is caused by the combined effect of all these substances. This is why it is impossible to conduct kinetic studies of the drug - it is impossible to track all the elements using bioassays or markers. Because of this, it is also impossible to identify all the metabolites of the drug.

Dosing and administration

Hofitol in tablets: 1-2 tablets three times a day for adults and children aged 12+. Children aged 6-12 years – 1 tablet three times a day. The treatment course lasts 2-3 weeks. New courses can be prescribed only on the recommendation of a doctor.

Hofitol in solution for internal use: prescribed in a dosage of 2.5-3 ml three times a day before meals. The treatment course usually lasts no more than 2-3 weeks. For children under 15 years old - a quarter or half of the above adult dose.

Hofitol in ampoules (intravenous and -muscular injections): adults and children 15+ years old – 1-2 ampoules per day (the dose is increased if necessary) for 8-15 days. After this period, it is allowed to switch to using a solution or tablets. Children under 15 years old can be given a quarter or half of the adult dose.

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Use Chophytol during pregnancy

During pregnancy, Hofitol can only be taken as prescribed by a doctor. Sometimes this medicine is used in the complex treatment of high blood pressure (preeclampsia), as well as in the early stages of pregnancy as a preventive measure for the development of late gestosis (if there are risk factors that can provoke the development of this disease).

Contraindications

The drug is contraindicated in cases where:

• Bile duct obstruction;
• Disorders of the liver or kidneys, as well as urinary and bile ducts (in acute form);
• Increased individual sensitivity to the components of the drug;
• Severe liver failure;
• Gallstone disease.

Side effects Chophytol

Among the side effects of the drug: if taken for a long period in large doses, diarrhea may occur. Allergy (in the form of urticaria) to parahydroxybenzoate ether, which is contained in the oral solution and tablets, is possible.

Overdose

Overdose causes an increase in the manifestations of the above side effects.

Storage conditions

The medicine must be kept at a temperature no higher than 25°C.

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Shelf life

Hofitol in tablet form is valid for 3 years. In the form of a solution for oral administration - valid for 4 years. The injection solution has a 2-year shelf life.