Heparin ointment

Heparin ointment is used to improve microcirculation of blood flow in tissues.

[1], [2], [3], [4], [5]

Indications Heparin ointment

Heparin ointment is used to improve microcirculation of blood flow in tissues, promotes the prevention of thrombosis.

[6], [7], [8], [9]

Release form

The drug is an ointment that is used for external use. The drug is produced in aluminum tubes with different weights - twenty-five, thirty and fifty grams. The tubes are placed in a cardboard box. Also, the drug is produced in plastic tubes of ten grams, enclosed in cardboard packaging. The drug is produced in jars, a capacity of twenty-five grams of the drug, made of dark glass and placed in a cardboard box. There is also a form of release of the preparation in a contour pack of ten or twenty grams, placed in a cardboard package.

One gram of Heparin Ointment contains ten thousand units of heparin, four grams of anesthesin, and eighty milligrams of benzyl nicotinate. Of the excipients indicated the presence of Vaseline, glycerin, stearin cosmetic group "D", emulsifier number one, peach oil, nipase, nipagin, purified water.

[10]

Pharmacodynamics

The components of the Heparin ointment penetrate well into the body, soaking through the skin and mucous membranes. This results in the release of sodium heparin, which helps to block thrombin production and reduce platelet aggregation. The drug has a depressant effect on the activity of an enzyme such as hyaluronidase. There is also an increase in the fibrinolytic properties of the blood. The content of nicotinic acid benzyl alcohol acts on the small surface vessels in an expanding manner, which leads to a more active absorption of heparin.

[11], [12], [13], [14], [15], [16], [17], [18], [19]

Pharmacokinetics

The maximum concentration of active substance in the blood plasma is observed three or four hours after the procedure. The properties of heparin are poor penetration through the placental barrier, since the substance has a large molecular weight. Not found in breast milk. The half-life of the Heparin ointment from the blood plasma is from half an hour to one hour.

[20], [21]

Dosing and administration

Heparin ointment is applied externally. The medicine must be applied a thin layer on the desired area of the skin. In this case, the amount of ointment per area, with a diameter of three to five centimeters, is from half to one gram. In a day, this procedure should be done two or three times before the disappearance of pain. Usually, the course of treatment is from three to seven days.

[31], [32], [33], [34], [35]

Use Heparin ointment during pregnancy

During this period the Heparin ointment is used only for the purpose of the specialist and under his personal supervision. In the lactation period, the use of the ointment is possible, if the patient is under the supervision of a doctor.

Contraindications

• The presence of hypersensitivity to the components of the Heparin ointment.
• There are various abnormalities in the anamnesis that affect the level of blood clotting.
• The patient has thrombocytopenia - a reduced production of platelets.
• Presence of ulcerative necrotic phenomena on the necessary skin area, as well as thrombophlebitis lesions.
• It is forbidden to use ointment for the treatment of open and suppurating wounds.

[22], [23], [24], [25]

Side effects Heparin ointment

• Allergic reactions - the occurrence of redness of the skin, itching, hives, swelling, the appearance of dermatitis on the treated area of the skin, as well as skin itching and increased local temperature in the feet, the emergence of drug fever, rhinitis, bronchospasm, collapse and anaphylactic shock.
• The digestive system - the emergence of nausea and vomiting, diarrhea, a decrease in appetite, the presence of an increase in the activity of liver transaminases.
• The circulatory system - the possibility of bleeding from the gastrointestinal tract and urinary tract, as well as bleeding at the site of ointment application; there are hemorrhages in other organs; there may be hematuria and thrombocytopenia.
• Musculoskeletal system - prolonged use of the drug leads to the development of osteoporosis, spontaneous fractures, calcification of soft tissues.

[26], [27], [28], [29], [30]

Overdose

Overdose of Heparin Ointment is manifested in the occurrence of bleeding. In this case, you must stop using the medicine and seek medical help as soon as possible.

[36], [37], [38], [39], [40]

Interactions with other drugs

The action of the main component can enhance such drugs as anticoagulants, antiaggregants and non-steroidal anti-inflammatory drugs. It is forbidden to use Heparin ointment in joint treatment with other non-steroidal anti-inflammatory drugs. The same prohibition concerns antibiotics from the group of tetracyclines and antihistamines. The action of ergot alkaloids, thyroxine, tetracyclines, antihistamines, and nicotine helps to decrease the activity of the main component of the ointment.

[41], [42], [43], [44], [45], [46]

Storage conditions

Heparin ointment - in a place that is not accessible to children, in a dry room, which is protected from sunlight, at temperatures up to 20 ° C.

[47], [48], [49], [50], [51]

Shelf life

Heparin ointment is stored for thirty-six months from the date of manufacture indicated on the tuba.

[52], [53], [54], [55]