Helicocin

Helicocin is a medicament for antimicrobial action. Consider the main indications for its use, possible side effects and contraindications.

Helicocin is part of the pharmacological group of agents used in complex therapy for the eradication of Helicobacter pylori. 

Tablets are taken only for medical purposes. During treatment it is necessary to exclude the use of alcohol, since there is a risk of adverse reactions due to interaction with metronidazole. If the medicine has become the cause of persistent diarrhea, then without proper treatment, pseudomembranous colitis threatening life can develop.

Indications Helicocin

As a rule, tablets are prescribed in the complex therapy of microbial lesions of the body.

Indications for use Helicocin:

• Eradication of Helicobacter pylori on the gastric mucosa.
• Treatment of acute and chronic gastritis, peptic ulcer of the stomach and duodenum caused by Helicobacter pylori (used in conjunction with other medicines).

The drug is taken only for medical purposes. With complex therapy, all drugs are selected very carefully to avoid side effects when interacting.
 

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Release form

The medication has a tablet form of release. The medicine is produced in cardboard packages in blisters for 6 and 12 pieces. The tablets are round and oval in shape, covered with an enteric coating of white color. The tablet of the round form contains an active substance - amoxicillin 750 mg, and the active component of the oval tablet is metronidazole 500 mg.

Pharmacodynamics

The effect of the drug is due to the substances that make up its composition.

• Amoxicillin is a bactericidal agent, a broad-spectrum penicillin.
• Metronidazole - has bactericidal properties, is a derivative of nitromidazole.

Pharmacodynamics of the drug indicates that both active components complement each other, which has a harmful effect on Helicobacter pylori. Amoxicillin inhibits the development of Helicobacter pylori resistance to the second component. The use of a combination of these substances prevents the development of relapses of peptic ulcer of the gastrointestinal tract.

Pharmacokinetics

Since the drug has two active substances, information about the mechanism of their action after ingestion allows you to know about the effectiveness of therapy.

Pharmacokinetics Helicocin:

• Amoxicillin - after oral administration is completely absorbed in the small intestine. Food intake does not affect the rate of absorption. The maximum concentration in the blood plasma occurs in 1-2 hours. The medicine is distributed in soft tissues and body fluids. It is excreted by the kidneys, the elimination half-life takes 1-2 hours.
• Metronidazole - quickly and completely absorbed, the maximum concentration in the serum is achieved 1-2 hours after ingestion. Eating delays absorption, but does not affect the level of absorption. The substance penetrates into soft tissues and is distributed into them. It is excreted by the kidneys, the half-life takes about 6-8 hours.

Active components do not affect the pharmacokinetics of each other, which indicates the effectiveness of this combination drug.

Dosing and administration

Depending on the indications for use, each patient is selected an individual way of use and dose. Helicocine is taken orally on 1 tablet of both types 2-3 times a day. Duration of treatment is 12 days. If the patient has severe impairment of kidney and liver function (Cl creatinine below 30 ml / min), then take 1 tablet 2 times a day, in the morning and in the evening.

Use Helicocin during pregnancy

Many antimicrobial agents of systemic action are not recommended for eradication of Helicobacter pylori during gestation. Use of Helicocin during pregnancy is contraindicated, since active substances adversely affect the development of the fetus.

• Amoxicillin can penetrate the placental barrier and is excreted in breast milk.
• Metronidazole is not prescribed in the first trimester and with lactation. With special care is used in II-III trimesters.

If you need to use the drug during pregnancy, you need to carefully evaluate the expected benefit of treatment for the mother and the potential risk to the child.

Contraindications

Helicocin has certain limitations for use for medicinal purposes. Medication is not prescribed for individual intolerance of one of the active substances, during pregnancy and lactation, with acute diseases of the central nervous system and hematopoiesis.

Contraindications:

• Amoxicillin - infectious mononucleosis, gastrointestinal infections, allergic diathesis, respiratory viral infections, individual intolerance to penicillins, lymphocytic leukemia.
• Metronidazole - leukopenia (anamnesis), CNS lesions, pregnancy and lactation, renal and hepatic insufficiency.

Helicycin is not used to treat children of childhood.

Side effects Helicocin

As a rule, the drug is well tolerated. Side effects of Helicocin occur when non-compliance with medical recommendations for use. Most often, patients complain of such adverse reactions:

• Lack of appetite
• Vomiting and nausea
• Diarrhea
• Unpleasant metallic taste in the mouth and dryness
• Nasal congestion
• Stomatitis
• Cystitis
• Staining of urine in a dark color
• Allergic reactions
• Dizziness
• Increased weakness and headaches

To eliminate these symptoms, it is recommended that you stop taking the medicine and seek medical help.

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Overdose

Increased doses of the drug or its long-term use may lead to adverse symptoms. Overdose occurs extremely rarely and is accompanied by such phenomena:

• Nausea
• Vomiting
• Dizziness
• Headache
• Increased fatigue
• Drowsiness / insomnia
• Various allergic reactions

To eliminate the above symptoms, it is recommended that you stop taking the pills and see a doctor to adjust the dosage.

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Interactions with other drugs

Destruction of Helicobacter pylori involves the use of several drugs at the same time. Consider the interaction of Helicocin with other drugs:

• Amoxicillin - when used with Allopurinol, the risk of skin allergic reactions increases and the effect of oral contraceptives decreases. The substance affects the results of the urine test, increasing the sugar content in it.
• Metronidazole - when used with disulfiram causes psychotropic symptoms. Interaction with Doxycyclines causes potentiation of the protianaerobic effect. The substance enhances the anticoagulant effect of Warfarin.

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Storage conditions

To preserve the medicinal properties of the drug, it is very important to observe the conditions of its storage. Tablets should be kept in their original packaging, protected from moisture, sunlight and inaccessible to children. Storage temperature should not exceed 25 ° C.

Failure to comply with these recommendations leads to damage to the medicament and the loss of its medicinal and physicochemical properties.

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Shelf life

Helicocin must be used within 48 months from the date of manufacture. The shelf life of the drug is indicated on its packaging. The use of an overdue medication is contraindicated, since it can cause uncontrolled reactions from many organs and systems.