Hayes-sterile 10%

Hayes steril 10% is a medicinal product that is used for surgical purposes during operations and blood transfusion. Let's consider the features of this drug, pharmacodynamics and pharmacokinetics, side effects, methods of taking and dosage.

Hayes steril 10% is a clear solution, which includes: sodium chloride, hydrochloric acid, sodium hydroxide, hydroxyethyl, starch, water for injection and other components. The drug is a solution for infusion, pharmacotherapeutic group of the drug - perfusion solutions and blood substitutes.

Indications Hayes-sterile 10%

Indications for use Hayes steril 10% are directly related to the pharmacotherapeutic group of the drug. Let's look at the main indications for using this medicine.

• Prevention and treatment of hypovolemia and hemorrhagic shock during surgical interventions.
• Treatment of traumatic lesions, traumatic shock.
• Burn infections and burn shock, septic infections.
• Normovolemicheskaya (acute) hemodilution in surgical interventions to reduce the introduction of donor blood.
• Prevention of hemodilution for therapeutic purposes.

Release form

The form of the preparation - glass and plastic bottles of 500 ml and 250 ml with 10% and 6% solution for infusion. The drug is sold as a unit, as well as 10 bottles in a package. The advantage is given to the plastic bottles, since they do not require special transportation rules and are less prone to damage, which is not the case with glass bottles with Hayes-sterile 10%.

Transparent bottles with the drug can visually see the solution. So, in case of non-observance of the storage conditions or the expiration of the shelf life in the Hayes-sterile solution, 10% may appear small flakes, and the drug itself may change its color or become cloudy.

Pharmacodynamics

Pharmacodynamics Hayes-steril 10% gives an opportunity to learn about how the drug behaves after getting into the body and how the active substances of the drug work. Active ingredient Hayes steril 10% is an artificial colloid of hydroxyethyl starch, which is obtained from amylopectin. The average molecular weight of the substance is 200,000 Daltons, and the substitution is 0.5. Such data suggest that the glucose residues of the drug are hydroxyl groups that are close to glycogen. Due to this, the drug is well tolerated and has a low risk of developing anaphylactic reactions.

Infusion Heyes steril 10% 500 ml is designed for 15 minutes of drip. Use in hypovolemia leads to an increase in plasma volumes by more than 140% one hour after administration and 100% after 2 hours. Hayes-steril 10% improves hemodynamics and microcirculation for 3-5 hours.

Pharmacokinetics

Pharmacokinetics Hayes-sterile 10% are the processes of administration, distribution, absorption, metabolism and excretion of the drug. After administration, the active substance of the drug undergoes cleavage (fermented) blood, which leads to the appearance of polysaccharides with different molecular weights.

The drug is excreted, as a rule, through the kidneys, half of the administered dose of the drug goes with the urine within 24 hours. A small amount of Hayes sterile 10% is deposited in tissues, about 10% continues to work in the serum. Another substance of the drug - sodium chloride is removed with sweat through the skin.

Dosing and administration

The way of application and the dose of the drug depend on the purpose of use and are prescribed by the doctor, individually for each patient. The drug is used as an intravenous infusion. The solution is administered slowly, so when an initial 20 ml of the drug is administered, anaphylactic reactions are possible. The daily dose and the rate of infusion administration depend on the degree of hemoconcentration and blood loss. Hayes steril 10% has therapeutic limits, which depend on the degree of dilution of the drug.

If the drug is used to prevent or treat a deficiency of hypovolemia, the maximum dose for adults is 20 ml per kg of body weight per day, the infusion rate is 20 ml / kg. The maximum daily dosage and rate of administration are prescribed by the physician and depend on the individual characteristics of the patient's body.

Use Hayes-sterile 10% during pregnancy

Use of Hayes steril 10% during pregnancy, like any other drug is not desirable. However, no studies have been carried out regarding the effect of the drug on the mother's organism and the developmental processes of the baby. The drug Hayes steril 10% during pregnancy and breastfeeding is prescribed according to the mother's vital indications and only if the potential benefit for the woman is much more important than the possible risk to the child's organism.

When using the drug in pregnant women, side effects may occur. In this case, it is recommended to stop using the drug and conduct therapeutic procedures to cleanse the body of the active substances Hayes-steril 10%.

Contraindications

Contraindications to the use of Hayes steril 10% are associated with the individual characteristics of the patient's body. But there are a number of cases when the drug is prohibited to use, that is, it has contraindications for medical reasons. Let's consider the main contraindications to the use of Hayes-sterile 10%.

• Heart failure;
• Renal failure;
• Intracranial bleeding and blood coagulation disorders;
• Allergy to starch;
• The patient's age is up to 10 years, the period of pregnancy and lactation;
• Intracranial and arterial hypertension;
• Hemorrhagic diathesis and hypocoagulation;
• Cardiogenic pulmonary edema and hypervolemia;
• Thrombocytopenia and hemodialysis.

Before taking the drug, the doctor conducts a diagnosis of the patient's body to determine possible contraindications. If contraindications exist, then Hayes steril 10% is replaced by safer analogs or the safest dosage is selected.

Side effects Hayes-sterile 10%

Side effects of Hayes steril 10% may occur when the drug is used by patients who have contraindications to the use. Side effects occur due to an incorrectly prescribed dose or with prolonged use. Very rarely Hayes steril 10% causes anaphylactic reactions of varying severity. Also, there may be allergic skin reactions, tachycardia, lowering of blood pressure, headache and dizziness.

With prolonged use of Hayes sterile 10% or the use of high doses, patients may experience severe itching, which is almost not treatable. In other patients, the drug causes vomiting, bronchospasm, and can lead to the stopping of breathing and the work of the heart. High dosage of the drug is the cause of bleeding. That is why, when using Hayes-steril, 10% pay special attention to the time of drug administration, the duration of treatment and dosage.

Overdose

Overdosage of the drug Hayes-steril 10% may occur because of too rapid administration of the drug or because of an incorrectly calculated dosage. Thus, high doses of the drug may cause prolongation of bleeding time, but do not cause clinically dangerous bleeding. Because of an overdose, the level of hematocrit and protein can decrease.

In order to avoid the appearance of overdose symptoms, the drug is injected very slowly. During the infusion, the doctor observes the patient's condition and controls the rate of administration. When symptoms of an overdose appear, Hayes-steril 10% is stopped to be used for treatment and prevention, replacing it with a safer analogue.

Interactions with other drugs

Interaction Hayes-steril 10% with other drugs is possible only according to the doctor's prescription. If the drug interacts with aminoglycoside antibacterial agents, then it is possible to enhance the nephrotic effect, that is, a negative effect on the kidneys. Hayes steril 10% is not recommended to be mixed with other drugs and administered simultaneously. Since this can become a causal anaphylactic shock, cause bleeding and other side effects.

Injections of other drugs are recommended to be done 2-3 hours after the administration of Hayes-sterile 10%. This will avoid undesirable drug interactions. In addition, with consistent administration, there is a guarantee that all antibiotics will be properly absorbed by the body and exert their healing effects without losing them.

Storage conditions

Storage conditions of Hayes steril 10% are described in the drug's instructions. The drug should be stored in a cool place, which is protected from sunlight and children. Storage temperature should not exceed 25 ° C.

Please note that failure to comply with storage conditions leads to damage to the drug. Due to temperature differences, Hayes sterile 10% can change its consistency, from a clear solution to a cloudy liquid with flakes. In this case, the use of the drug must be abandoned.

Shelf life

Shea-sterile 10% is five years from the date of manufacture, which is indicated on the package of the preparation. The preparation should be stored in the original packaging, observing the storage conditions of Hayes steril 10%, which are indicated in the drug's instructions. After the expiration date, the drug must be disposed of. Use Hayes Steril 10% at the expiration date is strictly prohibited.