Haloperidol forte

Haloperidol forte belongs to a group of drugs that are designed to treat psychotic disorders. To date, quite often there are people suffering from acute and chronic forms of this process. In this situation, you can not leave everything on its own, you need complex therapy and maintenance of the human condition.

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Indications of the haloperidol forte

Indications for use Haloperidol forte unambiguous, this is a mental disorder. And they can take absolutely any form. These disorders include schizophrenia, epileptic, depressive and alcoholic psychoses.

They take the medicine in case of psychomotor agitation of different genesis. Hallucinations, depression and psychosomatic disorders are eliminated. To date, many people suffer from stuttering, caused by problems with an uneven system. Take the remedy in this case is necessary. Remove these effects can be, in more complex situations, the drug is used as maintenance therapy.

Oligophrenia, disorders associated with childhood and old age are the main indications for use. Vomiting, hiccough, elimination of nausea and other unpleasant symptoms caused by chemotherapy. In all these cases, a medication is taken. Galoperedol forte is a universal tool that can help in solving many problems, but it is not recommended to take it alone. 

Release form

The form of the product is presented in tablets. So, it contains 5 mg of active substance haloperidol. Additional constituents are silicon oxide, magnesium stearate, talc, starch and lactose.

Tablets are white in color, in some cases approximate shade. Practically there is no smell, the medicine looks like a flat disc. This simplifies the swallowing process.

There is no other form of output. Haloperidol forte is presented exclusively by tablets. This form allows you to take them with you and take them at any convenient time.

Acquiring a drug in a pharmacy, it is worth paying attention to the appearance. Tablets should not have a different shade, except white. Along with the packaging in the kit is an instruction. Without it, take the remedy is not worth it. The pharmacist must report the instruction, in case of its absence. You need to buy the drug in the place and quantity that you need. Haloperidol forte is a universal medication that makes it possible to relieve a person's condition in a short time. 

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Pharmacodynamics

Pharmacodynamics of the drug is an antipsychotic agent, which is a derivative of butyrophenone. The drug has a pronounced antipsychotic effect. This process is caused by a blockade of depolarization or a decrease in the degree of excitation of dopamine neurons.

The drug has a moderate sedative effect. This is due to the blockade of α-adrenoreceptors in the brain stem. This allows you to influence the vomiting center in a way, and remove unpleasant symptoms.

Long-term use of the drug may be accompanied by a change in the endocrine status. This process occurs in the anterior pituitary gland. Here, prolactin production increases and production of gonadotropic hormones decreases significantly.

The agent has almost no anticholinergic action. Haloperidol forte is able to eliminate persistent changes in personality, mania, and increase a person's interest in the world around them. In addition, there is an activating action. Children with hyperactivity become slightly calmer after taking the drug, excessive motor activity is eliminated. Haloperidol is characterized by prolonged action. 

[3], [4]

Pharmacokinetics

The pharmacokinetics of the drug is due to rapid absorption. So, the drug is absorbed from the gastrointestinal tract by almost 60%. The maximum concentration of active substances in the plasma is reached in 3-6 hours after the person took the medicine. If it was an intramuscular injection, then after 10-20 minutes.

The effect of the "first passage" occurs in the baking. The agent binds to proteins by 92%. With the participation of isoenzymes, active substances are metabolized in the liver quite actively. There are no active metabolites.

During taking the medicine inwards, it is absorbed by 60% of the gastrointestinal tract. It is able to easily penetrate through the histohematological barriers, including the BBB. The drug is excreted together with breast milk when taken in after 24 hours. If the medicine entered the body intramuscularly, then after 21 hours. The drug is completely eliminated from the body after 3 weeks. Through the kidney leaves 40%, and through the intestines with the help of bile 15%. Haloperidol forte does not carry a high risk to the body. 

[5], [6], [7]

Dosing and administration

Dosage and administration Haloperidol forte is determined by the attending physician. During ingestion, the initial dose is 0.5-5 mg of the drug up to 3 times a day. If it is a question of patients of advanced age, the dosage does not exceed 0.5-2 mg. In the future, everything depends on the treatment itself. In most cases, the dose increases to 5-10 mg.

Elevated doses of 40 mg are very rare. In periods of absence of concomitant diseases. For children, the dose should not exceed 25-75 mcg for 2-3 doses. If intramuscular injection is necessary, the initial dosage is 1-10 mg. The interval between such administrations should be 1-8 hours.

When administered intravenously, a single dose is 0.5-50 mg. The frequency of administration depends on the clinical situation. Maximum can be administered at 100 mg per day. If a depot form is taken, then about 300 mg per month. In general, a lot depends on the state of a person, and the disease that he suffers. Haloperidol forte should be taken in strict accordance with the doctor's recommendations. 

[9], [10], [11],

Use of the haloperidol forte during pregnancy

The use of haloperidol forte during pregnancy is contraindicated. The same situation applies to the period of breastfeeding. Due to the conducted studies it was revealed that in most cases the drug has a teratogenic and fetotoxic effect.

The drug is able to excrete, along with breast milk, the mother. And its concentration is significant, which can negatively say on the health of the baby. Possible manifestation of sedation and impaired motor function in the newborn.

If you need to take the product, you should consult your doctor. After all, the consequences of independent use can be serious. It should be understood that the child suffers more directly.

During breastfeeding the medicine is not accepted, during this period, alternative ways of solving the problem are selected. If a woman becomes pregnant at the time when the active phase of treatment has passed, the attending physician reports the possible pathologies of the child. Do not take haloperidol forte in children and pregnant women in any case. 

Contraindications

Contraindications to the use of haloperidol forte are mainly in the presence of allergic reactions to certain components of the drug. To this number are people suffering from diseases of the central nervous system. Especially those that are accompanied by extrapyramidal disorders, hysteria, depression and coma.

Severe toxic oppression of the central nervous system is also one of the main contraindications. Especially if it is caused by medications. Lactation and the period of pregnancy do not provide for taking this medication.

At the age of up to 3 years, use of the product is not recommended. Hypersensitivity to the active ingredient haloperidol is a special risk group. People who suffer from this phenomenon should not take the remedy. The manifestation of an allergic reaction can also be of an extremely complex form. This is why it is not recommended to take the drug on your own. Haloperidol forte can cause serious harm to the body.      

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Side effects of the haloperidol forte

Side effects of haloperidol forte manifest themselves in different ways. So, from the central nervous system can be seen headache, a constant feeling of anxiety or fear, euphoria, constant drowsiness, overexcitation and even an attack of epilepsy.

The cardiovascular system responds to the manifestation of tachycardia, ECG changes, arrhythmia and alternative hypotension. But this is possible only if too large doses are received.

Digestive system: dry mouth, nausea, vomiting, constipation, or vice versa, diarrhea, impaired liver function. And the last symptom can lead to the development of jaundice.

In rare cases, from the hematopoiesis manifests itself leukocytosis, a slight erythrogenia or a tendency to monocytosis. The endocrine system reacts in the form of increased libido, menstrual cycle disorders, and pain in the mammary glands.

Metabolism: increased sweating, a significant increase in body weight, edema and hyponatremia. Violation of visual acuity, accommodation, there is cataract and retinopathy.

Possible allergic reactions in the form of skin rashes, hyperpyrexia, laryngospasm and bronchospasm. It is possible the manifestation of hyposalization and maculopapule changes in the skin. All this can cause haloperidol forte if it is not applied correctly. 

Overdose

Overdose Haloperidol forte is not excluded. So, this process can manifest itself in the form of acute neuroleptic reactions. In particular, the temperature rise must be frightening. Often this indicates the presence of a malignant neuroleptic syndrome. So to say this is one of the most basic symptoms of its manifestation.

In severe cases, an overdose can lead to a violation of consciousness, it is possible the manifestation of coma. If there are negative reactions from the body, you should immediately resort to treatment.

There is a suspension of therapy with neuroleptics, intravenous diazepam, nootropics, B and C. Vitamins are administered. Mandatory symptomatic therapy.

A person who is in a presyncopal state needs to maintain the patency of the airways. It is necessary to monitor the functions of breathing and the parameters of blood circulation. It is desirable to constantly monitor the condition when the cardiovascular system is affected. It is recommended to take diazepam. All these actions will ease the impact of haloperidol forte on the body. 

[12], [13]

Interactions with other drugs

Interactions with other drugs are not excluded, but in this case it is necessary to exercise special care. If you simultaneously take this medication with others that have central nervous system depression, you may develop depression. Do not rule out depression of breathing and hypotensive effect. All this requires a doctor's consultation.

During the use of drugs that have extrapyramidal reactions, the frequency and severity of extrapyramidal effects may be excluded. Means that have anticholinergic activity can enhance the manifestation of these actions.

Do not take the drug with anticonvulsants. In this case, the frequency of epileptiform seizures may change. Galoperedol forte is able to potentiate the effect of antihypertensive agents. Along with beta-adrenoblockers, arterial hypotension can manifest itself.

 Under the influence of the drug, a sharp decrease in the therapeutic effect of levodopa is possible. This is due to the blockade of dopainic receptors. Simultaneous administration of fluvoxamine may cause an increase in the concentration of the drug in the blood plasma. This is accompanied by a serious toxic effect.

Admission with fluoxetine is able to develop extrapyramidal symptoms and dystonia. There may be an increase in the concentration of haloperidol forte in the blood plasma. 

[14], [15]

Storage conditions

The storage conditions of haloperidol forte must be observed without fail. The main role in this process is played by the temperature regime. It should not exceed 15-25 degrees. It is clearly not worthwhile to give the agent a freeze. After such an impact, it loses its active properties and is unsuitable for use.

It is advisable to fence off access to the drug. Children are quite curious and look into the box with the pills they just want. Ultimately, the drug can be tested for taste. For a child's body, such an effect is unacceptable. Perhaps the development of pathologies that will not be possible to correct.

It is important that the storage area is not exposed to direct sunlight. It is recommended to exclude and get damp. All this has a detrimental effect on the shelf life of the medication. It is necessary to provide a dry, warm and that the most important thing is a dark place. Haloperidol forte requires certain storage conditions, because only in this way you can keep its useful properties for a long time. 

[16], [17], [18]

Shelf life

Shelf life of the drug is long and is 5 years. Keep the tool for such a time will not be difficult if you follow certain rules. So, it is desirable to immediately allocate a dry and warm place for the medicament, where sun rays do not penetrate.

Perfectly suitable for ordinary medicine cabinet. The main thing is that it does not have open access for children. Haloperidol forte can adversely affect the baby's body and lead to the development of serious problems.

In no case should the drug be frozen. In this case, this is unacceptable. After treatment with cold, the drug may lose all its positive properties. In the end, it can not be accepted.

Particular attention is paid to the appearance of tablets. It is indicated that their color does not fluctuate in white and close to him tones. If the medicine looks completely different, then most likely the storage conditions were not met correctly. In this case, haloperidol forte is not tolerable, and must be removed from the home medicine chest. 

[19], [20]