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Gynoflor E
Last reviewed: 04.07.2025

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Gynoflor E is a medical product containing a combination of two active ingredients:
- Lactobacillus acidophilus: These are friendly microorganisms that naturally live in the vagina of healthy women and help maintain vaginal health. They help maintain normal vaginal pH, inhibit the growth of pathogens, and may prevent infections.
- Estriol: This is a natural estrogen that may be helpful in restoring and maintaining the health of the vaginal mucosa. It helps to moisturize and strengthen the tissue, which may help reduce symptoms of dryness, itching, and irritation.
Gynoflor E is commonly used to treat and prevent various female vaginal infections, such as bacterial vaginosis, thrush and other vaginal dysbacteriosis. It can also be recommended for women during menopause to improve the condition of vaginal tissues.
The dosage and mode of application of Gynoflor E are usually indicated in the instructions for the drug or prescribed by a doctor depending on the specific situation.
Indications Gynoflora E
- Treatment and prevention of vaginal infections: Including bacterial vaginosis, thrush (vaginal candidiasis) and other vaginal dysbacteriosis caused by disruption of the microbiocenosis.
- Reducing the risk of recurrence of vaginal infections: Gynoflor E can be used to prevent recurrent episodes of vaginal infections in women prone to frequent recurrences.
- Improving the condition of the vaginal mucosa: Estriol contained in the drug helps to restore and maintain the health of the vaginal mucosa, especially in cases of dryness, itching, irritation and other uncomfortable symptoms.
Release form
Vaginal tablets or capsules: These forms of the drug are inserted into the vagina and can be used to treat or prevent vaginal dysbiosis (imbalance of vaginal microflora) or other vaginal infections. They can also be used to restore the natural microflora after a course of antibiotics or other medical procedures.
Pharmacodynamics
Lactobacillus acidophilus:
- Probiotic action: Lactobacillus acidophilus is a normal microorganism that inhabits the vagina. It helps maintain normal vaginal microflora by creating an acidic environment that inhibits the growth of pathogenic microorganisms.
- Anti-inflammatory effects: Some studies suggest that lactobacilli may reduce inflammation in the vagina and lower the risk of urinary tract infections in women.
- Strengthening the immune system: Lactobacilli help strengthen the immune system, which can also help fight infections.
Estriol:
- Estrogenic action: Estriol is an estrogen that has an agonistic effect on estrogen receptors in vaginal tissue. It can help restore estrogen balance, improving the tone and elasticity of vaginal tissue.
- Moisturizing and softening of the mucous membrane: Estriol helps to moisturize and soften the vaginal mucosa, which can be helpful for dryness and irritation.
Pharmacokinetics
Information on the pharmacokinetics of Gynoflor E (Lactobacillus acidophilus, estriol) may be limited due to the nature of this drug. Lactobacillus acidophilus are live microorganisms that are normally found in the normal microflora of the human body. The pharmacokinetics of such probiotics may include their survival and colonization in the intestine, but this depends on many factors, including the individual characteristics of the organism and the patient's condition.
As for estriol, it is an estrogen that may have its own pharmacokinetic properties, including metabolism and elimination from the body. However, when combined with lactobacillus acidophilus, its pharmacokinetics may be modified.
Dosing and administration
Inserting the tablet:
- Gynoflor E is inserted vaginally, preferably at bedtime to minimise leakage and maximise exposure overnight.
- Before inserting the tablet, hands and vaginal area should be clean and dry.
- The tablet should be inserted as deeply into the vagina as possible using a finger or a special applicator if provided.
Course duration:
- The course of treatment and prevention may vary depending on the doctor's instructions and individual needs.
Dosage:
- Standard scheme:
- For the treatment of vaginal atrophy associated with menopause, it is often recommended to start with one tablet daily for the first two to three weeks, then move on to maintenance therapy, such as one tablet twice a week.
- Prevention of recurrence of vaginal infections:
- To maintain normal vaginal microflora, you can use one tablet two to three times a week for a long period, as agreed with your doctor.
Special instructions:
- Do not use vaginal douches during treatment with Gynoflor E, as this may reduce the effectiveness of the medicine.
- If you forget to take a dose, take it as soon as possible, but if it is almost time for your next dose, skip the forgotten dose and continue as usual.
- During menstruation, you can continue using the drug if it is comfortable for you, or discuss with your doctor a possible break.
Use Gynoflora E during pregnancy
Information on the safety of using Gynoflor E during pregnancy may be limited.
Contraindications
- Individual intolerance: People with known individual intolerance to lactobacilli acidophilus, estrol or any other components of the drug should avoid its use.
- Pregnancy: There is no data on the safety of using Ginoflor E during pregnancy. Therefore, its use during this period should be carried out only after consultation with a doctor.
- Age restrictions: The use of this drug in children and adolescents may be limited, as data on its safety and effectiveness in this age group may be limited.
- Vaginal infections: The use of Gynoflor E may be contraindicated in the presence of vaginal infections, such as vaginitis or other inflammatory processes, until an accurate diagnosis has been established and the underlying disease has been treated.
- Other health conditions: Use of this medicine may be limited in patients with certain health conditions, such as immunodeficiency states or autoimmune diseases, due to possible risks or the need for special medical supervision.
Side effects Gynoflora E
Local reactions:
- Vaginal irritation or discomfort: Some women may experience mild burning, itching, or irritation after inserting the tablet.
- Increased vaginal discharge: Use of the drug may result in increased vaginal discharge.
- Vaginal bleeding: Although this is a less common effect, some women may notice light vaginal bleeding or spotting.
Allergic reactions:
- Rarely, allergic reactions to one of the components of the drug are possible, which may manifest as hives, itching, swelling and severe respiratory reactions.
Systemic hormonal effects:
- Although estriol in Gynoflor E is applied topically and in low doses, systemic hormonal effects are theoretically possible, especially with long-term use.
Overdose
Information on overdose of Gynoflor E, a product containing lactobacilli acidophilus and estriol, is generally limited due to its safety profile. However, if the recommended dose is exceeded or large amounts of the product are accidentally consumed, various adverse effects may occur.
Since lactobacilli acidophilus are part of the normal vaginal flora, their excess may not lead to serious consequences. However, uncontrolled proliferation of lactobacilli can lead to changes in vaginal pH and the development of irritation or dysbiosis.
As for estriol, excessive use can cause excess estrogen levels in the body, which in turn can lead to unwanted effects such as dizziness, nausea, breast tenderness or heaviness, and possibly increased symptoms of premenstrual syndrome.
Attention!
To simplify the perception of information, this instruction for use of the drug "Gynoflor E" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.