Givalex

Givalex is a member of the antiseptic group. Its medicinal activity is associated with the action of 3 active elements.

Hexetidine has antibacterial activity against various gram-negative and -positive bacterial strains (anaerobes and aerobes). [ 1 ]

Choline salicylate is used for the treatment of diseases in the oral cavity.

Chlorobutanol can be used in otolaryngology (rinses or nasal drops) and dentistry (irrigations or applications). It can also be used as an anesthetic.

The active ingredients are fixed on the oral mucosa, from which they are then gradually released.

Indications Givalex

It is used for local treatment of oral infections (gingivitis, stomatitis ), as well as after dental surgery.

Release form

The medicine is released in the form of a 125 ml bottle (the kit also includes a 50 ml dosing cup).

Pharmacodynamics

Antifungal and antibacterial effects. [ 2 ]

Hexetidine has a bacteriostatic effect on aerobic strains; the bactericidal effect is quite weak (it is expressed in relation to anaerobes). The principle of action is associated with competitive activity with thiamine: its structure is similar to the thiamine structure required for bacterial growth. [ 3 ]

Anti-inflammatory effect.

Choline salicylate has antipyretic, anti-inflammatory and analgesic effects.

Analgesic effect.

Chlorobutanol has an analgesic effect.

Dosing and administration

Use for local treatment of the mouth (rinsing). To perform one procedure of rinsing the mouth, you need to pour the medicinal liquid into a dosing cup to the level of 10 ml, and then add warm water to it (to the level of 50 ml). You can also dilute 2 teaspoons of Givalex in warm plain water (¼ cup).

2-4 rinses are performed per day. It is forbidden to swallow the medicinal substance. The therapeutic cycle lasts 5 days.

• Application for children

It is prohibited to use the medication in persons under 6 years of age.

Use Givalex during pregnancy

There is no information on whether hexetidine can cross the placenta and be excreted in breast milk, which is why Givalex is not prescribed during breastfeeding and pregnancy.

Contraindications

Main contraindications:

• severe intolerance to the components of the drug;
• atrophic pharyngitis;
• Asthma or other respiratory tract disorders caused by existing hypersensitivity of the respiratory tract.

Side effects Givalex

Side effects include:

• immune disorders: symptoms of intolerance, including Quincke's edema, urticaria, bronchial spasm and laryngospasm;
• problems with the functioning of the nervous system: dysgeusia and ageusia, as well as taste disturbances for a period of 48 hours (the taste of “sweet” changes to the taste of “bitter”);
• disorders associated with the organs of the sternum and mediastinum, as well as with the respiratory system: dyspnea and cough;
• digestive disorders: dysphagia, pain when swallowing, xerostomia and enlargement of the salivary glands. Swallowing medication can cause problems with the gastrointestinal tract (usually vomiting with nausea);
• lesions of the subcutaneous layer and epidermis: contact dermatitis of an allergic nature and epidermal symptoms (rashes);
• local manifestations: temporary change in the color of the tongue and teeth, hypersensitivity of the mucous membrane (numbness and burning sensation), irritation (itching, pain and feeling of heat) of the oral mucosa or tongue, inflammation, decreased sensitivity, and in addition, paresthesia in the mucous membrane area, the appearance of blisters, development of ulcers on the mucous membrane, irritation, dryness of the throat/nasal mucosa and swelling in the contact area.

Overdose

The probability of acute poisoning is very low. If a child accidentally takes a large dose of the drug orally, alcohol poisoning may develop, since the medication contains ethanol.

If a child swallows the medicine, seek medical help immediately. It is possible to perform gastric lavage within 2 hours of swallowing and carry out procedures to help eliminate the symptoms of alcohol poisoning.

Interactions with other drugs

It is prohibited to combine Givalex with substances that contain antiseptics.

Alkaline solutions may inactivate hexetidine.

Storage conditions

Givalex should be stored in a place closed to small children. Temperature indicators – no more than 25°C.

Shelf life

Givalex can be used within a 1.5-year period from the date of manufacture of the pharmaceutical substance.

Analogues

The analogs of the drug are Lorangin with Angilex-Zdorovye and Hepilor with Grippocitron Lor.