Gidazepam

Gidazepam is a psycholeptic used in the treatment of psycho-neurotic disorders.

The medication is a benzodiazepine derivative; it has a selective anxiolytic effect and is a mild daytime tranquilizer. The drug combines an antidepressant effect, as well as an activating and anxiolytic effect. The drug has low toxicity and causes a minimum of side effects. When used in moderate doses, it has no hypnotic effect and does not increase the rate of onset of fatigue. [1]

Indications Gidazepam

It is used as a daytime drug for psychopathic asthenia and neurotic disorders. It can also be used before a surgical procedure or painful surgery that provokes feelings of anxiety and fear.

In addition, the medication is prescribed in case of emotional instability and aggressive behavior, as well as a supportive agent in the treatment of alcoholism .

Release form

The release of the drug substance is realized in the form of tablets - 10 or 20 pieces inside the cell pack; inside the box - 1 or 2 packs.

Pharmacokinetics

Gidazepam is absorbed inside the body at a fairly high rate, and its effect develops after 40-60 minutes. Indicators of the highest efficiency and Cmax reach after 1-4 hours, and then its effect decreases. The effect of sublingual tablets begins already after 15-20 minutes. [2]

The drug has a high level of bioactivity - it penetrates the kidneys, adipose tissue, liver; only a dealkylated metabolic element is registered inside the blood plasma. The half-life is 86.7 hours; the average retention rate is 127.32 hours.

Dosing and administration

Given the type of pills, they are either taken orally or sucked under the tongue. The serving size is the same for both types. The medication is used in a dosage of 20-50 mg, 2-3 times a day. The portion may increase, sometimes it is brought to 0.2 g per day, although a portion of 0.1 g is considered optimal.

In case of violations of the asthenic, depressive or hypochondrial nature, it is required to use 0.06-0.12 g of the drug per day.

With alcohol withdrawal, 50 mg of drugs are used 3 times a day; the daily portion can be up to 0.5 g.

The therapeutic cycle lasts 1-4 months; a more precise term is personally selected by the attending doctor.

• Application for children

It is forbidden to prescribe in pediatrics.

Use Gidazepam during pregnancy

The medicine should not be used if pregnant or breastfeeding.

Contraindications

The main contraindications:

• severe myasthenia gravis;
• severe renal / hepatic dysfunction;
• severe intolerance to the components of the drug;
• use in the treatment of open-angle glaucoma;
• alcohol-induced liver damage;
• hypolactasia.

Side effects Gidazepam

Among the side signs:

• lethargy, drowsiness, systemic weakness, impaired ability to work and attention, cephalalgia and dizziness;
• nausea, a decrease in blood pressure, a deterioration in the speed of reactions;
• muscle weakness;
• Quincke's edema, allergy symptoms and dermatitis.

Overdose

In case of an overdose of the drug, there are signs characteristic of poisoning with tranquilizers: drowsiness, lethargy, nausea, dizziness, allergies, as well as mild ataxia. To eliminate them, symptomatic procedures are carried out.

Interactions with other drugs

Gidazepam can potentiate the activity of certain drugs, for example, phenamine or 5-hydroxytryptophan. It also potentiates the effects of antipsychotics, alcohol, opioid analgesics and certain hypnotics.

The medication can be combined with some hypnotics, anticonvulsants and psychotropic substances.

Storage conditions

Gidazepam should be kept out of sunlight and small children. Temperature values - no more than 25 ° C.

Shelf life

Gidazepam can be used for a 4-year term from the date of manufacture of the therapeutic drug.

Analogs

The analogues of the drug are Grandaxin and Sibazon with Neurol.