Gexicon

Hexicon is a medicine that has a disinfecting and antiseptic effect. Interacting with cell structures of pathogenic bacteria, the drug disrupts their vital functions, slows the development of microbes and contributes to the death of pathogenic microflora.

Thanks to the use of different medicinal forms in gynecology, it is possible to effectively destroy pathogenic bacteria and perform the prevention of various STDs.

Indications of the gexicon

Suppositories (and in addition, vaginal pills, drug solution, and gel) are used in the following situations:

• for the prevention of various STDs that develop under the influence of a microflora that is sensitive to the effect of the drug;
• elimination of inflammatory processes in the area of female genitalia;
• in the prevention of the occurrence of inflammation or infection in the genital tract in the period before the performance of gynecological operations, abortion, intrauterine examinations, and in addition before childbirth and so on.

Suppositories Geksikon D are used to eliminate gynecological diseases in children.

The solution can additionally be prescribed for the disinfection of various wound lesions of a purulent nature, and also of infected burns. In urological, surgical, and also gynecological practice can be used in the treatment of infections that affect the mucous membranes and the surface of the skin.

In dentistry, the drug is prescribed for rinsing in the treatment of gingivitis, aphthous form of stomatitis, inflammations affecting the periodontal tissue, and in addition terminal sections of the respiratory ducts.

The gel is additionally prescribed for the treatment of inflammation of the dental, gynecological or urological. In addition, it is used to treat infected areas of the skin.

[1]

Release form

Release of the drug occurs as a therapeutic solution, vaginal tablets (volume 16 mg) and suppositories (volume 8 or 16 mg), and in addition to the gel.

[2]

Pharmacodynamics

The active element of the drug is chlorhexidine. It has a powerful disinfecting effect; sensitivity to it shows a large number of microbes, among them gram-positive and -negative bacteria, and in addition herpes simple viruses.

The drug shows activity against pale treponema, gonococci, ureaplasmas, gardnerella with chlamydia, trichomonads with bacteroidids fraigilis and herpesvirus type 2 (HSV-2).

Weak influence of Gexicon on certain strains of pseudomonads and proteas. Resistant to it are bacterial spores, fungi with viruses and acid-resistant bacteria.

Chlorhexidine provides the drug some advantages over other antiseptics and antimicrobial drugs. Among the properties of this component are:

• does not exert a destructive effect on the natural microflora of female genitalia, nor does it affect the vital activity of lactobacilli;
• does not lead to the development of habituation or resistance to its effects in sensitive bacteria (even in the case of multiple use of drugs);
• can be given to nursing mothers, as well as pregnant women;
• retains the activity of the action (albeit in smaller volumes) in the presence of pus or bloody discharge.

The effectiveness of the action of suppositories is also due to the peculiarities of the elements in their composition: polyethylene oxide types 1500 and 400. These components contribute to the uniform distribution of the active element along the mucosa, and in addition to its deeper passage into the tissues.

Along with this, the polyethylene oxide base facilitates the dehydration of pathogenic microbes, as well as the purification of the mucosa from the accumulating products of bacterial activity.

Pharmacokinetics

The medicine is practically not absorbed from the digestive tract, and besides it through the mucous membranes with the skin surface when applied locally. Systemic absorption after the introduction of vaginal tablets is extremely low.

In the case of accidental ingestion of drugs at a rate of 0.3 g, the peak value is observed after a lapse of 30 minutes and equal to 0.206 μg / l.

Elimination of the medication is mainly carried out together with the intestinal contents (90%). Excretion through the kidneys is less than 1% of the substance.

[3], [4], [5], [6]

Dosing and administration

Use of suppositories.

Suppositories are administered by intravaginal method.

For treatment it is required twice a day to administer 1 suppository for 7-10 days. If necessary, this course can be repeated after 20 days.

In the prevention of STDs, 1 suppository must be entered after a maximum of 2 hours after an unprotected sexual contact has occurred.

Suppositories Hexicon D are used in a similar way.

Application of the drug in a helium form.

When eliminating inflammation of the gynecological or urological nature, it is required to treat the affected areas with gel twice a day. The duration of such therapy varies within 7-10 days.

Infections of the dermatological nature must be eliminated by treating the infected areas with a thin layer of gel - the procedure is carried out 2-3 times / day. The duration of such treatment is determined by the clinical picture.

In the treatment of dental diseases, the drug is used in the form of applications - 2-3 times per day. The duration of each procedure is 1-3 minutes. The duration of the entire course is selected taking into account the existing clinical indications.

Method of using a medicinal solution.

The medicine is used topically in the form of irrigation, applications or rinses, as well as externally. When performing the procedure, it is required to treat the infected part of the mucosa or skin with a dose of 5-10 ml of the drug, for a maximum of 3 minutes. This procedure is performed 2-3 times / day (the solution can be treated with a tampon or using an irrigation procedure).

To prevent the development of STDs, a drug is recommended to be used for a maximum of 2 hours from the time of unprotected intercourse.

Using the nozzle, which is equipped with a bottle of solution, the medicine is injected into the urethra or into the vagina. The size of the administered portion for a man is 2-3 ml, and for a woman - 1-2 ml (area of the urethra) and 5-10 ml (vaginal area). At the same time, it is required to hold the nozzle for 2-3 minutes.

In addition, it is necessary to treat the skin with pubic skin along with the inner thighs, as well as the genitals. It is recommended to refrain from urinating for 2 hours after the procedure.

In the case of the inflammatory process that develops in the urethra (also with the development of prostatitis against it), a combined treatment is required, supplemented by injecting the solution into the urethra during a 10-day period (once or twice a day at a dosage of 2-3 ml). It is recommended to perform this procedure in a day.

To eliminate diseases in the mouth area, rinses are required. This procedure should be carried out 3-4 times / day. The portion size of the medicinal product required for the first procedure is 5-10 ml.

Use of vaginal tablets.

Before the introduction of the inside of the vagina, the tablet should be moistened in normal water. The size of the daily portion is determined by the diagnosis and is 1-2 tablets. The duration of the course is 7-10 days.

In the prevention of the appearance of STDs, the Hexicon tablet, like the medicament in the form of a suppository, should be administered a maximum of 2 hours after unprotected sex.

[9], [10],

Use of the gexicon during pregnancy

From existing medicinal forms of the drug during breastfeeding or pregnancy is forbidden to use only vaginal tablets. Vaginal suppositories Gexicon are considered very effective, and also safe for women and fetuses / children.

The use of vaginal pills is only allowed in situations where the possible benefits of using them for a woman are more likely than the risk of fetal consequences.

The medicine in the form of suppositories is very often prescribed for pregnant women to eliminate gynecological pathologies or prevent them. Its safety is due to the fact that the medication is applied topically. The absence of negative consequences is confirmed by many years of experience in the use of the drug.

Due to local effects, the active element of the drug almost does not penetrate into the circulatory system and therefore does not threaten the normal development of the fetus. This allows you to use suppositories at any time of pregnancy.

The drug effectively affects the activity of pathogenic bacteria that cause the development of gynecological diseases, but it does not destroy the natural vaginal microflora.

In the first and second trimesters, these properties make it possible to use a drug to prevent the onset of STDs (including trichomoniasis with chlamydia, and in addition syphilis with gonorrhea, or ureaplasmosis and genital herpes), and at the same time to eliminate colpitis with vaginitis, exo- and endocervicitis, as well as bacterial vaginosis.

At the 3rd trimester (also before delivery), the medication is used to prevent the onset of inflammation and infections immediately during childbirth, as well as after them.

Suppositories are also prescribed to eliminate uterine neck erosion. It is most advisable to use them in situations where ulceration develops because of the activity of bacterial pathogens of STDs or because of gynecological inflammatory diseases.

Often, the hexicon is prescribed to pregnant women to eliminate the bacterial form of vaginosis - while the pathogenic microbes predominate inside the vagina, and the number of lactic acid microorganisms (lactobacilli) is reduced or they are completely absent.

Contraindications

The main contraindication is the presence of intolerance in relation to the elements of the drug.

The solution is forbidden to prescribe for dermatitis.

Side effects of the gexicon

The use of suppositories most often causes the appearance of symptoms of allergy, burning and itching in the vagina. These manifestations do not require special therapy, they disappear on their own, at the end of the treatment course.

Complications from the use of the solution arise only in isolated cases. Usually they appear in the form of an itch, and also signs of an allergy (they disappear after the termination or ending of spent therapy).

In some patients, the solution may cause stickiness of the hands (maximum for 3-5 minutes) or dryness of the skin on the hands, as well as photosensitivity and development of dermatitis. When rinsing the mouth, tartar can be deposited, discoloration of the tooth enamel, and in addition a taste disorder. The same symptoms can also be caused by the drug gel.

[7], [8]

Interactions with other drugs

The effectiveness of the drug is potentiated when combined with ethyl alcohol.

It is forbidden to use the medicine at the same time as intravenously injected drugs, which contain iodine.

External sanitation of the genitals does not affect the tolerability and effectiveness of the suppository, since they are used intravaginally.

The drug is not medicated with anionic type detergents (such as sodium lauryl sulfate, saponins and carboxymethyl cellulose), and in addition with soap. When combined with soap, chlorhexidine is inactivated, so before using the medication it is required to completely wash off the soap residues from the mucous membranes and the skin surface.

The combination of hexicon with drugs from the cationic category is allowed.

[11], [12], [13], [14], [15], [16]

Storage conditions

The hexicon should be kept in a place where moisture does not penetrate, with temperatures not exceeding 25 ° C (candles, solution and tablets) or 20 ° C (gel).

Shelf life

The hexicon is allowed to be used for 2 years from the date of release of the medicament.

Application for children

Suppositories and gel for children should be administered carefully. The most suitable form of the drug for them is the suppository Hexikon D.

[17]

Analogues

Analogues of the drug in its composition (gel and solution) are Amident (local solution), and in addition, Chlorhexidine in the form of a solution based on alcohol, the concentrate from which the treatment solution is made, and also the spray.

The following medicines - the cream of Depantol and Bepanten - have the greatest similarity in the mechanism of medicinal action, and in addition the Cytaleal solution and the concentrate for Lavasept solutions.

Tablets and suppositories of the drug are similar in composition to tablets and suppositories of Chlorhexidine.

Similar to the suppository Gexicon, therapeutic mechanisms have such drugs as Hyposol aerosol, Betadine suppository, Iodoxid and Iodovidone suppositories, and also Trichomonacid tablets, MacMiore (in the form of capsules, suppositories, tablets and cream) and vaginal suppositories containing eucalyline or trichomonacid. This group also includes Vagiflor and Laktozhinal capsules, Povidone-Iodine suppository, Dafnejin cream and Furazolidon drug (in the form of tablets, powder and granules for the preparation of drug suspension).

Reviews

The hexicon receives a fairly large number of reviews regarding its medicinal effect. On the forums there are both positive and negative opinions about the drug. Among the positive properties of drugs:

• the rate of drug exposure and the effectiveness of the drug;
• the possibility of use for prevention;
• ease of use of the drug;
• safety when used by breast-feeding mothers and pregnant women;
• softness of the effect, as well as hypoallergenic properties.

Negative comments on suppositories are usually due to the fact that the inside of the suppository starts to flow out gradually, thereby causing inconvenience, and besides this, with the presence of side symptoms such as burning and itching, as well as the appearance of bloody discharge.

Use of candles during pregnancy.

Suppositories Geksikon according to the patients themselves, as well as doctors are considered very effective and, most importantly, safe for use in pregnancy. Among other things, at the initial terms it can sometimes not be replaced by any other medication.

The drug is used on various terms of pregnancy, and in addition for prevention on the eve of childbirth. Based on various reviews, it can be revealed that some women were helped by the drug, but there are also those who, after a certain period of time, needed repeated therapy.

There is also information about the lack of results after using suppositories and even more about the development of allergies to their use. Some patients complained of the occurrence of vaginal discharge of a pinkish hue (in such cases it is required to consult a doctor).

Some negative comments on the use of Gecikon in pregnant women are associated with the heating of suppositories inside the vagina, which causes them to melt and leak - sometimes it is taken as the passage of water or cork.

To ensure a more comfortable condition, doctors are advised to use daily gaskets or (if necessary) conventional gaskets (used for menses) during therapy with suppository Gecikon.