Galavit

The drug Galavit (analogue - Tamerit) belongs to a group of pharmacological agents intended to stimulate immunity. By activating the body's defenses, Galavit has an anti-inflammatory effect, helping to reduce the intensity of inflammatory processes and eliminate their symptoms.

Indications Galavit

As a means of targeted immunocorrection, the drug Galavit is used in the complex treatment of diseases such as:

• infectious lesions of the gastrointestinal tract, accompanied by intoxication and diarrhea;
• gastric ulcer and duodenal ulcer;
• viral hepatitis B and hepatitis C; herpes (including genital);
• genital warts (genitals, larynx, etc.) caused by the human papillomavirus (HPV);
• respiratory tract infections ( bronchitis, pneumonia, etc.);
• inflammation of the mucous membrane of the mouth and throat, periodontal disease;
• urethritis, urogenital chlamydia, mycoplasmosis, chlamydial prostatitis, endometritis, etc.;
• furunculosis, erysipelas;
• purulent-septic complications after surgery.

Indications for the use of Galavit also include secondary immune deficiency, for example, after radiation therapy for certain oncological diseases.

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Release form

The drug Galavit is available in three forms: tablets (25 mg) for sublingual dissolution, powder for preparation of injection solution (100 mg in one bottle) and rectal suppositories (0.1 g of the drug in one suppository).

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Pharmacodynamics

The therapeutic effect of the drug Galavit is due to the fact that the synthetic low-molecular substance sodium aminodihydrophthalazinedione (5-amino-1,2,3,4-tetrahydrophthalazine-1,4-dione sodium salt) included in its composition normalizes the functional activity and metabolism of blood mononuclear phagocytes (mactophages).

On the one hand, for some time (no more than 6 hours) the increased synthesis of various anti-inflammatory cytokines (specific proteins of immune system cells) by macrophages slows down, as a result of which intoxication and the degree of inflammatory reactions of the body caused by pathogenic microorganisms are reduced.

On the other hand, with weakened immunity, the microbiostatic function of neutrophilic leukocytes is activated: the process of capturing and destroying foreign cells (phagocytosis) is enhanced, and the synthesis of interferons and protective antibodies is accelerated. As a result, the ability to resist various infections (non-specific resistance of the body) is significantly increased.

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Pharmacokinetics

Once in the body, Galavit does not undergo any chemical changes and is excreted by the kidneys with urine. The duration of the therapeutic effect of the drug after a single dose is three days on average.

When using tablets, the half-life of Galavit is about 30 minutes; when administered by injection - 15-30 minutes, after using rectal suppositories - 60-70 minutes.

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Dosing and administration

The dosage and duration of the course of therapy with Galavit are determined by the doctor prescribing this drug and depend on the etiology, pathogenesis and clinical manifestations of a particular disease, as well as on the patient's condition.

Sublingual lozenges are prescribed as one tablet 4 times a day or two tablets twice a day.

To prepare a solution for injection, Galavit powder is dissolved in water for injection or 0.9% sodium chloride (2 ml). The drug is injected into the muscle. The usual dose for infectious diseases (in the acute period) is 200 mg. The dosage is then adjusted and can be reduced until signs of intoxication disappear completely. The maximum number of injections per course of treatment is no more than 25.

When treating chronic inflammations against the background of reduced immunity, the scheme for using Galavit is as follows: 100 mg once every three days or 100 mg once a day for 5 days, after which injections (100 mg) are given once every 2-3 days. The course of therapy is no more than 20 injections.

Galavit in suppository form is usually prescribed 2 rectal suppositories once, then 1 suppository 2 times a day - until the symptoms of inflammation disappear. Then the dose is reduced to one suppository every three days. The total dose of the full course of treatment is no more than 25 suppositories.

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Use Galavit during pregnancy

The use of Galavit during pregnancy and breastfeeding is contraindicated.

Contraindications

A contraindication to the use of this drug is individual hypersensitivity to the substances included in its composition.

Side effects Galavit

There are no reports of any undesirable side effects occurring during treatment with Galavit. However, there is a possibility of individual allergic reactions when using the drug.

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Overdose

There are no reports of overdose with this drug (in all three forms).

Storage conditions

The medicinal product Galavit in the form of suppositories should be stored at a temperature of +5-12°C - in a dry place, protected from light. The optimal storage temperature for the preparation of the powder for solution is +15-25°C.

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Shelf life

The shelf life of the drug in tablet and suppository form is 2 years, in powder form (for the preparation of injection solution) - 4 years.