Gabagamma 100.

Gabagamma 100 is a drug used in the treatment of epilepsy manifestations in the form of seizures, as well as complex neuropathies for adults and children over 12 years of age.

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Indications Gabagamma 100.

Gabagamma 100 is prescribed to patients (children over 12 years old and adults) with epilepsy with paracetamol seizures in complex therapy. Also, indications for use are diabetic neuropathies and postherpetic neuralgia as an analgesic substance. The drug Gabagamma 100 is prescribed by the attending physician. It can be purchased in pharmacies only with a prescription.

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Release form

The drug Gabagamma 100 is available in large cardboard packages. This box may contain 2, 5 or 10 blisters with capsules covered with gelatin. The capsules are painted in white opaque color. Inside the capsules is a white powder, which contains 100 mg of the active substance - gabapentin.

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Pharmacodynamics

The active substance of the drug Gabagamma 100 is similar in structure to the neurotransmitter GABA, but the principle of its mechanism of action is fundamentally different from other drugs that act on GABA receptors. Thanks to the studies, it was found that gabapentin does not have GMACergic properties, and its action consists in binding to the subunits of calcium channels, thereby reducing the flow of calcium ions and thus neutralizing neuropathic pain. Gabapentin also increases the amount of GABA, reduces damage and death of neurons, suppresses the release of monoamine neurotransmitters.

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Pharmacokinetics

The maximum concentration of the drug Gabagamma 100 in the blood plasma is observed after 2-3 hours. Moreover, when using a higher dosage, the ability to absorb gabapentin decreases (at a normal dosage, its absorption is approximately 60%). The elimination of the active substance does not depend on the dosage used and is about 5-7 hours. Eating food (including fatty foods) does not affect the absorption of the drug. Gabapentin is excreted only by the kidneys in a completely unchanged form. In blood plasma, it is contained in a free state. The rate of elimination from blood plasma depends entirely on creatinine clearance. This is why it is necessary to prescribe Gabagamma 100 very carefully to elderly people and people with impaired renal function.

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Dosing and administration

The drug Gabagamma 100 is used internally after or during meals. The drug is taken with a small dosage, gradually moving to a larger dose that will be clinically effective. If the drug needs to be discontinued, this is done in stages over 1-2 weeks.

Use of Gabagamma 100 for neuropathic pain

The initial dosage is usually 900 mg/day. The drug is usually taken in equal doses, three times a day (300 mg each). Start with a single dose and bring it up to the daily dose in three days. If necessary, the dosage is increased up to the maximum possible (3600 mg per day).

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Use of Gabagamma 100 in epileptic seizures

The clinically effective therapeutic dose is from 900 mg to 3600 mg per day. Treatment should be started slowly, increasing the dose daily. The drug is recommended to be taken three times a day. When using it, it should be taken into account that the maximum time interval between doses should not be more than 12 hours (to avoid seizures).

When prescribing to people with impaired renal function, it is necessary to take into account the creatinine clearance rate. If the clearance is below 30 ml/min, Gabagamma 100 is prescribed every other day at a dosage of up to 600 mg per day.

Use Gabagamma 100. during pregnancy

The drug Gabagamma 100 has not been tested on pregnant women, therefore, to avoid a teratogenic effect on the fetus, its use should be discontinued in all trimesters of pregnancy. During lactation, the drug should be taken after consultation with a doctor only in extreme cases, if there are no other options.

Contraindications

The drug Gabagamma 100 is contraindicated in inflammation of the pancreas (acute or chronic), as it gives an increased load on the pancreas, with great caution it is prescribed for any type of renal failure, as well as for mental disorders. Also, a contraindication to taking Gabagamma 100 is intolerance to any component, including lactase deficiency.

Side effects Gabagamma 100.

Like most antiepileptic drugs, Gabagamma 100 has a number of side effects. Some of them are more pronounced, some may be absent. We list the main possible side effects.

Side effects of Gabagamma 100 may include:

• cardiological symptoms such as hypertension (high blood pressure) or low blood pressure, as well as palpitations;
• digestive system in the form of: bloating and abdominal pain, upset stomach, nausea or even vomiting, inflammatory gum disease, inflammation of the pancreas, increased activity of liver enzymes (ALT, AST), functional jaundice;
• musculoskeletal system in the form of: pain in muscles, joints, back;
• neurological symptoms in the form of: spasmodic headaches, dizziness, lethargy, insomnia, anxiety, depression, impaired speech, ataxia, dystonia, increased fatigue;
• hematopoietic system in the form of: thrombocytopenia and leukopenia, as well as bruising after physical impact (purpura);
• respiratory system in the form of: swelling of the nasal passages, cough, difficulty breathing, shortness of breath;
• genitourinary system in the form of: urinary incontinence, impotence, increased likelihood of infectious diseases of the kidneys and bladder;
• sensory organs in the form of: visual impairment and hearing loss;
• allergic reactions on the skin in the form of: itching, rashes, acne, erythema;

Also, Gabagamma 100 affects blood sugar levels, so diabetics need to strictly monitor their levels. When using this medicine, excessive weight gain and changes in the color of tooth enamel are possible.

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Overdose

In case of overdose of Gabagamma 100, symptoms of dizziness, double vision, drowsiness, fainting, liturgical sleep occur. Severe diarrhea may also occur. In cases of overdose, urgent gastric lavage, intake of absorbent drugs (activated carbon, smecta) and symptomatic therapy are performed. In case of acute and chronic renal failure, hemodialysis is prescribed.

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Interactions with other drugs

When Gabagamma 100 was used concomitantly with morphine, a 44% increase in the concentration of gabapentin was observed.

The interaction of Gabagamma 100 with other antiepileptic drugs has not been determined, which allows it to be taken in combination with other drugs.

When using the drug Gabagamma 100 with hormonal oral contraceptives containing the substances ethinyl estradiol and norethindrone, no change in the pharmacokinetics of either class of drugs was observed.

When using Gabagamma 100 with drugs from the antacid group, a 20% decrease in gabapentin absorption was noted.

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Storage conditions

Storage conditions for the antiepileptic drug Gabagamma 100 at temperatures up to +25 and air humidity no more than 75%.

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Special instructions

• when prescribing Gabagamma 100 together with other drugs for stopping epileptic seizures, a false positive result of a laboratory urine test for protein is possible;
• Gabagamma 100 is not effective in absence epilepsy;
• When taking Gabagamma 100, it is recommended to refrain from driving vehicles and operating equipment that requires precise, rapid reactions.

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Shelf life

The shelf life of the antiepileptic drug Gabagamma 100 is 3 years. After the expiration date indicated on the package, the use of the medicine is strictly prohibited.

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