Gabagamma 300

Gabagamma 300 is used to stop the manifestations of epilepsy in the form of seizures, as well as in complex neuropathies. Recommended for adults and children over 12 years of age.

Indications Gabagamma 300

Gabagamma 300 is prescribed by the attending physician to patients (children over 12 years and adults) who have a history of epilepsy with parasitic spasms, as a separate drug, and in complex therapy. Also, indications for use are diabetic neuropathies of various localization and neuralgia after suffering herpes as an analgesic substance. The drug Gababamma 300 is prescribed by a neuropathologist or a therapist. In pharmacies, this drug can be purchased only on prescription.

[1]

Release form

The drug Gababamma 300 is available in gelatin capsules of yellow color. Capsules are enclosed in blisters of 10 pieces in each. In pharmacies, you can find cardboard packages with the number of capsules 20, 50 or 100 pieces (respectively 2.5 or 10 blisters). Capsules contain a white powder in which there is 100 mg of active substance - gabapentin. Of the excipients, there is lactase, which should be taken into account in patients with lactase deficiency.

[2]

Pharmacodynamics

The active substance (gabapentin) of the preparation Gababamma 300 is similar in structure to the neurotransmitter gamma-aminobutyric acid, but the mechanism of its action is completely opposite to the drugs acting on the GABA receptors. A detailed study of the principle of action of the active substance revealed that gabapentin does not have GMACergic properties (unlike other antiepileptics - valproate, barbiturates), and its effect is to bind calcium subunits in this way by reducing the flow of calcium ions and neutralizing neuropathic pain . Also gabapentin increases the amount of gamma amino-butyric acid, reduces damage and death of neurons, suppresses the release of neurotransmitters of the monoamine group.

[3], [4]

Pharmacokinetics

Peak concentrations of the drug Gababamma 300 in blood plasma accounted for 2-3 hours. A decrease in the absorption of gabapentin with increasing dosage was noted (at a typical therapeutic dosage, its absorbability is approximately 60%). The dependence of excretion of the drug Gababamma 300 on the dosage used was not detected and it is approximately 5-7 hours. Excretion of the drug is carried out by the kidneys in a completely unchanged form. Absorption of the active substance gabapentin does not depend on the consumption of food, fats and other types of nutrients. In the human blood, namely plasma, gabapentin is contained in a free state. The rate of removal of the drug from the blood plasma depends on the clearance of creatinine. This is why it is necessary to carefully prescribe the drug Gababammma to 300 people in old age and to persons with chronic or acute failure of kidney function.

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Dosing and administration

Taking the drug Gababamma 300 is prescribed after or during meals with a small amount of liquid. The dosage should be increased in stages within a few days reaching up to therapeutically effective. Abolition or switching to another medicine should also be done gradually, so as not to cause a sharp appearance of seizures.

The use of the drug Gababammma 300 with neuropathic pain

The preparation of Gabagamma 300 is usually taken throughout the day at regular intervals and in equal doses. Therapy starts with a clinically effective dosage of 900 mg per day (1 tablet 3 times a day). If the result is not achieved, the dosage is increased until the disappearance of clinical symptoms, but no more than 3600 mg per day.

[7], [8],

The use of the drug Gababamma 300 with epileptic seizures

With epileptic illness, a clinically effective dose ranges from 900 mg to 3600 per day. The dosage is selected individually. Treatment is also begun gradually, daily increasing the dose. In this case, it must be taken into account that for maximum effectiveness, the drug should be taken with a time interval of no more than 12 hours, in order to avoid the occurrence of seizures.

For the appointment of the drug Gababamma, 300 patients with a deficiency of kidney function should be monitored laboratory level of creatinine. When the clearance is below 30 ml per minute, the drug is prescribed at a minimum dosage of 600 mg per day every other day.

Use Gabagamma 300 during pregnancy

The use of the drug Gababamma 300 during pregnancy and breastfeeding has not been studied, therefore, to avoid negative consequences on the fetus, it is necessary to avoid this drug in women in the situation. When breastfeeding, the medicine should be taken only if it is urgently needed and after consulting a specialist. It is advisable to stop feeding during the treatment.

Contraindications

Since the drug is excreted by the kidneys, it should be used with caution in dialysis, persons with the presence of one kidney, as well as patients with acute inflammatory diseases of the kidneys (pyelonephritis, glomerulonephritis). It is highly not recommended to prescribe the drug for acute pancreatitis. In the presence of intolerance to any component of the drug Gababamma 300 (including lactase deficiency), it should be canceled. The use of medication by patients with severe mental disorders can cause deterioration.

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Side effects Gabagamma 300

The drug Gababamma 300 has a number of side effects that affect virtually all of the body's basic systems that are inherent in most antiepileptic drugs.

Frequent side effects may include blood pressure disorders (increase or decrease), increased heart rate, digestive disorders (diarrhea, constipation, nausea, vomiting), liver pain, jaundice (increased liver enzymes), joint pain, muscle pain, insomnia, nervousness , speech impairment, drowsiness, depression, general weakness, dyspnea, cough, shortness of breath. Also, in general condition, hearing and vision may be reduced. Because of the increased work of the kidneys, the likelihood of inflammatory processes in them is significantly increased, chronic diseases can become aggravated.

At laboratory research of a blood thrombocytopenia or a leukopenia can appear. On the skin may appear purpura, rashes, erythema.

Overdose

When an overdose of Gababamma 300 occurs symptoms of the central nervous system, namely dizziness, bifurcation in the eyes, drowsiness, fainting, liturgical sleep. Also, severe diarrhea can occur. When a dosing occurs, urgent gastric lavage is performed followed by sorbents, namely activated carbon, smectas or enterosgel.

[9],

Interactions with other drugs

If you take the drug Gababamma 300 with morphine simultaneously, then there is an increase in the concentration of the active substance by 44%.

The interaction of the drug Gababamma 300 with other antiepileptic drugs has not been determined, which allows it to be taken in conjunction with other medications.

If you simultaneously take the drug Gababamma 300 with hormonal oral contraceptives that have the substance ethinyl estradiol and norethindrone, a change in the pharmacokinetics has not been detected either one or the second class of drugs.

If you take both the preparation Gababamma 300 with sorbents, then there is a decrease in absorption of gabapentin by 20%.

[10], [11], [12]

Storage conditions

The package contains the following storage conditions for the drug Gababamma 300 at temperatures up to +25 and humidity of air no more than 75%.

[13], [14]

Special instructions

• when combining therapy with the drug Gababamma 300 with other antiepileptic drugs may increase the level of protein in the urine;
• the drug Gababamma 300 is not effective in absence of epilepsy;
• since the drug Gababamma 300 acts on the psychomotor reaction, then during its reception should refrain from driving the car and controlling other vehicles requiring an accurate response.

[15], [16]

Shelf life

It is necessary to strictly observe the storage rules and the expiration date of the drug, after which it is strictly forbidden to apply it. Shelf life is indicated on the package and is not more than 3 years.

[17], [18]