Flemoxine solutab for bronchitis: instructions for use

In order to successfully get rid of bronchitis and prevent it from becoming chronic, it is very important to plan treatment and select medications correctly. If the disease is associated with a bacterial infection, then antibiotics are a must. Often, from a huge range of similar drugs, doctors choose Flemoxin for bronchitis: indeed, Flemoxin is great for treating respiratory diseases.

Treatment of bronchitis with Flemoxin

Flemoxin is prescribed only in cases of confirmed microbial etiology of bronchitis, and the bacteria must be sensitive to the action of the drug.

Flemoxin for bronchitis is appropriate in the following situations:

1. The high temperature does not subside for three days.
2. Symptoms of general intoxication appear.
3. Shortness of breath appears.
4. Test results indicate leukocytosis, with a leukocyte count greater than 12,000/l.
5. A shift in the leukocyte formula to the left is observed.

Most often, doctors recommend Flemoxin treatment for chronic bronchitis, especially for the treatment of the purulent form of the disease.

In case of acute symptoms, Flemoxin is used only after receiving the results of bacterial culture, otherwise the drug may be ineffective and even dangerous.

Indications of Flemoxin for bronchitis

Flemoxin is prescribed not only for bronchitis. The drug is also indicated for other respiratory diseases:

• for infectious and inflammatory lesions of the respiratory tract;
• in case of bronchopneumonia;
• in case of pneumonia;
• in case of lung abscess;
• for chronic respiratory pathologies.

Flemoxin should not be taken "at random"; the doctor must first take a sputum sample to determine the sensitivity of the pathogenic microorganisms to this medication. If the bacteria are sensitive, the drug can be used for treatment.

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Flemoxin for obstructive bronchitis

Flemoxin can also be prescribed for the treatment of obstructive bronchitis, a disease in which the patency of the respiratory tract worsens. This type of bronchitis especially often affects children: the main causes can be a viral infection (flu, adenovirus, rhinovirus, respiratory syncytial virus). There is also a chronic form of the disease, which is typical for adult patients.

If the etiology of obstructive bronchitis is purely viral, then the use of Flemoxin is not indicated. The drug is prescribed when a bacterial component is added - when the discharge becomes purulent.

Antibiotics cannot be used as a preventive method, and this also applies to the drug Flemoxin.

For the treatment of chronic obstructive bronchitis in adults, Flemoxin is also prescribed only if purulent elements appear in the sputum.

Release form

Flemoxin is produced in the form of tablets that are capable of dispersing. The tablets have an oblong configuration, engraving on one side surface and a notch for dosing on the other.

The active component of the drug is amoxicillin in the form of trihydrate. Amoxicillin belongs to the group of antimicrobial agents for general use, to a series of β-lactam antibiotics.

The package contains four blister strips, five tablets in each strip.

Names

Flemoxin is a drug whose main ingredient is Amoxicillin. Amoxicillin is also sold in pharmacies and is a complete analogue of Flemoxin - the only difference is that Flemoxin has a convenient form of release and is more comfortable to give to children. However, there is also a drug such as Amoxicillin-Solutab-Norton, which also has a pleasant fruity taste.

Among other analogues of this medication we can name:

Amoxil, Amofast, B-Mox, Graximol, Gramox, Iramox, Alfamox, Amimox, Zoxicillin, Zimox, Ospamox, Amoxidal, Starmox, Tormoxin, Amoxybiotic, Duomox, Polymoxil, Betalactam, Dedoxil, Hiconcil, etc.

Flemoxin Solutab is probably prescribed most often for bronchitis: it effectively copes with bacterial infection. Improvement is observed already on the second or third day from the start of taking the drug. However, it is impossible to treat with the drug for a long time, as it may cause loss of sensitivity of microbes to the action of the drug, as well as increased growth of resistant flora. During treatment, it is necessary to closely monitor the patient's well-being in order to promptly respond to the appearance of possible side effects.

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Pharmacodynamics

Flemoxin for bronchitis is a representative of bactericidal antibacterial drugs of the penicillin group, with a wide spectrum of action.

Flemoxin exhibits antimicrobial activity against gram (+) and gram (-) bacteria, including streptococci, clostridia, neucheria, staphylococci, listeria, and helicobacter. A slightly lower degree of activity is observed against enterococci, Escherichia coli, Proteus, salmonella, shigella, and cholera vibrio.

The drug does not show activity against bacteria producing β-lactamases, pseudomonads, etc.

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Pharmacokinetics

After oral administration, Flemoxin is quickly absorbed, as it is resistant to the effects of gastric acid. The presence of food does not affect the degree of absorption of the drug. The maximum content of the active ingredient in the serum is detected after 1-2 hours.

When taking 500 mg of the drug, the maximum content is detected after two hours.

Approximately 20% of the active ingredient binds to plasma proteins. The drug is freely distributed in mucous tissues, bones, intraocular fluid and sputum.

The drug content in bile secretions is approximately three times higher than its content in serum.

In amniotic fluid and umbilical cord vessels, the content of Flemoxin can be up to 30% of the content of the drug in the serum of a pregnant patient.

The active ingredient weakly penetrates the blood-brain barrier, but in the presence of an inflammatory process in the membranes of the brain, the content in the cerebrospinal fluid is approximately 20% of the drug level in the serum.

The drug is metabolized in the liver, with the release of inactive metabolic products.

Elimination occurs via the kidneys, with a half-life of one to 1.5 hours.

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Dosing and administration

Flemoxin for bronchitis should be taken orally - in the form of whole tablets or dissolved in water.

The time of taking Flemoxin does not depend on food intake.

The dosage of the drug is determined individually, but the standard treatment regimen for bronchitis with Flemoxin is also of great importance:

• For bronchitis, which is accompanied by mild and moderate symptoms, Flemoxin is used as follows:

1. adults and children over 10 years of age are prescribed 500-750 mg twice a day;
2. children from three years of age are prescribed 375 mg twice a day;
3. Children from the age of 18 are prescribed 250 mg in the morning and evening.

• Duration of taking Flemoxin:

1. in mild cases – from five days to a week;
2. in moderate and severe cases – up to 10 days.

• In severe forms of the disease, the frequency of taking tablets is increased to three times a day.
• For chronic bronchitis the following is prescribed:

1. adults 0.75-3 g three times a day;
2. for pediatric patients – at a rate of 60 mg per kg three times a day.

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Flemoxin for bronchitis in adults

An adult patient can take the Flemoxin tablet whole or dissolve it in water.

• If the patient suffers from mild or moderate bronchitis, then a possible dosage regimen is 500-700 mg twice a day.
• Severe bronchitis should be accompanied by taking 500-700 mg of the drug three times a day.
• Chronic bronchitis requires taking Flemoxin 750 mg every eight hours.

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Flemoxin for bronchitis in children

Flemoxin can be used in children from the age of one year. The drug is quite common in pediatric practice.

Flemoxin is liked by children because of its pleasant fruity taste. In addition, the drug is considered low-toxic and safe for children.

For ease of administration, you can make syrup from the tablet: dissolve the tablet in 20 ml of warm water. If you dissolve the tablet in 100 ml of liquid, you can get a suspension that is easy to give to any baby.

The dosage of Flemoxin in pediatrics is determined by the child's age, body weight and characteristics of bronchitis. On average, the daily amount of the drug can be from 30 to 60 mg / kg: this amount is divided into two or three times.

As a rule, the following treatment regimen is relevant:

• A child aged 1-3 years takes 250 mg of antibiotic twice a day, or 125 mg three times a day.
• A child aged 3-10 years takes 250 mg three times a day.
• A child over 10 years old takes 375 to 500 mg three times a day.

The total duration of therapy with Flemoxin can be 7-10 days, depending on the complexity of the disease.

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Use of Flemoxin for bronchitis during pregnancy

In general, Flemoxin does not have teratogenic activity. However, this antibiotic is prescribed only in case of extreme necessity, preferably in the second half of pregnancy.

Treatment with the drug during breastfeeding is possible, but not desirable, as it may lead to the development of sensitization. Breastfeeding is definitely stopped if the child develops dyspeptic syndrome or skin rash.

Contraindications

Flemoxin is not used for bronchitis if the patient has hypersensitivity to penicillin and cephalosporin drugs, as well as to any auxiliary components of the dosage form.

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Side effects of Flemoxin for bronchitis

During the treatment of bronchitis with Flemoxin, certain side effects may occur:

• fungal diseases, intensive growth of resistant bacteria;
• hemolytic anemia, impaired blood clotting;
• hypersensitivity reactions, serum sickness, vasculitis;
• nausea, vomiting, diarrhea, black "hairy" tongue syndrome, darkening of tooth enamel, inflammatory processes in the intestines;
• dizziness, irritability;
• cholestasis, increased levels of AST and ALT;
• skin rash, vesicular dermatitis, itching;
• crystalluria.

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Overdose

Signs of overdose may include dyspeptic symptoms, such as nausea, vomiting, diarrhea, and, as a consequence, water and electrolyte imbalance. In rare cases, crystalluria may be observed, with subsequent development of renal failure.

In case of an overdose of Flemoxin, it is necessary to induce vomiting or wash out the stomach, take any sorbent preparation and a laxative. To maintain the water-electrolyte state, it is recommended to drink plenty of water.

In severe cases, hemodialysis may be connected.

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Interactions with other drugs

If a doctor prescribes Flemoxin for bronchitis, he must take into account the possible interactions of this antibiotic with other medications:

• The combination of Flemoxin and Amoxicillin may cause an allergy.
• When taking Flemoxin simultaneously with Warfarin or Acenocoumarol, it is necessary to regularly check the prothrombin index.
• Flemoxin may increase the toxicity of Methotrexate.
• During treatment with Flemoxin, blood glucose levels are assessed using non-enzymatic reactions with glucose oxidase. The use of non-enzymatic methods often leads to incorrect results.
• Some drugs may increase the half-life and total serum levels of the drug. These include Probenecid, Aspirin, Sulfinpyrazone, Phenylbutazone, Oxyphenbutazone.
• Flemoxin may affect the absorption and effect of drugs containing estrogens.
• Flemoxin should not be combined with antibiotics such as tetracyclines, macrolides, Chloramphenicol. This recommendation does not apply to aminoglycosides.

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Storage conditions

Flemoxin, which is prescribed for bronchitis, can be stored in normal room conditions, out of reach of children.

Shelf life

The shelf life of Flemoxin is up to five years.

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What is better for bronchitis?

Today, various groups of antibacterial agents can be used to treat bronchitis. These are aminopenicillins, macrolide antibiotics, fluoroquinolone drugs, and cephalosporins.

Flemoxin belongs to the first-line antibiotics – aminopenicillins.

Such medications damage the membrane of the microbial cell, which leads to the death of the bacteria. Pneumococci, streptococci, staphylococci and other bacteria are sensitive to the effects of the drug, which can cause the development of an inflammatory process in the bronchi.

Why do doctors prefer to prescribe aminopenicillins first? The fact is that the human body lacks membrane cell structures that are similar to the cell structures of pathogenic microorganisms. Therefore, by destroying the cell membrane of the pathogen, Flemoxin does not damage other, healthy cells.

Flemoxin is the drug of choice for treating bronchitis, both for adults and children. This antibiotic has only a couple of disadvantages:

• sometimes can cause the development of allergies;
• practically ineffective against microbes that produce the substance β-lactamase.

The enzyme in question has a destructive effect on any penicillin-type drugs. It turns out that it is not the antibiotic that destroys the microbial cells, but the bronchitis pathogen that damages the antibiotic. However, specialists have found a way out: to neutralize β-lactamase, amoxicillin is combined with a clavulanic acid drug. The combination of components increases the antibiotic's resistance and potentiates its fight against microbial cells.

However, a logical question arises: if aminopenicillins are optimal for bronchitis, then which drug is better? After all, there are many drugs known among aminopenicillins: Flemoxin, Amoxiclav, Arlet, Augmentin, etc.

Let's figure it out!

• Flemoxin or Sumamed?

In case of bronchitis, it is better to give preference to Flemoxin, because its active ingredient is amoxicillin, a first-line antibiotic. Sumamed is represented by a second-line antibiotic, azithromycin. Sumamed is best used only in cases where Flemoxin is contraindicated for some reason, or if the patient has recently received treatment with Flemoxin.

In addition, the sensitivity of microorganisms to antibiotics is also taken into account: if the analysis showed resistance to Flemoxin, then the appointment of Sumamed in this case is justified.

• Amoxiclav or Flemoxin?

Both drugs are considered effective, both are produced in a convenient dosage form. However, Amoxiclav is a drug not only of amoxicillin, but also of clavulanic acid. This means that it has a wider spectrum of antibacterial activity: Amoxiclav damages even the cells of bacteria that produce β-lactamases.

In this situation, it is advisable to take Flemoxin only when the patient has hypersensitivity to such a component as clavulanic acid - sometimes this ingredient causes allergies and digestive disorders.

• Flemoxin or Suprax?

The action of Flemoxin and Suprax in bronchitis is almost equivalent. Both drugs are equally effective and relatively safe. If you still have to choose one of the drugs, then it is necessary to take into account the resistance of a particular type of bacteria, as well as previous antibiotic prescriptions for the patient.

For example: if a patient has recently been treated with an antibiotic, then at the moment he needs to be prescribed a fundamentally different drug, with a different active ingredient. In the antibiotic Flemoxin, such an ingredient is amoxicillin, and in Suprax, it is cefixime.

In any case, you cannot choose an antibiotic for treating bronchitis on your own: a doctor should do it. An incorrectly chosen antimicrobial drug can subsequently cause severe complications. If the doctor, after assessing the test results, advises taking Flemoxin for bronchitis, then you can be sure: this antibiotic is effective and will have the necessary effect already within the first 2-3 days of the disease.