Flemoxin solutab for bronchitis: instructions for use

In order to successfully get rid of bronchitis and prevent its transition to a chronic form, it is very important to plan the treatment correctly and choose the medications. If the disease is associated with a bacterial infection, then the appointment of antibiotics - is mandatory. Often, from a huge number of such drugs doctors choose Flemoxin for bronchitis: indeed, Flemoxin is perfectly suitable for the treatment of respiratory diseases.

Treatment of bronchitis with Flemoxin

Flemoxin is prescribed only in cases of confirmed microbial etiology of bronchitis, and the bacteria must necessarily be sensitive to the action of the drug.

Flemoxin in bronchitis is appropriate in such situations:

1. The heat does not drop for three days.
2. There are symptoms of general intoxication.
3. Appears shortness of breath.
4. Analyzes indicate leukocytosis, with a white blood cell count of more than 12,000 / l.
5. There is a shift of the leukocyte formula to the left.

Most often doctors recommend the treatment of Flemoxin in the chronic course of bronchitis - especially for the treatment of a purulent form of the disease.

For acute symptoms Flemoxin is used only after obtaining the results of bacterial inoculation, otherwise the drug may be ineffective and even dangerous.

Indications of the flemoxin in bronchitis

Flemoxin is prescribed not only for bronchitis. The use of the drug is indicated in other respiratory diseases:

• at infekuionno-inflammatory defeats of respiratory ways;
• with bronchopneumonia;
• with pneumonia;
• with abscess of the lung;
• with chronic respiratory pathologies.

Flemoxin can not be taken "at random" beforehand the doctor should take sputum analysis to determine the sensitivity of microorganisms-pathogens to this medication. If the bacteria are sensitive, then the drug can be used for treatment.

[1],

Flemoxin in obstructive bronchitis

Flemoxin can also be prescribed for the treatment of obstructive bronchitis, a disease in which the permeability of the respiratory canal deteriorates. Especially often such bronchitis affects children: the main causes may be a viral infection (influenza, adenovirus, rhinovirus, respiratory syncytial virus). Isolate also the chronic form of the disease, which is typical for adult patients.

If the etiology of obstructive bronchitis is purely viral, then the use of Flemoxin is not indicated. The drug is prescribed when the bacterial component is attached - when the secretions become purulent.

As a preventive method, antibiotics can not be used, and this applies, in particular, to the Flemoxin preparation.

For the treatment of chronic obstructive bronchitis in adults, Flemoxin is also prescribed only in the case of the appearance of elements of pus in the sputum.

Release form

Flemoxin is produced in the form of tablets that are capable of dispersing. Tablets have an elongated configuration, engraving on one side surface and incision for dosing - on the other.

Active component of the drug is amoxicillin in the form of trihydrate. Amoxicillin belongs to the group of general antimicrobial agents, to a number of β-lactam antibiotics.

The package contains four blister plates, five tablets in each plate.

Titles

Flemoxin is a drug whose main ingredient is Amoxicillin. Amoxicillin is also sold in pharmacies and is a complete analogue of Flemoxin - the only difference is that Flemoxin has a convenient form of release and it is more comfortable to give to children. However, there is a drug such as Amoxicillin-Solutab-Norton, which also has a pleasant fruit flavor.

Among other analogues of the given medicine it is possible to name:

Amoxal, Amofast, V-Mox, Graximol, Gramox, Iramox, Alfamox, Amimix, Zoxycillin, Zimox, Ospamox, Amoxidil, Starmox, Tormoxin, Amoxibiotic, Duomox, Polymoxyl, Betalactam, Dedoxyl, Hiconcil and others.

Flemoxin soluteba in bronchitis is, perhaps, most often prescribed: it effectively copes with bacterial infection. Improvement is observed already on the second or third day from the beginning of the drug. However, it can not be treated for a long time, since there may be a loss of microbial sensitivity to the action of the drug, as well as an increase in the growth of resistant flora. During treatment, it is necessary to carefully monitor the patient's state of health in order to respond in a timely manner to the occurrence of possible side effects.

[2]

Pharmacodynamics

Flemoxin in bronchitis is a representative of bactericidal antibacterial drugs of the penicillin group, a wide range of effects.

Flemoxin exhibits antimicrobial activity against gram (+) and gram (-) bacteria, among which are streptococci, clostridia, nejsherii, staphylococcus, listeria, Helicobacteria. A slightly lower degree of activity is observed in relation to enterococci, Escherichia coli, Proteus, Salmonella, Shigella, cholera vibrio.

The drug does not show activity to the bacteria that produce β-lactamase, pseudomonad, etc.

[3]

Pharmacokinetics

After oral administration, Flemoxin is rapidly absorbed, as it has resistance to the effects of gastric acid. The presence of dietary masses does not affect the degree of absorption of the drug. Limit content of the active ingredient in the serum is detected after 1-2 hours.

When taking 500 mg of the drug, the maximum content is detected after two hours.

Approximately 20% of the active ingredient forms a bond with plasma proteins. The drug is freely spread in the mucous tissues, bones, intraocular fluid and sputum.

The content of the drug in the bile secretions is higher than its content in the serum, approximately three times.

In the amniotic fluid and vessels of the umbilical cord, the Flemoxin content may amount to 30% of the content of the drug in the serum of the pregnant patient.

The active ingredient weakly crosses the blood-brain barrier, but in the presence of an inflammatory process in the membranes of the brain, the content in the CSF is approximately 20% of the serum level of the drug.

Metabolism of the drug occurs in the liver, with the release of inactive metabolic products.

Elimination is carried out by the kidneys, with a half-life of one to 1.5 hours.

[4], [5], [6]

Dosing and administration

Flemoxin in bronchitis should be taken orally - in the form of whole tablets, or dissolved in water.

Time of reception Flemoxin does not depend on the use of food.

The dose of the drug is determined on an individual basis, however, the standard scheme of treatment of bronchitis with Flemoxin is of no small importance:

• With bronchitis, which is accompanied by mild and moderately expressed symptoms, Flemoxin is used as follows:

1. adults and children after 10 years are prescribed 500-750 mg twice a day;
2. children from the age of three are prescribed 375 mg twice a day;
3. Children from the heady age are prescribed 250 mg in the morning and in the evening.

• Duration of admission Flemoxin:

1. with easy flow - from five days to a week;
2. with moderate and severe course - up to 10 days.

• With a severe form of the disease, the frequency of taking the tablets is increased to three times a day.
• In the chronic course of bronchitis appoint:

1. adults 0.75-3 g three times a day;
2. patients of childhood - at the rate of 60 mg per kg three times a day.

[12],

Flemoxin in adult bronchitis

An adult patient may take the Flemoxin tablet in its entirety, or dissolve it in water.

• If the patient suffers from bronchitis in mild or moderate form, the possible regimen is 500-700 mg twice a day.
• Severe bronchitis should be accompanied by the intake of 500-700 mg of the drug three times a day.
• Chronic bronchitis means taking Flemoxin 750 mg every eight hours.

[13], [14], [15]

Flemoxin in children with bronchitis

The use of Flemoxin for children is possible from one year of age. The drug is fairly common in children's practice.

Flemoxin is liked by children because of its pleasant fruit flavor. In addition, the drug is considered to be low-toxic and non-hazardous to children.

For convenience of reception from a tablet it is possible to prepare a syrup: a tablet dissolve in 20 ml of warm water. If you dissolve the tablet in 100 ml of liquid, you can get a suspension that is easy to give to any baby.

The dosage of Flemoxin in pediatrics is determined by the child's age, body weight and bronchitis. On average, the daily amount of the drug can be from 30 to 60 mg / kg: this amount is divided into two or three times.

As a rule, such a treatment scheme is topical:

• A child of 1-3 years takes 250 mg of an antibiotic twice a day, or 125 mg three times a day.
• A child 3-10 years old takes 250 mg three times a day.
• A child from 10 years of age takes from 375 to 500 mg three times a day.

The total duration of therapy with Flemoxin may be 7-10 days, which depends on the complexity of the disease.

[16], [17], [18]

Use of the flemoxin in bronchitis during pregnancy

In general, Flemoxin does not have teratogenic activity. However, this antibiotic is prescribed only in case of emergency, preferably in the second half of pregnancy.

Treatment with the drug during breastfeeding is possible, but undesirable, as it can lead to the development of sensitization. Breastfeeding is unequivocally terminated if the child has a dyspeptic syndrome or skin rash.

Contraindications

Flemoxin in bronchitis is not used if the patient is hypersensitive to penicillin and cephalosporin drugs, as well as to any auxiliary components of the dosage form.

[7], [8]

Side effects of the flemoxin in bronchitis

During the treatment of bronchitis with Flemoxin, certain side effects may occur:

• fungal diseases, intensive growth of resistant bacteria;
• hemolytic anemia, deterioration of blood coagulability;
• hypersensitivity reactions, serum sickness, vasculitis;
• nausea, vomiting, diarrhea, black syndrome "hairy" tongue, darkening of tooth enamel, inflammatory processes in the intestine;
• dizziness, irritability;
• cholestasis, elevated levels of AST and ALT;
• skin rash, blistering dermatitis, itching;
• crystalluria.

[9], [10], [11]

Overdose

Signs of overdose can be dyspeptic phenomena - for example, nausea, vomiting, diarrhea, and as a result - a violation of the balance of water and electrolytes. In rare cases, crystalluria can occur, followed by the development of renal failure.

In case of an overdose Flemoxin it is necessary to provoke vomiting or rinse the stomach, take any sorbent preparation and laxative. To support the water-electrolyte state, it is recommended to drink plenty of water.

In severe cases, it is possible to connect hemodialysis.

[19], [20]

Interactions with other drugs

If the doctor prescribes Flemoxin for bronchitis, then he must take into account possible interactions of this antibiotic with other medicines:

• The combination of Flemoxin and Amoxicillin can cause allergies.
• When taking Flemoxin with Warfarin or Ascenocoumarol concomitantly, prothrombin index should be checked regularly.
• Flemoxin may increase the toxicity of Methotrexate.
• During the treatment with Flemoxin, the glucose level in the blood is assessed by non-enzymatic reactions with glucose oxidase. The use of non-enzyme methods often leads to incorrect results.
• Some drugs may increase the half-life and the total content of the drug in the serum. These medicines include Probenecid, Aspirin, Sulfinpirazone, Phenylbutazone, Oxyphenbutazone.
• Flemoxin can affect the absorption and effect of preparations containing estrogens.
• You should not combine Flemoxin with antibiotics such as tetracyclines, macrolides, Chloramphenicol. This recommendation does not apply to aminoglycosides.

[21], [22]

Storage conditions

Flemoxin, which is prescribed for bronchitis, can be stored in ordinary room conditions, away from children.

Shelf life

Duration of storage Flemoxin - up to five years.

[23]

What is better with bronchitis?

To date, various groups of antibacterial agents can be used to treat bronchitis. These are aminopenicillins, macrolide antibiotics, fluoroquinolone drugs, cephalosporins.

Flemoxin refers to first-line antibiotics - aminopenicillins.

Such medications damage the membrane of the microbial cell, which leads to the death of the bacterium. The effects of the drug are sensitive to pneumococci, streptococci, staphylococci and other bacteria that can cause the development of the inflammatory process in the bronchi.

Why do doctors prefer to prescribe aminopenicillins first? The fact is that in the human body there are no membrane cellular structures that have a similarity with the structures of cells of pathogenic microorganisms. Therefore, destroying the cell membrane from the pathogen, Flemoxin does not damage other healthy cells.

Flemoxin is the drug of choice for the treatment of bronchitis, both for adults and for children. This antibiotic has only a couple of drawbacks:

• sometimes it can cause allergy development;
• is practically ineffective relative to the microbes that produce the substance β-lactamase.

The enzyme in question is destructive to any penicillin preparation. It turns out that no antibiotic destroys microbial cells, and the causative agent of bronchitis damages the antibiotic. Nevertheless, the specialists found a way out: to neutralize β-lactamase, amoxicillin is combined with the preparation of clavulanic acid. The combination of components increases the resistance of the antibiotic, and potentiates its fight against microbial cells.

However, a logical question arises: if aminopenicillins are optimal for bronchitis, then which drug is better? In fact among aminopenicillins many preparations are known: Flemoxinum, Amoxiclav, Arlet, Augmentin, etc.

We suggest to understand!

• Flemoxin or Sumamed?

With bronchitis, it is better to give Flemoxin, because its active ingredient is amoxicillin, the first line antibiotic. Sumamed is also represented by an antibiotic of the second line - azithromycin. Sumamed is best used only in cases when Flemoxin for any reason is contraindicated, or if the patient has recently received treatment with Flemoxin.

In addition, the sensitivity of microorganisms to antibiotics is also taken into account: if the analysis showed the presence of resistance to Flemoxin, then the appointment of Sumamed in this case is justified.

• Amoxiclav or Flemoxin?

Both drugs are considered effective, both produced in a convenient dosage form. However, Amoxiclav is a preparation of not only amoxicillin, but also clavulanic acid. This means that it has a broader spectrum of antibacterial activity: Amoxiclav damages even cells of bacteria that produce β-lactamase.

In this situation, you can advise taking Flemoxin only if the patient has an increased sensitivity to a component such as clavulanic acid - sometimes this ingredient causes allergies and digestive disorders.

• Flemoxin or Suprax?

The action of Flemoxin and Suprax in bronchitis is almost the same. Both drugs are equally effective and relatively safe. If you still have to choose one of the drugs, then you must take into account the resistance of a particular variety of bacteria, as well as take into account the previous prescription of antibiotics to the patient.

For example: if not so long ago the patient was treated with any of the antibiotics, at the moment he needs to prescribe a fundamentally different drug, with another active ingredient. In the antibiotic Flemoxin, this ingredient is amoxicillin, and Suprax has cefixime.

Whatever it was, you should not choose an antibiotic for bronchitis treatment yourself: it should be done by a doctor. Incorrectly selected antimicrobial medication can subsequently cause serious complications. If the doctor, after evaluating the results of the tests, advises taking Flemoxin in bronchitis, then one can be sure that this antibiotic is effective and will have the necessary effect within the first 2-3 days of the disease.