Flavamed

Flavamed is a phlegm-thinning and expectorant drug.

The medicine liquefies viscous bronchial secretions and simplifies their passage - improving the processes of mucociliary clearance (movement of mucus that occurs with the help of ciliated cells). Along with this, the drug improves the parameters of external respiratory processes, acting as an expectorant (helps to excrete phlegm), as well as a mucolytic (thinning effect).[1]

Also, the drug increases the volume of surfactant. [2]

Indications Flavamed

It is used in the case of chronic or active forms of pathologies of the respiratory organs, in which the presence of viscous, difficult to excrete sputum is noted:

• bronchiectasis or bronchitis;
• tracheitis, sinusitis, pharyngitis or laryngitis ;
• pneumonia;
• runny nose;
• pulmonary cystic fibrosis ;
• BA;
• RDS syndrome;
• prevention or therapy of postoperative lung complications;
• during preparation for bronchoscopy.

Release form

The release of the drug substance is made in the form of tablets with a volume of 30 mg.

It is also sold in the form of an oral solution, inside bottles with a capacity of 60 or 100 ml; inside the pack - 1 such bottle and a measuring spoon.

Pharmacodynamics

The active element of the drug is ambroxol hydrochloride. It enhances the excretory activity of the glands of the respiratory tract. Ambroxol potentiates the excretion of the surfactant of the lungs, directly affecting the type 2 pneumocytes inside the alveoli and the Clara cells located inside the bronchioles; in addition, it has a stimulating effect on ciliary activity. The result is increased mucus secretion and improved mucociliary clearance.

When the processes of fluid release are activated and mucociliary clearance is increased, mucus excretion is facilitated and cough is weakened. [3]

The drug effect develops after half an hour from the moment of taking the drug and lasts within 6-12 hours (depending on the portion size).

Ambroxol hydrochloride has anti-inflammatory effects in vitro. During in vitro tests, it was found that the component significantly reduces the blood release of the cytokine, as well as the tissue synthesis of poly- and mononuclear cells.

The use of the substance increases the indicators of antibiotics (cefuroxime and amoxicillin with erythromycin) inside sputum and bronchopulmonary secretions.

Pharmacokinetics

Suction.

The absorption of the drug is quite complete and occurs at high speed; the process has a linear relationship when used in the drug range. Plasma Cmax values are noted after 1-3 hours from the moment of application.

Distribution processes.

The component is rapidly and rapidly distributed from the blood into the tissues; high values are noted inside the lungs. The indicator of the distribution volume after ingestion is 552 liters. Inside the blood plasma in the drug range, about 90% of the drug is synthesized with blood protein.

Metabolic processes and excretion.

About 30% of the dosage after oral administration is excreted by a presystemic metabolic process. Ambroxol is involved in intrahepatic metabolism through glucuronidation and degradation within dibromantranilic acid (about 10% of the serving). Clinical testing with hepatic microsomes revealed that the process described above proceeds with the help of CYP3A4.

Over a 3-day period, approximately 6% of the dosage is excreted unchanged; another 26% of the portion - together with urine in the form of conjugates.

The term plasma half-life is within 7-12 hours. Total clearance values are approximately 660 ml per minute. Renal clearance rates are about 83% of the total values.

Dosing and administration

Use of pills.

The tablets should be taken orally after meals. The dosage is 30 mg, taken 2-3 times per day. In case of exacerbation of the chronic form of pathology, the portion can be increased to 60 mg, 2 times a day.

The size of the children's dosage is selected, taking into account the weight - at 1.2-1.6 mg / kg per day (in 3 doses).

The duration of the medication is not limited, but long-term treatment should be carried out exclusively under the supervision of a physician. Without prior medical advice, Flavamed can be used for a maximum of 4-5 days.

Application of the solution.

Children under 2 years of age.

0.5 scoops of oral liquid (2.5 ml), 2 times per day - corresponds to 15 mg of ambroxol per day.

Age within 2-5 years.

0.5 scoop of medication 3 times per day - corresponds to 22.5 mg of medication per day.

Age category 6-12 years old.

For 1 scoop (5 ml) of the drug, 2-3 times a day - corresponds to 30-45 mg of drugs per day.

Children over 12 and adults.

2 scoops of the drug (10 ml), 3 times per day - corresponds to 90 mg of the substance per day (this scheme is used in the first 2-3 days). Further, the medication is taken in the same dosage, but 2 times per day - it corresponds to 60 mg of ambroxol per day.

If necessary, the adult dosage can be increased to 2-fold intake of 20 ml of the drug per day (corresponds to a daily portion of 0.12 g of ambroxol hydrochloride).

The solution can be consumed without reference to food intake. It is forbidden to use Flavamed for more than 4-5 days without consulting a doctor.

• Application for children

The medication in tablets should not be used in persons under the age of 6.

Use Flavamed during pregnancy

The active molecules can cross the placenta, but no negative effects on embryonic / fetal development, as well as the course of pregnancy and childbirth, have been noted in animal tests. The use of drugs in pregnant women should be done with extreme caution.

Ambroxol hydrochloride is excreted in breast milk. Flavamed should not be prescribed for hepatitis B, although a negative effect is not expected.

Contraindications

The main contraindications:

• severe renal / hepatic dysfunction;
• hypersensitivity to the elements of the medication.

The medicine is carefully used in people with an ulcer or erosion in the gastrointestinal tract, and besides this, when using antitussive medications.

Side effects Flavamed

Among the side effects:

• digestive disorders: constipation, nausea, dry mouth, diarrhea, heartburn and gastralgia;
• allergy symptoms: Quincke's edema, epidermal rash, urticaria, itching and anaphylactic symptoms (including shock);
• others: headaches and weakness.

Overdose

Overdose signs: stool disorders (diarrhea or constipation), nausea and other manifestations of dyspepsia.

It is necessary in the period of the first few hours after the use of drugs to perform gastric lavage or induce vomiting; in addition, symptomatic procedures are carried out.

Interactions with other drugs

When the medication is used together with medicines that suppress coughs, excessive accumulation of mucus associated with suppression of the cough reflex is possible. Because of this, such a combination can only be used after a medical assessment of all possible risks and benefits.

Storage conditions

Flavamed should be kept out of the reach of small children. Temperature values are in the range of 15-25 ° С.

Shelf life

Flavamed can be used for a 2-year term from the date of manufacture of the drug.

Analogs

The analogs of the drug are the substances Ambroxol, Lazolvan, Ambrobene with Abrol and Bronchoval.