With intramuscular injection, the drug is absorbed gradually. The maximum amount of active component is detected only after a week. The use of Fazlodex at a dosage of 0.5 g provides optimal balance during the first 4 weeks of use. Equilibrium provides for fluctuating the level of the active substance in the plasma in a fairly narrow range: the readings max and min can differ approximately 3-fold.
With intramuscular injection, the ratio can be proportional to the administered dosage of the drug (in the range of 0.05-0.5 g).
The active substance is distributed in the body fairly quickly, and mainly outside the vessels. With plasma proteins binds to 99%. The main components of the ligament consist of low-density lipoprotein, medium-density and high-density fractions.
The metabolic properties of the active substance of the drug consist of a combination of a large number of possible methods of biological transformation, identical to the metabolic schemes of endogenous steroid hormones. Defined metabolites may be somewhat more passive than the active substance.
The active component of the drug is mostly excreted with calories, about 1% can be excreted through the kidneys. The clearance of the substance implies a high degree of extraction in the liver. The term half-elimination is determined by 50 days.
Pharmacokinetics Fazlodex does not change depending on the age category of the patient, on his weight and belonging to a particular race.