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Fareston
Fareston is an antiestrogenic drug that is used as a hormone therapy. Encoding ATC: L02B A02.
Indications of the fareston
Fareston is used as a topical drug in the treatment protocol for metastatic breast cancer in the mammary gland in the postmenopausal period.
In addition, the drug can be prescribed for preventive and therapeutic purposes with dyshormonal dysplasia of the breast.
Fareston is not used for the treatment of estrogen receptor-negative neoplasms.
Release form
Fareston is released in tablets of 20 or 60 mg. Tablets are flat-rounded, light shade, with one-sided inscription TO 20 or TO 60 (which corresponds to the dosage of the drug).
The active ingredient of Fareston is toremifene citrate.
Tablets are packed in bottles of 30 pcs. Pack of cardboard, with instructions for use inside.
Pharmacodynamics
The active ingredient toremifene is a representative of triphenylethylene and has the property of contacting with estrogen receptors and producing a similar or anti-estrogenic effect. At the same time, a slight decrease in the serum cholesterol level is observed.
Fareston forms a bond with estrogen receptors and blocks the indirect activation of DNA production and the process of cell replication. Studies have confirmed the estrogen-independent anti-cancer effect of the drug.
It is assumed that at the moment, not all the links of the anti-cancer effect of Fareston have been studied. Probably, treatment with a drug provokes changes in oncogenic expression, affects the kinetic properties of the cell cycle, etc.
Pharmacokinetics
Fareston is well absorbed in the body. The limiting level of the active ingredient in the blood serum is determined after 2-5 hours. The presence of food masses in the stomach does not affect the absorption of the drug, but the limit level can be shifted by 90-120 minutes, although this fact has no therapeutic value.
The connection with plasma proteins is noted at 99.5%.
The metabolism of the active ingredient is quite intense. Excretion from the body takes place in the form of residual products with caloric masses, and only up to 10% is excreted by the kidneys.
The stable level of the drug in the blood is noted for about 5 weeks.
Contraindications
Absolute contraindication to the reception of Fareston is considered endometrial hyperplasia and insufficient liver function.
In addition, Fareston is not appointed:
- with a possible allergy to the drug;
- with cardiac pathologies accompanied by an elongation of the QT interval;
- in disorders of water balance with incorrect hypokalemia;
- with severe bradycardia;
- with cardiac pathologies, which are accompanied by a decrease in left ventricular ejection;
- with symptomatic heart rhythm disturbances.
Side effects of the fareston
Adverse reactions when taking Fareston are not uncommon. The following symptoms may occur:
- sensation of "hot flashes", which are accompanied by sweating and redness of the face;
- bleeding and discharge from the vagina;
- feeling tired;
- nausea, dizziness;
- swelling, weight gain;
- thrombosis, thrombophlebitis;
- skin rashes;
- depressive conditions;
- hypertrophy of the endometrium, hyperplasia, polyps, cancerous growths.
Dosing and administration
Phareston is taken orally, at any time, without communication with food intake.
- For dyshormonal dysplasia of the breast, 20 g of preparation per day are prescribed.
- With estrogen-dependent breast cancer, 60 mg per day is prescribed.
- With insufficient kidney function, dosage adjustment is not required.
- With insufficient liver function, Fareston is prescribed very carefully, and the dosage is selected individually.
Interactions with other drugs
It is forbidden simultaneous reception of Phareston and the following medicines:
- antiarrhythmic drugs;
- antipsychotics;
- Erythromycin, moxifloxacin, antimalarial drugs, Pentamidine;
- antihistamines Terfenadine or Misolastine;
- Difemannil, Vinkamina and other medications that can prolong the QT interval.
In addition, other combinations of Fareston should be avoided:
- with thiazide diuretics (due to the development of hypercalcemia);
- with Phenobarbital, carbamazepine (due to the probability of a decrease in the level of toremifene in the bloodstream);
- with antiestrogens and anticoagulants (because of the possibility of bleeding);
- with ketoconazole, antimycotics, macrolide antibiotics (due to inhibition of the metabolic processes of toremifene).