Evinopon

Evinopon belongs to the group of anti-inflammatory and antirheumatic drugs.

Advantages of diclofenac, as well as other non-steroidal anti-inflammatory drugs, consist in the rapid cessation of pain and inflammation, especially with diseases of the movement organs, intolerable joint pains in arthritis and arthrosis. It blocks the formation of mediators of pain - prostaglandins.

The composition of NSAIDs may or may not include acids. Depending on this, they are divided into acids and non-acid derivatives. The acids include salicipates (for example, aspirin), pyrazolidines, diclofenac are referred to as phenylacetic acid derivatives, oxicams (for example, piroxicam), prolyonic acid derivatives (ketoprofen, ibuprofen). Non-acid derivatives include sulfonamide derivatives, as well as alkanones.

I must say that with diclofenac today funds from other groups compete, but it is the most affordable. Oksikam though have a long (up to 12 hours) analgesic effect, many patients at a price are not available. The defeat of joints often affects elderly patients, so diclofenac, despite side effects, is chosen by them because of the low price. Increase the dose to elderly people gradually, relatives should be familiar with the instructions to the drug, be aware of the side effects. If you drink diclofenac in tablets, drink it with plenty of water. Other drinks can not be used. Do not drink alcohol during the treatment for shaking the stomach. If you used to suffer from gastritis or colitis, Evinopon does not suit you for treatment. Moreover, preparations with diclofenac should not be prescribed with an active stage of gastritis, ulcers or colitis.

An alternative to diclofenac in the treatment of arthritis and arthrosis may be Ketoprofen in the form of tablets, solution, aerosol or Nimesulide. The last generation means Movalis - his doctors appoint, if necessary, a very long, for several years, treatment. Movalis is released in the form of candles, a solution for injections, ointments, tablets. Do not forget in arthritis and arthrosis not only to take anti-inflammatory diseases, but also to influence the cause of the disease with chondroprotectors. If you drink diclofenac from a headache, you should also find out its cause, and then get treated.

Another group of new-generation drugs of interest to patients with arthritis and arthrosis is improved drugs with an increased half-life and a minimum of side effects - oxicams. The effect of these drugs is longer than that of diclofenac preparations, so there is no need to take them more than 1 time per day. Anesthesia lasts 12-14 hours. But again, these medicines only relieve inflammation, but do not act on the cartilage. Rheumatoid arthritis and osteoarthritis, unfortunately, remain one of the main causes of pain for a modern person. The problem requires a comprehensive solution, it is necessary to eliminate the cause, and not to dull the pain. Pain, of course, is the most painful sign of any illness. Often insufficiently effective therapy against pain pushes people to use dietary supplements - highly questionable drugs that official medicine does not classify as drugs, or even refer to alternative healers, among which are actually helping people a unit.

The doctor evaluates the safety of NSAID therapy by such criteria as the risk of developing gastropathy and dyspepsia, as well as cardiovascular complications. It is important to clearly assess the possible risks, especially those related to the effect of NSAIDs on the heart and blood vessels. The safety of NSAIDs is assessed in the course of clinical trials and long-term follow-up of a large number of patients. The maximum risk of life-threatening gastrointestinal complications with the drug Evinopon is not related. During the tests and experience of use it was found out that most often such complications arose when Ketoprofen was prescribed. At the same time, it turned out that aceclofenac causes side effects even less often than diclofenac. To minimize the occurrence of bleeding in the stomach and intestines in patients at risk, the doctor may prescribe celecoxib instead of diclofenac drugs. In patients taking this drug, the incidence of endoscopic ulcers is significantly lower. A clinical study in which patients underwent endoscopy before and after treatment with the drug confirmed that celecoxib is optimal for use in patients at risk. It is several times less likely to cause stomach ulcers, gastric and intestinal bleeding than diclofenac. During the clinical trial, it was proved that, in the treatment with celecoxib, relapses of gastrointestinal ulcers occur less frequently than with the appointment of a patient with diclofenac under the guise of a gastroprotector. When the risk of developing gastropathy is extremely high, the doctor may prescribe a gastroprotector and in the treatment with celecoxib. But still such a need arises extremely rarely.

Attention should also be paid to other side effects of NSAIDs: aseptic meningitis, depression, hearing loss and vision. Separately, we pay attention to the fact that Evinopon and other diclofenac preparations with all their shortcomings extremely rarely harm the liver. What can not be said about ubiquitously used paracetamol. The tablet forms of diclofenac are more aggressive towards the liver. The issue of the safety of NSAIDs for the liver in its time caused a wide discussion in scientific medical circles. To date, it can be argued that any drug gives the liver a load, especially if it is taken long in the form of tablets and capsules. In order to protect the liver in situations of extreme vulnerability, with a history of history, diclofenac should be chosen in the form of injections or droppers. Diclofenac may increase the level of transaminases in the blood, but during clinical trials of the drug there were no cases of an increased risk of serious liver damage and related complications. Patients never needed hospitalization or any additional help. Dangerous adverse reactions from the liver with the use of the drug Evinopon can be observed only in cases of patient's non-compliance with recommendations for drug compatibility. And also, if the patient has ignored the doctor's recommendation not to drink alcohol during treatment. Side effects when taking several NSAIDs are often combined. Therefore, it is so important to be aware of the harmful nature of self-medication.

In the hands of a specialist, Evinopon, oxicams and other NSAIDs are convenient tools to improve the quality of life. They are widely used not only to anesthetize and relieve inflammation in orthopedic practice, but also for neurological pathology and oncology for relieving intolerable pain in cancer patients. Before the advent of NSAIDs, doctors were forced to prescribe narcotic drugs. They quickly become addictive, which is not typical for NSAIDs. These drugs are safe when taken correctly. If you take into account the characteristics of the patient, the risk of development of erosion and gastric bleeding is minimal. Advantage of Evinopon - in its form of release. Due to the fact that it is administered in the form of injections or droppers, its effect is more powerful in comparison with tablets and ointments of diclofenac. In our country it has become a common practice to prescribe NSAIDs in the form of intramuscular and intravenous injections for a short time, and then switch to tablets and ointments.

Evinopon for injections does not contain steroids, but acts on the formation of prostaglandins, removing signs of inflammation. He struggles with pain almost as effectively as narcotic painkillers.

Indications Evinopon

Evinopon is indicated for osteoarthritis, arthrosis, spondylarthrosis, bursitis, muscle damage, tendons and ligament apparatus, bruises, gout, radiculitis, spondylitis.

Release form

Evinopon is available as a solution for injections.

Dosing and administration

Method of administration of the drug Evinopon - intramuscular, intravenous and drip. It is necessary to separate the ampoule from the block and shake it. Slowly squeeze the ampoule and roll the head. Connect the syringe to the ampoule and draw the contents of the ampoule into it. Put the needle on the syringe and inject into the upper outer square of the buttocks. The adult dose for severe pain, as a rule, is 75 mg 1-2 times a day. The maximum daily dose is 150 mg. To prevent pain syndrome after surgery, a shock dose of 25 mg for 15-60 minutes is administered. Further, the rate of administration is 5 mg / hr until the maximum possible dose is 150 mg.

Diclofenac can not be taken in any form for long. Evinopon in the form of injections is prescribed for 3-4 days, then go on to use other dosage forms. 

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Use Evinopon during pregnancy

Evinoponum during pregnancy and lactation is prohibited. There is evidence of premature closure of the Botallus duct in newborns, kidney complications in the fetus, and premature birth associated with diclofenac. Evinopon can be replaced with paracetamol, however, it is necessary to strictly adhere to the dosage, since its poor effect on liver function is known. Application Evinopon in the first trimester of pregnancy increases the risk of miscarriage. Therefore, doctors do not recommend pregnant Evinopon.

Contraindications

Evinopon should not be taken if there is sensitivity to diclofenac, ibuprofen or ancillary components of Evinopon, in gastric or intestinal ulcer in the acute stage, in cerebral hemorrhages, cardiac, renal, hepatic insufficiency and urticaria, Crohn's disease, cirrhosis, ascites, blood and violation of hemostasis, at the age of 18 years.

Side effects Evinopon

There were changes in the blood picture (hemolytic anemia, simple anemia) and the psyche of patients: patients sometimes had nightmares, depression and depression, drowsiness, memory impairment, anxiety, dizziness, visual impairment, convulsions, tachycardia, impaired taste, reversible hearing impairment , memory, tremor. There was a report of a stroke associated with taking Evinopon. Patients noted ringing in the ears and chest pain, there were cases of vasculitis, as well as myocardial infarction and hypertensive crisis. On the part of the gastrointestinal tract most often occurs vomiting, flatulence, dyspepsia, diarrhea, anorexia, gastritis, gastric bleeding, colitis, intestinal perforation, stomatitis, pancreatitis. Sometimes spasms in the abdomen, melena and diarrhea with blood developed. On the part of the excretory organs, hematuria, proteinuria, renal necrosis, nephrotic syndrome were noted. On the part of the respiratory system: asthma, allergic pneumonia, respiratory failure. From the liver - hepatitis. The skin can be urticaria, eczema, purpura, erythema, rash, itchy skin, alopecia, sensitivity to light. Possible pain, necrosis of fatty tissue and edema at the site of injection, swelling of the face, a sharp drop in blood pressure (manifestations of an allergic reaction, requiring emergency care). In patients with autoimmune diseases, fever and aseptic meningitis sometimes occur. 

Overdose

Treatment is symptomatic. If necessary, constant monitoring of vital signs is necessary. Symptoms of drug overdose Evinopon: headache, arterial hypertension, respiratory depression, loss of consciousness, abdominal pain, vomiting, impaired liver and kidney function.

Interactions with other drugs

Evinopon helps increase the concentration of lithium and digoxin in the plasma, increasing their toxicity. Reduces the effectiveness of diuretines. Does not affect the action of preoral gipoglikemicheskih drugs. Aspirin reduces the concentration of Evinopon in the blood. Evinopon increases the toxicity of cyclosporine. Colestipol reduces the absorption of diclofenac by one-third. Rifampicin and fentoin reduce the concentration of diclofenac in plasma. With simultaneous administration with quinoline derivatives, convulsions were noted. Do not combine diclofenac with other NSAIDs. Diclofenac has the property of delaying sodium and fluid in the body. Medication that blocks tubular secretion increases the toxicity of diclofenac. Evinoponum weakens the action of some sleeping pills. 

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Storage conditions

Store Evinopon at room temperature, avoiding direct sunlight, out of reach of children.

Shelf life

Shelf life 5 years.