Evista

Evista inhibits bone resorption in women during menopause and acts on the course of the cycle of osteogenesis (formation of bone tissue). It was launched on the market in 1997. It has been used in 50 countries for a long time, but it has spread to us recently. Synonyms - ketidine, bonmax.

And do you know that in order to activate bone formation, besides taking medications that affect estrogen receptors, you need to take fluoride supplements? We all know that fluoride is contained in toothpaste. It strengthens the teeth. But recent developments of scientists convincingly prove also its beneficial effect on the spine: the frequency of vertebral fractures in women in postmenopausal women decreased by 70% due to the intake of fluoride preparations. To stimulate the formation of bone tissue prescribed sodium fluoride.

Evista has one serious side effect - thrombosis. It was manifested in 2% of women taking the drug. 15% had hot flashes, 8% had seizures. If you notice these symptoms in yourself, tell the doctor about it, it may be enough to reduce the dose so that they go away. Before you start taking the drug, tell your doctor about your current or past chronic illness: heart disease, liver, stroke, breast cancer, kidney. During treatment, prolonged immobility should be avoided so that thrombi do not form.

The role of exercise to maintain bone density is enormous: the more active the bones are stimulated by the muscles, the more dense they are.

Estrogen stimulates the production of vitamin D and retains calcium in the body. To produce vitamin D, without which calcium is not absorbed, you need to visit the sun more often. Sunlight helps to synthesize it. The daily intake of calcium is 1200-1500 mg. The norm is divided into two or three methods.

In osteoporosis, especially the spinal fractures should be feared. Be very careful in ice. At a young age, calcium and phosphorus are used to build bone tissue. By the age of 25, growth is coming to an end. Bone mass begins to lose density. Therefore, it is important to have strong bones by the age of the end of growth.

With a body weight of less than 53 kg, the risk of developing osteoporosis is increased. Also, the risk is increased in those who do not consume enough calcium throughout their lives. For example, those who do not like or do not tolerate dairy products. A certain role is played by childlessness or, on the contrary, large families, prolonged breastfeeding, the presence of osteoporosis in relatives, lack of sun, low physical activity, emotional stress, reduction in muscle mass, dysfunction of the ovaries. In old age, thin women of low stature often get hip fractures after which they no longer stand on their feet. A certain role is also played by diabetes and surgery, after which the woman lies for a long time. It is necessary to pay attention to its first signs. As a rule, osteoporosis manifests itself as unexpressed pain in the lower back, the hip joint, the knee, which increase as the disease progresses.

Elderly people reduce their motor activity, they have a diameter of blood vessels, plasma concentration of calcitonin decreases. To stop the progression of the disease, the doctor can prescribe calcitonin, derived from salmon bones. Reception of calcitonin preparations is long, about 6 years.

After menopause, a shortage of progesterone and then estrogen is first detected. Estrogens - regulators of bone resorption. They suppress resorption, reducing the activity of osteoclasts. After menopause, the decrease in bone mass is on average 3%. To osteoporosis at a younger age, sometimes leads to an excessive amount of estrogen in the blood.  

In Germany, in addition to the drug Evist, Osteohin - extract from the leaves of the fern, which, like Evista, also acts on the estrogen receptors in the bones, was widely spread. Of course, hormone replacement therapy is still being carried out.

With the drug Evista, you are not afraid of fractures in postmenopause - you can keep active for a long time without fear for your bones.

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Indications Evista

Beginning osteoporosis in women during menopause. In the complex therapy of uterine cancer. Can be used in men for the treatment of gynecomastia, prostate cancer. Can be used to suppress the side effects of steroid drugs.

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Release form

Coated tablet. In the package 14, 28 or 84 pcs.

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Pharmacodynamics

The active substance of Evista is raloxifene, a representative of the second generation of aromatase inhibitors. It acts as an antagonist of estrogen. It stimulates the production of testosterone. Evista increases the mass of bone tissue, helps reduce total cholesterol, serum fibrinogen. It does not stimulate the tissues of the mammary glands, but prevents the development of their cancer, reduces swelling and manifestations of mastopathy. Acts as an estrogen receptor modulator. Selectively attacks estrogen-sensitive membranes. Increases globulins, binding sex hormones, thyroxine, corticosteroids. 

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Pharmacokinetics

Evista is absorbed after taking 60%. Absolute availability is about 2%. In patients with impaired liver function there is an increase in the concentration of the active substance in the blood plasma. Has a large volume of distribution. The way of elimination is through the intestine, only 6% of the drug can be found in the urine. 

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Dosing and administration

Evista is taken 1 time 1 tablet at any time of the day. Take the drug can be a long time, including. Together with calcium supplements. This will ensure the optimal effect. 

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Use Evista during pregnancy

As a rule, Evista is prescribed to women who are already out of their childbearing age. But nevertheless, if during pregnancy you took Evista, inform the doctor about it. If you want to keep a pregnancy, you need to conduct a thorough screening of the intrauterine pathology in the child. 

Contraindications

Evista is contraindicated in thromboembolism.

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Side effects Evista

Sometimes there is malaise, sweating, depression, nausea, vomiting, diarrhea, weight gain, chest pain, vaginal bleeding, thromboembolism, partial loss of vision, stroke, ischemic attack and stomach ulcer. 

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Overdose

Cases of an overdose of Evista are not described.

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Interactions with other drugs

Simultaneous reception with ampicillin increases the maximum concentration of the drug in the blood. If you have an operation, 96 hours before it should stop taking Evista. The surgeon should know about what medicines you took shortly before the operation. Evista influences blood coagulability. 

[27]

Storage conditions

You can not freeze. Keep Evista's pill from children.

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Shelf life

Shelf life - 2 years.

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