Local remedies for candidiasis
Treatment of candidiasis with local antifungal agents has its pros and cons. Since these drugs do not actually enter the body when applied to the skin and mucous membranes, the side effects from their use are incomparable with the side effects of oral tablets. Usually they are limited to local allergic reactions in the form of redness, itching or burning in the area of application.
Another advantage of using these tools is their speed. The main symptoms of thrush, such as itching and curdled discharge, are already gone since the first days of using local remedies. However, to completely destroy the fungus in order to avoid remission, doctors recommend a full course of treatment, which is usually not less than 10 days.
To the pluses of local drugs can be attributed and the universality of these funds. For example, sprays, ointments and candidiasis creams are great for women with this problem, as well as for men who are also susceptible to this disease, and are often carriers because of their sexual needs.
To the disadvantages of local remedies in the form of creams, ointments and suppositories can be attributed to unsightly tracks that they leave on their underwear. The same applies to female vaginal tablets from candidiasis.
But the main disadvantage of local remedies is their insufficient effectiveness in severe forms of candidiasis. If the mild form of the disease is largely completely cured after a two-week use of local remedies, then a severe form with a tendency to relapse requires complex treatment with generic drugs.
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Vaginal tablets against candidiasis
Women in this regard are lucky, because taking into account the special structure of female genital organs, the pharmaceutical science has developed and released into production a number of special tablets of a convenient oblong form for insertion into the vagina in the framework of antifungal therapy.
These tablets from candidiasis have the following indications for use :
- Light forms of genital candidiasis in women
- Prophylaxis of candidiasis
- In the complex therapy of severe forms of thrush.
The method of using vaginal tablets is quite simple: a slightly water-soaked tablet is injected into the vagina by means of an applicator or fingertip, and the doses of such tablets from candidiasis range from 100 to 500 mg, depending on the active ingredient. Usually it is 1 tablet, which is inserted into the vagina before bedtime.
Features of the use of vaginal tablets:
- During treatment with these drugs, any sexual contact is excluded.
- During menstruation, the drug is temporarily discontinued.
- The use of tablets against candidiasis during pregnancy implies strict adherence to the instructions of a gynecologist because some vaginal tablets can cause various disorders during pregnancy and fetal development.
- The possibility of using vaginal tablets and suppositories during breastfeeding is also worth consulting with a doctor.
Vaginal tablets can be divided into several groups, based on the active substance with an antifungal effect:
- Introconazole - tablets "Irunin", suppository "Introconazole".
- Clotrimazole - tablets "Kanizon", "Candid", "Kandibene", "Kandizol", and actually itself "Clotrimazole" in tableted form.
- Miconazole - tablets "Klion-D 100", suppository "Ginezol".
- Nystatin - tablets "Terzhinan", "Giterna", "Polizhinaks", "Nystatin".
- Ketoconazole - tablets (suppositories) "Livarol".
- Levorin - tablets "Levorin".
Pharmacodynamics of these drugs is that the active substances of vaginal tablets, released into the vagina, adversely affect the cellular level on fungi of the genus Candida, causing their weakening and death, thereby preventing the spread of fungal infection.
Pharmacokinetics. Local application of vaginal tablets causes the penetration of their active substance into various layers of mucous membranes, providing them with an antifungal effect. Depending on the type of active substance, the drug is either not absorbed into the blood, or a small amount of it is supplied to the interior of the body, which does not harm the health. Cases of overdose with these drugs were also not observed due to the peculiarities of their use.
Consider some of these drugs, covering all the groups of vaginal tablets.
Based on intraconazole
"Irunin" is an antifungal agent, produced in the form of vaginal tablets in the form of a ring. The drug is not absorbed into the blood, which allows its long-term use, for example, in the case of a chronic course of the disease. It is used in the amount of 1 tablet at night.
Side effects of the drug are very rare in the form of a slight irritation and do not require drug withdrawal. In the case of a pronounced allergic reaction from "Irunin" should be discarded by taking an antihistamine and thoroughly washing the vagina.
Contraindications to the use of this drug are mainly limited to hypersensitivity to the components and the 1 st trimester of pregnancy.
"Introconazole" is a vaginal suppository based on the same active substance, identical in properties with "Irunin".
Shelf life vaginal tablets itraconazole is under 2 years of stored them at a temperature below 25 for S.
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Based on clotrimazole
Despite the cheapness of the active substance and its inadequate activity against many fungi, in the case of Candidiasis, clotrimazole shows sufficient effectiveness. In part, this is due to a fairly large number of different drugs based on it.
"Kanison" - vaginal tablet oblong form of 100 mg with a 6-day course of treatment. The active substance is clotrimazole.
Candide - vaginal tablets of 100 or 500 mg each, rounded at one end, based on clotrimazole. Treatment with 100 mg tablets is carried out somewhere for a week. Tablets 500 mg provide for a single use. This dose is considered sufficient for the course of treatment of acute forms and for the prevention of the disease.
"Kandizol" - vaginal tablets of 100, 200 and 500 mg. The duration of the drug depends on the dosage. For tablets of 100 mg, the course of treatment is 6 days, 200 mg for 3 days, 500 mg for 1 day.
"Kandibene" - biconvex oblong vaginal tablets from candidiasis for 100 and 200 mg with a course of therapy, respectively, 6 and 3 days.
"Clotrimazole" - oblong tablets, rounded at one end, intended for intravaginal use. Dosage of 100 mg. Therapy is carried out according to 2 schemes: 1 tablet once a day before bedtime for 6 days or 2 tablets twice a day for a course of 3 days.
Clotrimazole, along with the side effects inherent in intraoconazole, can have other side effects, such as headache and discomfort when urinating. It is undesirable to use vaginal products on its basis and in persons under 12 years of age.
Shelf life vaginal preparations with clotrimazole is 36 months storage at room temperature (25 to about C).
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Based on miconazole
"Klion-D" - oval vaginal tablets of 100 mg with engraving, based on miconazole (anti fungus) and metronidazole (antibiotic), which have anti-inflammatory, antibacterial and antifungal effects. Therapeutic course is 10 days.
In addition to the usual contraindications to use, such as age 12 years, the first months of pregnancy and individual intolerance, the drug has other prohibitions to use, such as the presence of a history of leukopenia, kidney failure, some violations in the central nervous system. Disturbances of microcirculation and diabetes mellitus provides some caution in the application of "Klion-D" and consultation with a doctor.
The drug also has a large bunch of side effects : local reactions (irritation of mucous and itching, increased secretions with odor), digestive and caloric disturbances, changes in urine color, changes in blood composition, headaches, allergic reactions, etc.
Interaction with other drugs. The presence of metronidazole in the composition causes some limitations on the joint use of the "Klion-D" tablets with other medications. The drug should not be taken in parallel with sulfonamides and antibiotics, with alcohol and disulfiram. Dose correction is required when used simultaneously with lithium, cimetidine, phenobarbital and phenytoin.
The storage conditions of the drug implies the preservation of its properties for 5 years at a temperature of not more than 30 degrees.
"Ginezol" - vaginal suppository of 100 mg with miconazole, which have fewer contraindications than the previous preparation with the same active substance. The course of treatment is about a week. Shelf life of the drug at t up to 30 о С is 4 years.
It is better to give up suppositories to children under 12 years old, in the first months of pregnancy and hypersensitivity to the drug, and also to be careful with diabetes and microcirculation disorders.
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Based on nystatin
Vaginal tablets with nystatin are often supplemented with a broad-spectrum antibiotic. These are effective tablets from candidiasis of topical application with anti-inflammatory, antimicrobial, antifungal and destroying effect on the simplest microorganisms in the human body.
"Terzhinan" - a combined preparation in the form of oblong flat vaginal tablets of yellowish color. In its composition, the anti-inflammatory component (prednisolone), the antibiotic (neomycin), the antifungal agent (ternidazole) and, finally, the antifungal antibiotic (nystatin) perfectly coexist. Treatment of candidiasis with this drug is carried out for 10, sometimes 20 days, the preventive course is limited to 6 days when using the drug once a day at night. The drug can be continued during menstruation.
Despite the rich composition, the preparation has practically no contraindications to use, except for individual intolerance. And side effects are limited to a slight irritation of the mucosa. Allergic reactions to the drug are rare.
The drug retains its effectiveness during the expiration date, which is 3 years if stored at room temperature, not exceeding 25 degrees.
In vaginal tablets "Giterna" the role of an antifungal agent is replaced by metronidazole instead of teridazole, which provides antiprotozoal effect of the drug. Tablets of flat-cylindrical form of yellowish color. Apply them according to the same scheme as the previous product.
This drug also actually has no contraindications and side effects. An overdose of him was also not seen in clinical trials. The shelf life of the drug under the appropriate storage conditions is 24 months.
"Polizhinaks" is an effective preparation in the form of vaginal capsules with antifungal and antimicrobial action. The latter is due to the presence of neomycin and polymyxin in the formulation.
The course of treatment is usually limited to 12 days when the drug is used in an amount of 1 tablet per night, without interrupting the course of therapy during menstruation. To prevent disease, a 6-day course is sufficient.
Contraindications to the use of tablets "Polizhinaks" are: the first 3 months of pregnancy, breastfeeding, individual intolerance of the components of the drug. Side effects of the drug are manifested in the form of irritation of mucous and small local allergic reactions.
Keep the tablets from candida "Polizhinaks" at room temperature for 2 years from the date of release.
Nystatin is produced and actually in pure form in the form of suppositories with the same name. Suppositories "Nystatin" are available for both vaginal and rectal administration (with intestinal candidiasis).
As for interaction with other drugs, nystatin-based drugs should not be combined with drugs containing clotrimazole, since in this case the therapeutic effect of the latter is significantly reduced.
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Based on ketoconazole
Suppositories " Livarol " is used in the treatment of both acute and chronic candidiasis. It is also an excellent preventive tool. The active substance - ketoconazole - acts on the membrane of the fungal cells, which leads to its death.
In acute disease, the suppository is recommended to be applied once a day for not more than 3-5 days, with chronic candidiasis, the course of treatment can reach a ten-day period.
Contraindications to the use of the usual: a short period of pregnancy (up to 3 months) and intolerance of ketoconazole. Nevertheless, children under 12 years of age, breastfeeding and later pregnancy mean the use of suppositories only according to the doctor's indications.
Side effects of the drug are usually small: minor irritation and reddening of the mucous genitalia, as well as a slight itch. Allergic reactions are very rare.
Store this medication can be no more than 2 years from the date of issuance at a temperature below 25 on the S. End of the expiration date indicates that the drug continue to use inappropriate.
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Based on levorin
Levorin is an antifungal antibiotic, on the basis of which several forms of the drug are produced (this applies to many of the above-mentioned agents with other active substances). Vaginal tablets "Livarol" - only one form of the drug, intended for local treatment of candidiasis in women.
The drug therapy is usually carried out for 2 weeks with a daily two-fold application of 1 or 2 tablets. Sometimes you need to repeat the course 2-3 weeks later.
With vaginal application, the drug exhibits few side effects, usually it is a minor local reaction of the immune system. Contraindications to the use of suppositories "Levorin" are the first 3 months of pregnancy and hypersensitivity to levorin.
Unlike other drugs, "Levorin" requires special storage conditions : a cool place protected from the sun with an air temperature of no higher than 4 o C. This condition is relevant for all forms of the drug.
Local treatment of candidiasis in men and children (if there are no corresponding contraindications) is carried out by the same antifungal drugs, but already in the form of creams and solutions, as well as antiseptic agents.
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Tablets from candidiasis for oral use
As already mentioned, tablets with local effects on the fungus cure severe forms of candidiasis, especially with the spread of the gastrointestinal tract, it is simply impossible. Here we receive help from tablets from candidiasis of a wide spectrum of action, which are introduced into the body through the mouth. Usually, these tablets contain the same active substances as the above-mentioned vaginal suppositories.
An exception is fluconazole-based drugs, which, like other antifungal agents, destroy fungi at the cellular level, preventing them from growing and spreading, but less toxic to the body than other substances with a similar effect. Pharmacodynamics of drugs with fluconazole is similar to that of drugs with other antifungal active substances.
Pharmacokinetics. Preparations based on fluconazole are well absorbed by the body, as it quickly penetrates into any body fluids, which causes its rapid spread and good therapeutic effect. These drugs are well tolerated by the body and have virtually no contraindications.
Names of tablets from candidiasis based on fluconazole may differ, but they all have remarkable antifungal and bactericidal actions, without which it is simply impossible to get rid of neglected forms of candidiasis.
"Fluconazole" is an antifungal drug used in the treatment of candidiasis and other fungal infections. Produced in the form of tablets (capsules), gel, syrup and solution. Fluconazole in the form of suppositories is rare, and perhaps not an original product.
The method of administration and dosage of tablets from Candidiasis "Fluconazole" is determined by the doctor based on the age of the patient and the type of candidiasis, and provides for various treatment regimens. The therapeutic course usually lasts from a few days to 1 month. When prescribing other drugs concomitantly with fluconazole, the doctor should take into account the drug interactions of these agents.
In addition to individual intolerance to fluconazole, the drug also has other contraindications to use : children under 4 years of age and simultaneous use of fluconazole and preparations of Terfenadin or Astemizol. It is undesirable to use the drug during pregnancy and feeding. Caution in the use of the drug should be observed patients with hepatic and renal insufficiency, as well as with certain heart diseases.
Perhaps the emergence of side effects in the form of rashes, head and stomach pains, nausea, liver reactions, which does not always require withdrawal of the drug.
Other drugs with active substance fluconazole: "Fucis", "Diflucan", "Difluzolum", "Flukostat", "Mikomaks", "Mycosyst".
"Fucis" is one of the most loved drugs from candidiasis, both in doctors and patients. The reason is good efficacy of the remedy for candidiasis of a wide spectrum of action, as well as the fact that these are rather cheap tablets from candidiasis, second only to Nystatin and Klotrimazol.
In pharmacies, you can find tablets from candidiasis "Fucis" in different dosages, which facilitates its use depending on the form and severity of the disease. The drug is well absorbed by the body and has a pronounced antifungal effect. Nevertheless, he has certain contraindications to the use. It is not prescribed for pregnant and lactating mothers, children under 7 years of age and patients with intolerance to the components of the drug.
"Fucis" can provoke and the development of some side effects from the gastrointestinal tract and cardiovascular systems, allergic reactions, as well as violations in the work of the central nervous system, which are amplified by an overdose of the drug.
A fairly popular drug on the basis of fluconazole is "Difluzol". This drug is a new generation, which is famous for its ability to suppress the synthesis of building elements of fungal cells. As well as the previous preparation, it possesses good digestibility and long-term action. The dosage of "Difluzole" depends on the type and location of the fungal infection, and can range from 50 to 400 mg per day, and the course of treatment from 1 day with vaginal candidiasis to 2 weeks in advanced cases of mucosal candidiasis.
The drug is also used to treat candidiasis in newborns and children. Then the dosage and the way of use are prescribed by the doctor based on the age and weight of the small patient.
By contraindications for the use of the drug can be attributed pregnancy and lactation, liver pathological processes, the arrhythmia. Hypersensitivity reactions to the drug are possible. Has a pretty decent list of side effects.
The intake of "Fucis" and "Difluzol" requires caution and consideration of their interaction with other drugs. Therefore, the attending physician should be informed about the drugs that you take to treat other health problems.
A great popularity in the treatment of candidiasis received tablets from candidiasis " Pimafucin " with the active substance natamycin, which is an antifungal antibiotic. This drug is available in the form of tablets and suppositories, the simultaneous use of which is indicated in severe forms of candidiasis. There is a form of release and in the form of a cream.
The drug is intended for the treatment of candidiasis of the skin and mucous membranes, including candidiasis of the intestine. In this case, the method of administration and dosage of tablets from candidiasis remains unchanged: 4 tablets per day (pediatric norm - 2 tablets per day), one at a time. Only the course of treatment differs: from 7 days with intestinal candidiasis to 3 weeks in severe cases of vaginal fungal infection.
The main and only contraindication to the use of "Pimafucin" are hypersensitivity reactions to the components of the drug, so doctors consider it quite acceptable the use of these tablets from candidiasis during pregnancy. Natamycin itself is not able to harm the fetus, its mother or provoke abortion.
Do not dazzle the instruction to the drug and side effects from its administration. Sometimes there are small problems with the gastrointestinal tract in the form of nausea and diarrhea, but they completely disappear after a couple of days. There were no cases of drug overdose.
"Pimafucin" does not react with other drugs, which further expands the use of this effective and fairly safe drug. A fairly long shelf life (4 years) avoids the use of an overdue medication.
Another drug with virtually no contraindications, which is suitable for the treatment of candidiasis in pregnant women and children over 3 years of age, is called Miramistin. It is a broad spectrum antiseptic with a noticeable antifungal and antiviral effect. Produced in the form of a solution (spray) and ointment.
For babies with candidiasis of the oral mucosa, tablets from candida "Nystatin" and "Candide" are more suitable. But since the use of drugs in tablets in children is difficult, they are prescribed the above-mentioned funds in the form of drops and ointments, which are applied to a gauze swab designed for wiping the baby's mouth.
Probably, many know about the existence of an effective antifungal shampoo for dandruff "Nizoral". But not everyone knows that doctors with the same name are successfully used in the treatment of candidiasis.
"Nizoral" is an antifungal agent based on ketoconazole. Its usual dosage is -1 tablet (200 mg) per day, but sometimes doctors resort to double the dose. The dose for children weighing up to 30 kg is 100 mg.
Among the contraindications to the use it is worth highlighting the individual intolerance of the components of the drug, as well as liver and kidney disease. Nezoral is not intended for antifungal therapy for pregnant and elderly people (over 50).
Side effects : migraine, short nausea, sometimes accompanied by vomiting, violation of skin sensitivity, shifts in the menstrual cycle in women, etc.
The antifungal drug " Thermicone " is valued for its ability to destroy the cellular structure of fungi at an early stage of biosynthesis. The drug is intended for the treatment of adults and children over 3 years of age with a body weight of more than 20 kg. It is not recommended to take "Tirmikon" during pregnancy and breastfeeding, as well as in case of individual intolerance of individual components of the drug.
Method and dosage of tablets from candidiasis. Adults and children with a body weight of more than 40 kg are prescribed 1 tablet once a day after meals. If the weight of the child is within 20-40 kg, the dosage is reduced by half.
Patients with hepatic and renal insufficiency, alcoholism symptoms, metabolic disorders, tumors and certain diseases of the extremities and hemopoiesis require adjustment of the dose of the drug.
Side effects. The drug can cause certain abnormalities in the work of the digestive tract and in the blood, as well as allergic manifestations in the form of rashes. An overdose of the drug causes an increase in side effects associated with the gastrointestinal tract, as well as dizziness and weakness.
The shelf life of "Thermicon" at room temperature is 3 years. The shelf - life of drugs from candidiasis is an indicator of not only the effectiveness, but also comparative safety for human health, therefore, it should not be neglected.
In addition to the above, there are other drugs from thrush, the expediency of appointment is determined by the attending physician. From the patient it is required only to strictly follow the doctor's recommendations, and therefore use tablets from candidiasis for the intended purpose, adhere to the necessary dosage, multiplicity and duration of treatment, not stopping taking drugs only because of the disappearance of the symptoms of the disease, which is fraught with relapse and the transition of the disease to chronic form.