The preparation is irrigated with the skin surface in the area of infection, previously cleaned from keratinized tissues and dried, and also - surrounding healthy skin (the focus of the lesion should be well moistened).
The duration of therapy and the frequency of use of the spray are determined individually, depending on the causative agent of the infection and the general health of the patient.
The condition of the affected area of the skin noticeably improves a few days after the start of treatment. In the absence of signs of recovery, a week after starting the use of the spray should be reported to the attending physician (in the treatment of onychomycosis, the improvement usually becomes noticeable after several months).
Thermicon, Lamicon, Lamisil
Antimycotics for external use. The active component of the sprays is terbinafine, a representative of allylamines, which has the ability to disrupt the biosynthesis process of the main component of the membrane of the fungal cell - ergosterol. Fungicidal action of the preparations is to inactivate the enzyme squalene epoxidase, the catalyst of the third, penultimate stage of ergosterol biosynthesis. Its deficiency with simultaneous concentration of squalene in the membrane kills fungal cells.
Squalene epoxidase of human skin cells is not susceptible to terbinafine, which explains the selective effect only on fungal cells.
These sprays have a fungicidal effect on the causative agents of the epidermophytosis, trichophytosis, microsporia, pityriasis, candidiasis, and also on dermatophytes, aspergillus, cladosporiums, scopularyopsis.
Different types of yeast fungi have either a fungicidal or fungistatic effect.
Absorption of terbinafine with topical application up to 5%. The manifestations of the systemic effect of the drug are insignificant.
The use of sprays from fungus during pregnancy and lactation is not thoroughly studied, therefore they can be prescribed only when necessary. Studies have not identified adverse effects of terbinafine on intrauterine fetal development.
Terbinafine is found in breast milk, so it is best to abstain from breastfeeding.
Contraindications to use - allergy to the ingredients of the drug; the period of breastfeeding; age up to 3 years.
Use with caution in cases of: impaired liver function and / or kidney function; alcoholism; neoplasms; disturbance of metabolic processes, hematopoiesis processes, patency of the vessels of the extremities.
Recommended duration of application: with dermatomycosis and epidermophytosis, the lesion is irrigated once a day for one week; with pityriasis - twice a day for one week.
Keep two years, observing the temperature regime up to 25 ° C, in a dry place. Keep away from children.
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Antimycotic for external use. The active ingredient of the spray, bifonazole, has a fungicidal action against trichophytes, epidermophytes, pathogens of microsporia and candidiasis. It has a fungistatic effect on yeast fungi of the genus Malassezia, asspergilla, scopulariopsis, corynebacterium, gram-positive cocci (except enterococci).
Bifonazole inactivates one of the catalysts for ergosterol biosynthesis (cytochrome P-450), which causes ergosterol deficiency and accumulation of its precursors in the fungal cell membrane. This process destroys the structure of the cell membrane and destroys the cell.
The spray completely penetrates the infected layers of the skin, and is not absorbed into the blood. Six hours after irrigation of the lesion, the level of accumulation of bifonazole in the skin exceeds the minimum effective concentration, which is detrimental to the causative agents of dermatomycosis. It is found in the skin for up to 2 days. The duration of the half-life from 19 to 32 hours depends on the permeability of the skin.
Bifosin spray during pregnancy: in the first three months - only if necessary, in the remaining six months - according to the indications.
Bifonazole penetrates into breast milk, therefore it is better to abstain from breastfeeding during breastfeeding.
Contraindications to use - allergy to any ingredient Bifosin, the period of breastfeeding.
Method and duration of application: Antifungal spray Bifosin treat the affected surface once a day in the evening before bedtime.
The therapeutic effect comes with continuous use of the spray for:
- fungal lesions of feet and interdigital intervals of feet - from three to four weeks;
- fungal lesions of the scalp - four weeks;
- fungal lesions of smooth skin - from two to three weeks;
- multi-colored lichen, epidermophytia of large folds - two weeks;
- surface skin lesions of Candida fungi - from two to four weeks.
Keep two years, observing the temperature regime up to 25 ° C, in a dark place. Keep away from children.