Ebermine

Ebermin is one of the newest drugs that inhibits the proliferation of microbes and stimulates the healing of tissues damaged by burns, wounds or skin erosions. The drug's action is so soft and gentle that it prevents the appearance of excessive scar tissue growth and contractures at the site of the wound surface.

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Indications Ebermine

The product is prescribed for the treatment of burn injuries to the skin, both superficial and deep penetration, and it has been proven that the use of the drug significantly reduces the overall duration of tissue regeneration.

The ointment is used when there is a need for granulation of damaged tissues, as well as to accelerate the engraftment of skin grafts.

The main indications for the use of Ebermin are:

• mug;
• thermal burn injuries;
• trophic ulcers;
• bedsores;
• damage to the integrity of the skin due to frostbite;
• ulcers resulting from the use of cytostatics;
• radiation dermatitis;
• surgical and purulent wound surfaces;
• use of radiotherapy.

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Release form

The drug is produced in the form of an external ointment, which is a light, homogeneous substance with a delicate creamy consistency and a subtle, distinctive odor.

The medicinal substance is available in 30 or 200 g vials. It contains 0.01 mg of human epidermal growth factor and 1 g of silver 2-sulfanylamidopyrimidine, supplemented with a hydrophilic filler.

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Pharmacodynamics

The preparation has a peptide component that stimulates the migration and proliferation properties of fibroblast, keratinoid cells, as well as endothelium, which take an active part in the regeneration of the wound surface. This promotes normal epithelial proliferation, the scarring process with restoration of elastic tissue properties.

The growth factor is produced by DNA recombination; in terms of dynamics, it has extreme similarities with the endogenous factor, which is synthesized by the body.

Sulfanylamidopyrimidine supports the regenerative process with its extensive antibacterial action: it is effective against various types of microbes, as well as candidal fungi and dermatophytes.

The auxiliary substances present in the ointment help to moisturize the wound surface, reduce pain and maintain the required concentration of the drug in the treated area.

Ebermin promotes the process of natural collagenosis, preventing the formation of keloid cicatricial changes and tissue hypertrophy.

Pharmacokinetics

The ointment has an exclusively external local effect on the affected tissues: absorption of active substances into the circulatory system does not occur.

Dosing and administration

The drug can be used at almost any stage of burn and ulcerative lesions.

After mandatory antiseptic treatment of the wound surface, the wound is dried, then a medicinal substance is applied in a thin layer (approximately 1.5 mm). The treated area is covered with a gauze napkin or sterile bandage. The ointment is usually used once a day, but more frequent or rare use of the drug is also allowed.

If, when removing the bandage, it is found to be stuck to the wound surface, it is recommended to moisten the bandage with saline, furacilin solution, or another antiseptic.

If a bandage is not applied and wound healing occurs using an open method, the use of the ointment should be increased to 3-4 times a day.

The procedure of changing the dressing and applying the ointment should be carried out extremely carefully so as not to injure the forming granulation and epithelial tissue.

The duration of treatment is determined by many factors and is prescribed individually.

Use Ebermine during pregnancy

There is currently no reliable data that would allow us to make a clear judgment about the effect of Ebermin on the growth and development of the embryo, as well as on pregnancy itself. As a result, many doctors do not recommend using this drug during pregnancy and breastfeeding.

On the other hand, it is known that the drug is not absorbed into the general bloodstream, which allows us to assume some safety of treatment of pregnant women with this drug.

Based on the above, the question of the advisability and necessity of using the drug Ebermin by pregnant women should be decided by a specialist, based on the determination of the existing risk and benefit for the expectant mother.

Contraindications

The main contraindications to the use of the drug:

• the possibility of allergic reactions to any component of the ointment;
• pregnancy, breastfeeding, newborns and premature babies;
• the presence of neoplasms at the site of application of the drug;
• use of ointment to stimulate the healing of surgical wounds obtained after complete or partial removal of neoplasms;
• severe liver and urinary tract dysfunction.

Side effects Ebermine

Side effects are rare for this medicine. However, if the body is hypersensitive, an allergic reaction to sulfonamides or medicines containing silver may develop. This is expressed in hyperthermia, facial flushing, skin rash, discomfort on the skin, soreness, and tightness of the skin.

If side effects occur, it is recommended to stop using the ointment.

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Overdose

Signs of drug overdose may include symptoms of toxic effects of sulfonamides:

• dyspeptic disorders;
• joint pain;
• the appearance of convulsions;
• liver and kidney dysfunction;
• drowsiness.

Overdose therapy is symptomatic, and it is recommended to take large amounts of fluid. In severe cases, blood transfusion and hemodialysis are used.

Interactions with other drugs

There are no data on adverse interactions of the drug with other medications. Incompatibility or negative effects on other external drugs were not noted.

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Storage conditions

The drug is stored in a dark place at room temperature. Keep out of reach of children.

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Shelf life

Shelf life is up to two years if stored properly. After the expiration date, it is recommended to throw the drug away.