The drug "Ovestin" with menopause in women: cream, gel, candles

Ovestin is a hormonal drug. Consider the indications for its use, dosage, possible side effects and other features of the instruction.

Menopause is a period of hormonal changes in the female body, which can worsen the quality of life. This period is dangerous by various pathological processes due to a decrease in the production of estrogens. That is why they use substitution therapy, whose action is aimed at eliminating the deficiency of female sex hormones.

Ovestin with menopause is needed to restore the vaginal epithelium and normalize the vaginal microflora. The active substance of the drug - estriol, refers to natural female sex hormones. This component affects only the organs of the genitourinary system: the vagina, the cervix, the vulva and the urethra.

The peculiarity of the drug is that it begins to function in the first days after application, significantly improving the condition of the woman. It restores normal microflora, eliminates dryness and itching, fights with urinary incontinence.

Indications of the ovestina with menopause

The replacement hormone therapy during the menopause allows you to restore the level of sex hormones. Indications for use Ovestin with climax are based on the action of its active components. The medication is prescribed for:

• Age changes in the mucous membrane of the vagina atrophic nature, caused by a deficiency of estrogens.
• Increases in urination and pain.
• Urinary incontinence.
• Dryness, itching and discomfort in the vagina.
• Pain during intercourse.
• Treatment and prevention of inflammatory lesions of the urogenital area.
• Infertility (associated with cervical factor).
• Prevention of complications of surgical interventions with overvaginal access.

The drug is prescribed for diagnosis, with unclear cytological results of a vaginal smear.

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Release form

Ovestin has several forms of release:

• Tablets - capsules of 1 and 2 mg with active ingredient estriol. Additional components are: amylopectin, lactose monohydrate, potato starch, magnesium stearate and others. In one package 30 tablets
• Vaginal cream - is available in tubes of 15 g with an active ingredient estriol. Excipients: cetyl palmitate, lactic acid, octyldodecanol, chlorhexidine hydrochloride, sodium hydroxide and others.
• Vaginal suppository - each suppository contains 0.5 mg of estriol and Witepsol S 58. One package contains 15 suppositories.

Different forms of ovestin allow you to choose it individually for each patient.

Pharmacodynamics

Selective action of the drug is directed to the vagina, cervix and vulva. Pharmacodynamics causes an increase in the proliferation of the vaginal epithelium, stimulates its blood supply, eliminates atrophic changes caused by premenopause and menopause. Active components normalize the acid balance and microflora of the vagina, increase resistance to infectious and inflammatory diseases.

The hormonal agent has a minor effect on the endometrium. Lipidemic action is associated with an increase in the concentration of beta-lipoproteins in the blood, an increase in sensitivity to insulin. Improves the utilization of glucose, stimulates the production of globulins (bind female sex hormones). The drug stimulates parasympatopomimetic reactions, the synthesis of DNA and proteins.

Pharmacokinetics

Different forms of release Ovestin have the same effect on the effectiveness of the female body. Pharmacodynamics of tablets indicates a rapid and almost complete absorption after application. The maximum concentration of estriol in the blood plasma is achieved after 1-2 hours for intravaginal use.

About 90% of the active substance binds to albumin. Unlike other estrogens, estriol practically does not interact with globulin, which binds the sex hormones. The drug is displayed in unchanged spectacles. About 2% goes through the intestines. Excretion of metabolites begins several hours after application and lasts about 18-20 hours.

Dosing and administration

From the pathological condition and medical prescriptions, the mode of application and dose of ovestin depends. With climax, 4-8 mg of medication are shown regardless of the form of release. When the condition improves, the dosage is lowered.

• Atrophic changes in the mucous membrane of the vagina - 2-4 tablets once a day for a month. In the future, a maintenance dose of 1-2 capsules is indicated.
• Urinary incontinence - 1-2 suppository in the morning and before bedtime. If the cream is used, then it is injected with the help of the applicator 2 times a day. After improvement, the drug is used 2 times a week.
• Preparation for diagnosis with unclear cytological results of vaginal smears - 1 suppository every other day for 7 days. Therapy should last until the next diagnostic procedure. The cream is used according to the same scheme.
• Infertility associated with cervical factor - 1-2 mg per day from 6 to 15 day cycle. If necessary, the dosage can be increased to 8 mg per day.

If the drug is prescribed during the preparation for surgery with perevaginal access in menopausal women, then apply 1 suppository once a day. The introduction of suppositories must begin 14 days before the planned operation. If tablets are used, then 4-8 mg 14 days before surgery and 1-2 mg for two weeks after surgery. The cream is used in the same way.

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Contraindications

Ovestin is contraindicated in such cases:

• Intolerance of the components of the drug.
• Pregnancy.
• Vaginal bleeding of unknown etiology.
• Breast cancer in history or with a suspicion of it.
• Porphyria.
• Lesions of the liver in acute form, changes in liver samples.
• Venous or arterial thromboembolism in the anamnesis.
• Estrogen-dependent malignant tumors.
• Endometrial cancer or suspected of it.

With special care, the drug is prescribed for leiomyoma or endometriosis, arterial hypertension, thromboembolic disorders, benign liver tumors, cholelithiasis, diabetes mellitus, jaundice, liver failure, migraine, systemic lupus erythematosus, pancreatitis, epilepsy, endometrial hyperplasia in history and asthma. All of the above conditions require medical supervision when using ovestina.

Side effects of the ovestina with menopause

Failure to comply with medical recommendations on the use of the drug can cause different severity of side effects. Ovestin with menopause usually provokes irritation and itching in the vagina, pain and discomfort in the mammary glands, attacks of nausea. In rare cases, headaches and high blood pressure may occur.

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Overdose

The use of increased doses of ovine causes a number of unfavorable symptoms. Overdose is accompanied by attacks of nausea and vomiting, and vaginal bleeding is also possible. Since there is no specific antidote, symptomatic therapy aimed at improving the condition of a woman is indicated.

Interactions with other drugs

Climax is accompanied by hormonal changes, which can negatively affect the entire body. To improve the condition, complex therapy is used, aimed at eliminating the deficiency of female sex hormones and facilitating overall well-being. The interaction of Ovestin with other drugs should be controlled by the attending physician.

To date, no cases of adverse interactions have been documented, but given the pharmacological properties of estriol, care should be taken when using it with anticonvulsants, antibiotics, antiretroviral drugs and preparations based on St. John's Wort. In addition, estriol can increase the effectiveness of corticosteroids.

When used with opioid analgesics, anxiolytics and other drugs for general anesthesia, a decrease in their effect is observed. Medicines for the thyroid gland and folic acid increase the activity of estriol.

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Shelf life

Ovestin with menopause, as well as a number of similar drugs, is used to improve women's well-being. The drug has several forms of release. The shelf life of each of them is 36 months from the date of manufacture. At its expiration, the drug must be disposed of. The use of an expired medication is very dangerous, since it can provoke uncontrolled adverse reactions.