Diseases of children (pediatrics)

Thrombocytopathy

Thrombocytopathy - disorders of hemostasis, due to the qualitative inferiority of blood platelets with a normal number of them. Distinguish between hereditary and acquired.

Hapten immune thrombocytopenia

Symptoms of hapthenic immune thrombocytopenia develop acute. The formation of petechiae is spontaneous in nature. Purple is manifested by petechial-spotted hemorrhage into the skin and underlying cellulose, hemorrhages from the mucous membranes, and nosebleeds. There may be gastrointestinal and uterine bleeding in girls at puberty.

Wiskott-Aldrich syndrome in children

Wiskott-Aldrich syndrome is manifested by eczema, recurrent infections and thrombocytopenia. Symptoms of Wiskott-Aldrich syndrome appear in the neonatal period or in the first months of life. Most often, children die at an early age. In the neonatal period, bleeding is often represented by melena, and later purpura joins.

Thrombocytopenic purpura in children

Idiopathic (autoimmune) thrombocytopenic purpura is a disease characterized by an isolated decrease in the number of platelets (less than 100,000 / mm3) with a normal or increased amount of megakaryocytes in the bone marrow and the presence of antiplatelet antibodies on the surface of platelets and serum that cause increased destruction of platelets.

Diseases of platelets

With a decrease in the number of platelets or a violation of their function, bleeding may occur. The most typical bleeding from damaged skin and mucous membranes: petechiae, purpura, ecchymosis, nasal, uterine, gastrointestinal bleeding, hematuria. Intracranial hemorrhages are rare.

Thrombophilia: causes, symptoms, diagnosis, treatment

Thrombophilia is a chronic condition of the body, during which for a long period (months, years, throughout life) there is a tendency either to spontaneous thrombus formation or to uncontrolled spread of thrombus beyond the damage.

Von Willebrand's disease in children

Von Willebrand disease - a disease with an autosomal dominant type of inheritance - arises from a quantitative deficit or a qualitative defect in von Willebrand factor.

Hemophilia

Hemophilia is a group of hereditary diseases caused by a genetically determined defect in the synthesis of antihemophilic plasma factors.

Leukocyte adhesion deficiency: causes, symptoms, diagnosis, treatment

Deficiency of adhesion of leukocytes (Leukocyte Adhesion Deficiency - LAD). LAD type 1 - inheritance is autosomal recessive, the disease occurs in persons of both sexes. At the heart of the disease is a mutation of the gene that codes for the beta2 subunit of the neutrophil integrin (the central link of cellular complement-dependent interactions).

Kostmann's syndrome: causes, symptoms, diagnosis, treatment

Kostmann's syndrome (children's genetically determined agranulocytosis) is the most severe form of hereditary neutropenia. The type of inheritance is autosomal recessive, there may be sporadic cases and a dominant type of inheritance.

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