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Diseases of children (pediatrics)

Cherdz-Strauss Syndrome

Granulomatous inflammatory angiitis - Cherdz-Strauss syndrome refers to the group of systemic vasculitis with small-caliber vessels (capillaries, venules, arterioles) associated with the detection of antineutrophil cytoplasmic autoantibodies (ANCA). In children, this form of systemic vasculitis is rare.

How is Takayasu's disease treated?

In the acute phase, average doses of prednisolone (1 mg / kg / day with a decrease in dose 1-2 months to the maintenance dose) and methotrexate (not less than 10 mg / m21 once a week) are prescribed. The maximum dose of prednisolone is given before the disappearance of clinical and laboratory signs of the activity of the process, after which it is slowly reduced to maintenance (10-15 mg / day).

Diagnosis of Takayasu's disease

The diagnosis of nonspecific aortoarteritis is established on the basis of typical clinical signs and data of instrumental studies.

Symptoms of Takayasu's disease

Non-specific aortoarteriitis is characterized by general inflammatory manifestations and a combination of various syndromes: insufficiency of peripheral blood flow, cardiovascular, cerebrovascular, abdominal, pulmonary, arterial hypertension. A classic symptom of the disease is the syndrome of asymmetry or lack of pulse.

What causes Takayasu's disease?

There are no reasons for Takayasu's illness. Possible causes include the role of infection (in particular, tuberculosis), viruses, drug and serum intolerance. There is evidence of a genetic predisposition to non-specific aortoarteritis, as illustrated by the development of the disease in identical twins and the association with HLA Bw52, Dwl2, DR2 and DQw (in the Japanese population).

Nonspecific aortoarteritis (Takayasu's disease)

Nonspecific aortoarteritis (aortic arch syndrome, Takayasu's disease, lack of pulse) - destructive-productive segmental aortitis and subaortic panarritis of the arteries rich in elastic fibers with possible damage to their coronary and pulmonary branches.

Mucous-cutaneous lymphonodular syndrome (Kawasaki syndrome): causes, symptoms, diagnosis, treatment

Mucous-cutaneous lymphonodular syndrome (acute children's feverish cutaneous mucocutaneous glandular syndrome, Kawasaki's disease, Kawasaki syndrome) is an acute systemic disease characterized by a morphologically predominant lesion of the middle and small arteries with the development of destructive-proliferative vasculitis identical to nodular polyarteritis, and clinically - fever, changes in mucous membranes, skin, lymph nodes, possible damage to coronary and other visceral arteries.

How is polyarteritis nodosa treated?

Medicamentous treatment of nodular polyarteritis. Medical treatment is carried out taking into account the phase of the disease, the clinical form, the nature of the main clinical syndromes, severity. It includes pathogenetic and symptomatic therapy.

Diagnosis of nodular polyarteritis

Recognition of nodular polyarteritis is often difficult, which is associated with nonspecific initial symptoms, polymorphism of clinical manifestations, the absence of specific laboratory markers.

Symptoms of nodular polyarteritis

For an acute period of nodular polyarteritis characterized by an increase in temperature, pain in the joints, muscles and various combinations of typical clinical syndromes - cutaneous, trombangiotic, neurological, cardiac, abdominal, renal.

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