What causes Takayasu's disease?
Last reviewed: 23.04.2024
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Causes of Takayasu disease
There are no reasons for Takayasu's illness. Possible causes include the role of infection (in particular, tuberculosis), viruses, drug and serum intolerance. There is evidence of a genetic predisposition to non-specific aortoarteritis, as illustrated by the development of the disease in identical twins and the association with HLA Bw52, Dwl2, DR2 and DQw (in the Japanese population).
[Pathogenesis of Takayasu's disease
In the pathogenesis of nonspecific aortoarteritis, autoimmune mechanisms are more important. In the pathological process involved the vasa vasorum , media and adventitia of the aorta and large blood vessels in their mouth or proximal. At a microscopic examination, mucoid swelling, fibrinoid necrosis, infiltrative-proliferative cellular reaction and sclerosis of the walls of the affected parts of the vascular system are revealed with a characteristic picture of segmental destructive, destructive-proliferative and fibroplastic panaortitis and panarrititis. The destruction of the elastic framework can lead to the formation of aneurysms, and thrombovasculitis and deformation of the lumen of the vessels - to arterial occlusion, which is clinically manifested by ischemic disorders and asymmetry or lack of pulse.