Diseases of children (pediatrics)

Juvenile dermatomyositis

Juvenile dermatomyositis (juvenile idiopathic dermatomyositis, juvenile dermatopoly myositis) is a serious progressive systemic disease with a predominant lesion of the striated muscles, skin and vessels of the microcirculatory bed

How is systemic lupus erythematosus treated?

Systemic lupus erythematosus is a chronic disease in which complete and definitive cure can not be achieved. The goals of the treatment are to suppress the activity of the pathological process, to preserve and restore the functional capabilities of the affected organs and systems, to induct and maintain clinical and laboratory remission, to prevent relapses in order to achieve a significant life expectancy of patients and to ensure a sufficiently high quality of it.

Diagnosis of systemic lupus erythematosus

The diagnosis of systemic lupus erythematosus is based on the patient's clinical, instrumental, laboratory and morphological features, which requires a comprehensive examination.

Symptoms of systemic lupus erythematosus

Symptoms of systemic lupus erythematosus are characterized by pronounced polymorphism, but almost monoclonal variants of the debut of the disease are observed in almost 20% of children. The course of systemic lupus erythematosus usually wavy, with alternating periods of exacerbations and remissions. In general, systemic lupus erythematosus in children is characterized by a more acute onset and course of the disease, earlier and rapid generalization and less favorable outcome than in adults.

Pathogenesis of systemic lupus erythematosus

A distinctive feature of systemic lupus erythematosus is the violation of immune regulation, accompanied by a loss of immunological tolerance to its own antigens and the development of an autoimmune response with the production of a wide range of antibodies, primarily chromatin (nucleosome) and its individual components, native DNA and histones.

Causes of systemic lupus erythematosus

The causes of systemic lupus erythematosus are still unclear, which causes difficulties in diagnosis and treatment. It is believed that various endo- and exogenous factors influence the development of the disease.

Classification of systemic lupus erythematosus

The nature of the course and the degree of activity of systemic lupus erythematosus are established in accordance with the classification of VA. Nasonova (1972-1986). The nature of the course is determined taking into account the severity of the onset, the time of onset of generalization of the process, the features of the clinical picture and the rate of progression of the disease.

Systemic lupus erythematosus

Systemic lupus erythematosus is a systemic autoimmune disease of unknown etiology, which is based on a genetically determined impairment of immune regulation that determines the formation of organonesspecific antibodies to cell nucleogen antigens with the development of immune inflammation in the tissues of many organs.

Behcet's disease in children

Behcet's disease - systemic vasculitis of small vessels with necrosis of the vascular wall and perivascular lymphomonocyte infiltration; is characterized by a triad in the form of recurrent aortic stomatitis; genital ulceration and uveitis. It occurs at any age, but in children Behcet's disease is a rare pathology. The genetic predisposition, communication with HLA-B5, B-51h, DRW52 was revealed.

Microscopic polyarteritis

Microscopic polyarteritis - necrotizing vasculitis with small vessel damage associated with antineutrophil cytoplasmic autoantibodies (ANCA); It is common in many organs and systems, but the most pronounced changes are observed in the lungs, kidneys and skin. Isolated into a separate nosological form of systemic vasculitis in recent years and included in the 1992 classification.

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