Diprosalik

Diprosalik is a combination medicine containing two active ingredients: betamethasone and salicylic acid. It is often used to treat various skin conditions such as eczema, dermatitis, psoriasis and other inflammatory skin conditions accompanied by itching, redness and irritation.

Betamethasone is a glucocorticosteroid that reduces inflammation, itching and swelling in the skin, and reduces immune system activity. Salicylic acid has keratolytic properties to help reduce skin exfoliation and facilitate penetration of betamethasone.

Diprosalik is available in various forms such as ointment, cream, gel or solution for external application. It is usually applied to the affected areas of the skin twice a day or as recommended by your doctor.

It is important to use Diprosalik only as prescribed by a doctor and follow their instructions, as improper use or use on inappropriate areas of the skin can lead to side effects or worsen symptoms of the condition.

Indications Diprosalica

1. Allergic and inflammatory skin conditions: Diprosalik is often used to treat atopic dermatitis, eczema, contact , allergic, seborrheic dermatitis and other allergic or inflammatory skin conditions.
2. Psoriasis: Especially when psoriasis is accompanied by intense itching or profuse flaking.
3. Hyperkeratosis: Used to soften and reduce acne, horny skin and hyperkeratosis of the feet.
4. In the presence of inflammation and itching on the skin.
5. Nevus, inflammation of small blood vessels in the skin.
6. Localized nevus.
7. Ichthyosis (an inherited skin condition characterized by dry and flaky skin).

Release form

1. Cream: This is one of the most common forms where the medicinal substance is in a cream base. The cream is applied directly to the skin and is well absorbed, providing relief from various dermatologic problems.
2. Ointment: This is a thicker form of the product that is designed to last longer and moisturize the skin. Ointment is usually recommended for drier or thicker areas of skin.
3. Gel: The gel has a light texture and absorbs quickly into the skin, usually leaving a cooling sensation. This form of release may be preferred by those who prefer a light texture and quick action.
4. Spray: The spray version of Diprosalik allows you to evenly distribute the drug over the skin, which is especially convenient for treating large areas or hard-to-reach places.
5. Solution for external use: This option can be used to rinse the skin or to add to a bath to relieve symptoms of dermatologic problems over large areas of skin.

Pharmacodynamics

1. Betamethasone (glucocorticosteroid):

   • Betamethasone is a potent glucocorticosteroid that has anti-inflammatory, anti-allergic and anti-edema effects.
   • This component inhibits the activity of phospholipase A2, which leads to a decrease in the synthesis of prostaglandins and leukotrienes, key mediators of inflammation.
   • Betamethasone also inhibits the migration of leukocytes to the site of inflammation, which helps to reduce the inflammatory response.

2. Salicylic acid (keratolytic):

   • Salicylic acid is a keratolytic agent that helps dissolve and exfoliate keratinized skin cells.
   • It helps to reduce the thickness of the stratum corneum of the skin, which is especially important in the treatment of diseases associated with hyperkeratosis, such as psoriasis and keratoderma.

Pharmacokinetics

1. Absorption: After external application of Diprosalik through the skin, the active ingredients may be absorbed into the bloodstream. Absorption will depend on skin condition, area of application, presence of skin lesions and other factors.
2. Distribution: After absorption, betamethasone and salicylic acid are distributed in the body. They can penetrate into various tissues and exert their action at the site of inflammation in the skin.
3. Metabolism: Both active ingredients may undergo metabolic processes, mainly in the liver. However, metabolism during external use is usually insignificant compared to systemic use.
4. Excretion: Metabolites of betamethasone and salicylic acid are usually excreted with urine and feces.
5. Half-excretion: Since Diprosalik is applied externally, its half-excretion from the body is mainly determined by the rate of metabolism and excretion of active components.
6. Pharmacokinetics in special cases: The pharmacokinetics of Diprosalik may be altered in patients with damaged skin, inflammation or other skin conditions that may increase absorption of the drug.

Dosing and administration

1. Method of Application:

   • Before using Diprosalik, the skin area where the drug will be applied should be cleaned and dried.
   • Cream or ointment is applied in a thin layer to the affected areas of the skin and gently rubbed until completely absorbed.
   • The medication is usually applied 1-2 times a day depending on your doctor's recommendations.

2. Dosage:

   • Diprosalik dosage depends on the severity of the disease, the area of the lesion, age and other factors.
   • It is usually recommended to apply a thin layer of cream or ointment to the affected areas of the skin 1-2 times a day.
   • For children, the dosage may be reduced and should be determined by a physician.

3. Duration of treatment:

   • The duration of Diprosalik treatment depends on the nature of the disease and the response to therapy.
   • It is generally recommended to use the drug for a limited time, usually no more than 2-4 weeks without consulting a doctor.

4. Cautions:

   • Avoid contact with eyes, open wounds or mucous membranes.
   • Do not use more of the drug than your doctor recommends.
   • Do not use Diprosalik on large areas of skin or for long periods of time without consulting your doctor, as it may cause side effects.

Use Diprosalica during pregnancy

The use of Diprosalik during pregnancy should be cautious and under medical supervision. In general, it is preferable to avoid the use of glucocorticosteroids such as betamethasone during the first trimester of pregnancy, when the fetal organs are forming, because of the risk of congenital anomalies and other complications.

However, in some cases, when the potential benefits outweigh the risks, your doctor may prescribe Diprosalik during pregnancy. This may be, for example, in the case of a severe exacerbation of a skin disease that cannot be controlled by other treatments and when the risk to the mother and fetus from the uncontrolled disease exceeds the potential risks of the drug.

Contraindications

1. Tolerance to hormonal drugs or any other components of the drug.
2. Herpetic skin infections (herpes, shingles).
3. Viral skin infections (including chicken pox).
4. Pustular skin infections (pyoderma).
5. Skin tuberculosis.
6. Various forms of rosacea (lupus erythematosus).
7. Open wounds or ulcers on the skin.
8. Acne (if acne is present, it is not recommended to use hormonal medications without consulting a dermatologist).
9. Syphilis of the skin.
10. Subdermal cutaneous prurigo.
11. After vaccination (the drug may slow down skin regeneration).
12. Period of pregnancy and breastfeeding (the drug may adversely affect fetal development and be excreted through the mother's milk).

Side effects Diprosalica

1. Skin irritation: Some patients may experience irritation or burning at the site of application.
2. Dry skin: The product may cause dry skin at the site of application.
3. Allergic reaction: Some people may have allergic reactions to the components of the drug, which may manifest as itching, skin rash or redness of the skin.
4. Skin breakdown: Prolonged use or application of the drug to large areas of skin may cause skin breakdown as well as possible steroid dermatitis.
5. Pigmentation disorders: In rare cases, the use of Diprosalik may cause pigmentation disorders of the skin at the site of application.
6. Skin stretching: Prolonged use of strong glucocorticosteroids such as betamethasone can lead to skin stretching.
7. Acne: Some patients may develop acne or aggravation of existing rashes due to the use of the drug.
8. Skin atrophy: Prolonged use of strong glucocorticosteroids can cause skin atrophy, especially on thin facial skin or mucous membranes.
9. Systemic side effects: If large doses or large areas of skin are used, small amounts of the active ingredient may be absorbed into the bloodstream and cause systemic side effects common to glucocorticosteroids, such as decreased immunity, hyperglycemia, osteoporosis, and others.

Overdose

1. Increased glucocorticosteroid effects: Overdose of betamethasone, which is a glucocorticosteroid, may cause an increase in its systemic side effects such as hypertension, hyperglycemia, osteoporosis, and suppression of adrenal function.
2. Increased keratolytic effects: An overdose of salicylic acid can lead to various keratolytic side effects such as skin irritation, redness, dryness, flaking, and allergic reactions.
3. Systemic side effects: In case of significant overdose of Diprosalik, the active ingredients may be absorbed into the blood in large amounts, which may lead to systemic side effects similar to those seen with systemic use of glucocorticosteroids and salicylic acid.

Interactions with other drugs

1. Other glucocorticosteroids: Co-administration of Diprosalik with other glucocorticosteroids may increase the risk of systemic side effects such as hypercorticism and decreased adrenal function.
2. Anticoagulants: Use of Diprosalik with anticoagulants, such as warfarin or heparin, may increase the risk of bleeding due to possible increased effect of salicylic acid on the GI mucosa.
3. Aspirin and other NSAIDs: The use of Diprosalik with aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of ulcers and bleeding due to the combined effect of salicylic acid and NSAIDs on the GI mucosa.
4. Insulin and hypoglycemic agents: Diprosalik use may increase hypoglycemic effects of insulin and other blood glucose-lowering agents, which requires more careful monitoring of blood glucose levels in patients with diabetes mellitus.
5. CNS-depressant drugs: The use of Diprosalik with drugs depressing the central nervous system, such as benzodiazepines or alcohol, may increase their sedative effect.

Storage conditions

The storage conditions of Diprosalik may vary depending on the specific form of release and the manufacturer of the drug. However, it is generally recommended to store Diprosalik at a temperature between 15°C and 25°C, in a dry place, protected from direct sunlight and out of reach of children.

Before you start using the drug, it is important to carefully read the instructions for use and storage, which is attached to the drug package. If the instructions indicate specific storage conditions, they should be strictly observed in order to maintain the effectiveness of the drug. If there are doubts or questions about the storage of Diprosalik, it is recommended to consult a pharmacist or your doctor.