The use of Dexdorum in combination with sedatives and hypnotics, as well as anesthetics and opioids can cause the potentiation of the effect of their effects. Due to the research, it was possible to identify the potentiation of the effect in the situation of concomitant reception with the substances sevoflurane, propofol, isoflurane, midazolam, and also alfentanil.
There were no traces of pharmacokinetic interaction between these substances (except sevoflurane) and Dexdor. But, as there is the possibility of pharmacodynamic interaction in the case of combining these drugs, the dosage of Dexdor or a sedative combined with it, anesthetic, opioid or hypnotic may require a reduction.
When combined with Dekstdorom drugs that cause a bradycardic and hypotensive effect, these effects can be intensified. But, it should be noted that in the study of the interaction of this drug with esmolol, the additional effect was moderate.